Heparan sulfate is a plasma biomarker of acute cellular allograft rejection.

Autor: Andrew S Barbas, Liwen Lin, MacKenzie McRae, Andrea L MacDonald, Tracy Truong, Yiping Yang, Todd V Brennan

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0200877 (2018)

Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection.

Externí odkaz: https://doaj.org/article/6635221561544cbdb0d5c97d3267450b

The role of human CD46 in early xenoislet engraftment in a dual transplant model

Autor: Allan D. Kirk, Robert Patrick Davis, Zachary W. Fitch, Mingqing Song, Gayathri R. Devi, Qimeng Gao, Xunrong Luo, Tam How, Kannan P. Samy, Frank V. Leopardi, Bradley H. Collins, Michael S. Mulvihill, Andrea L. MacDonald, K.D. Williams

Publikováno v: Xenotransplantation

Background Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ac33a4b628f8958165e4a63530039b
https://pubmed.ncbi.nlm.nih.gov/31219218

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation

Autor: Stephen Sacks, Miriam Manook, Anthony Dorling, Verna Curfman, Richard A. G. Smith, He Xu, Evelyn Branum, Andrea L. MacDonald, Kyle Freischlag, Kannan P. Samy, Stuart J. Knechtle, Janghoon Yoon, Michael S. Mulvihill, Alton B. Farris, David N. Howell, Jean Kwun, Christian Burghuber, Nizam Mamode

Publikováno v: Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, A L, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, A B, Smith, R A, Sacks, S, Dorling, A, Mamode, N & Knechtle, S J 2017, ' Thrombalexin: use of a cytotopic anticoagulant to reduce thrombotic microangiopathy in a highly sensitized model of kidney transplantation ', American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 17, no. 8, pp. 2055-2064 . https://doi.org/10.1111/ajt.14234

Early activation of coagulation is an important factor in the initiation of innate immunity, as characterized by thrombotic microangiopathy (TMA). In transplantation, systemic anti-coagulation is difficult due to bleeding. A novel 'cytotopic' agent,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f498418133ff3928c31eff99180fd1
https://pubmed.ncbi.nlm.nih.gov/29083552

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

Autor: Jaclyn R. Espinosa, Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, Mingqing Song, Linda L. Stempora, Jun Wang, Neal N. Iwakoshi, Allan D. Kirk

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR

Externí odkaz: https://doaj.org/article/9b50cf9d8dea4c1f9954c7be7dcd7634