Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Andrea L Hevener"'
Autor:
Sindre Lee-Ødegård, Marit Hjorth, Thomas Olsen, Gunn-Helen Moen, Emily Daubney, David M Evans, Andrea L Hevener, Aldons J Lusis, Mingqi Zhou, Marcus M Seldin, Hooman Allayee, James Hilser, Jonas Krag Viken, Hanne Gulseth, Frode Norheim, Christian A Drevon, Kåre Inge Birkeland
Publikováno v:
eLife, Vol 13 (2024)
Background: Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding of the precise molecular mechanisms underlying these effects remains incomplet
Externí odkaz:
https://doaj.org/article/d8371b2a65a34ab0b877c43460d1a3c0
Autor:
Mingqi Zhou, Ian Tamburini, Cassandra Van, Jeffrey Molendijk, Christy M Nguyen, Ivan Yao-Yi Chang, Casey Johnson, Leandro M Velez, Youngseo Cheon, Reichelle Yeo, Hosung Bae, Johnny Le, Natalie Larson, Ron Pulido, Carlos HV Nascimento-Filho, Cholsoon Jang, Ivan Marazzi, Jamie Justice, Nicholas Pannunzio, Andrea L Hevener, Lauren Sparks, Erin E Kershaw, Dequina Nicholas, Benjamin L Parker, Selma Masri, Marcus M Seldin
Publikováno v:
eLife, Vol 12 (2024)
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, and are easily assayed from blo
Externí odkaz:
https://doaj.org/article/b0b0c3945a2343e1a77c073ec88b5282
Autor:
Leandro M Velez, Cassandra Van, Timothy Moore, Zhenqi Zhou, Casey Johnson, Andrea L Hevener, Marcus M Seldin
Publikováno v:
eLife, Vol 11 (2022)
Skeletal muscle plays an integral role in coordinating physiological homeostasis, where signaling to other tissues via myokines allows for coordination of complex processes. Here, we aimed to leverage natural genetic correlation structure of gene exp
Externí odkaz:
https://doaj.org/article/dea551aef1554c2d83f6b94ccf110c2b
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10805 (2010)
Sarcopenia often co-exists with obesity, and may have additive effects on insulin resistance. Sarcopenic obese individuals could be at increased risk for type 2 diabetes. We performed a study to determine whether sarcopenia is associated with impairm
Externí odkaz:
https://doaj.org/article/0441ce51e7084b1da435e2ffd1a9cc19
Autor:
Timothy M. Moore, Lijing Cheng, Dane M. Wolf, Jennifer Ngo, Mayuko Segawa, Xiaopeng Zhu, Alexander R. Strumwasser, Yang Cao, Bethan L. Clifford, Alice Ma, Philip Scumpia, Orian S. Shirihai, Thomas Q. de Aguiar Vallim, Markku Laakso, Aldons J. Lusis, Andrea L. Hevener, Zhenqi Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Parkin plays a role in mitophagy and has been shown to control adipose tissue browning and thermogenesis. Here the authors report that Parkin coordinates mitophagy with Pgc1α-mediated mitochondrial biogenesis in white adipocytes to regulate adiposit
Externí odkaz:
https://doaj.org/article/9e68195a11cc43e7b96aa4f54f9e6c1a
Autor:
Timothy M. Moore, Sindre Lee, Thomas Olsen, Marco Morselli, Alexander R. Strumwasser, Amanda J. Lin, Zhenqi Zhou, Aaron Abrishami, Steven M. Garcia, Jennifer Bribiesca, Kevin Cory, Kate Whitney, Theodore Ho, Timothy Ho, Joseph L. Lee, Daniel H. Rucker, Christina Q.A. Nguyen, Akshay T.S. Anand, Aidan Yackly, Lorna Q. Mendoza, Brayden K. Leyva, Claudia Aliman, Daniel J. Artiga, Yonghong Meng, Sarada Charugundla, Calvin Pan, Vida Jedian, Marcus M. Seldin, In Sook Ahn, Graciel Diamante, Montgomery Blencowe, Xia Yang, Etienne Mouisel, Matteo Pellegrini, Lorraine P. Turcotte, Kåre I. Birkeland, Frode Norheim, Christian A. Drevon, Aldons J. Lusis, Andrea L. Hevener
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112499- (2023)
Summary: Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of 100 diverse strains of female mice. Candid
Externí odkaz:
https://doaj.org/article/b7fc251ad3f8402f805e30077697069d
Autor:
Frode Norheim, Thomas Bjellaas, Simon T. Hui, Karthickeyan Chella Krishnan, Jakleen Lee, Sonul Gupta, Calvin Pan, Yehudit Hasin-Brumshtein, Brian W. Parks, Daniel Y. Li, Hai H. Bui, Marian Mosier, Yuping Wu, Adriana Huertas-Vazquez, Stanley L. Hazen, Thomas E. Gundersen, Margarete Mehrabian, W.H.Wilson Tang, Andrea L. Hevener, Christian A. Drevon, Aldons J. Lusis
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1164-1174 (2018)
Elevated hepatic ceramide levels have been implicated in both insulin resistance (IR) and hepatic steatosis. To understand the factors contributing to hepatic ceramide levels in mice of both sexes, we have quantitated ceramides in a reference populat
Externí odkaz:
https://doaj.org/article/f06455053a49487895841ef47b289931
Autor:
Roberto Vicinanza, Kaname Kojima, Su-Jeong Kim, Keitaro Tanaka, Pinchas Cohen, Changhan Lee, Yasumichi Arai, Timothy M. Moore, Seiji Maeda, Yesha M. Pate, Yoichi Sutoh, Kengo Kinoshita, Yuichiro Nishida, Jialin Xiao, Brendan Miller, Hemal H. Mehta, Hisashi Naito, Noriyuki Fuku, Andrea L. Hevener, Nobuyoshi Hirose, Eri Miyamoto-Mikami, Megumi Hara, Veronica Wendy Setiawan, Hiroshi Kumagai, Kelvin Yen, Hirofumi Zempo, Junxiang Wan, Yasuki Higaki, Atsushi Shimizu
Publikováno v:
Aging (Albany NY)
Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the mtDNA polymorphisms and the therapeutic potential of mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c388113b8ccf7dca74877822c99e11
https://doi.org/10.18632/aging.202529
https://doi.org/10.18632/aging.202529
Publikováno v:
Trends in Molecular Medicine. 27:31-46
Decrements in metabolic health elevate disease risk, including type 2 diabetes, heart disease, and certain cancers. Thus, treatment strategies to combat metabolic dysfunction are needed. Reduced ESR1 (estrogen receptor, ERα) expression is observed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b8915b3b4927aea58a4eb3fa8cf267
https://doi.org/10.1016/j.molmed.2020.09.006
https://doi.org/10.1016/j.molmed.2020.09.006
