Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrea L Edwards"'
Autor:
Andrea L Edwards, Dipen P Sangurdekar, Kyeong S Jeong, Arkady B Khodursky, Valentin V Rybenkov
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84027 (2013)
MukB is a bacterial SMC (structural maintenance of chromosome) protein that regulates the global folding of the Escherichia coli chromosome by bringing distant DNA segments together. We report that moderate overproduction of MukB may lead, depending
Externí odkaz:
https://doaj.org/article/8e462ab7c13f49caad8854f0549c044b
Autor:
Monica Calero, Aina E. Cohen, Christopher O. Barnes, Irimpan I. Mathews, Guowu Lin, James F. Conway, Chaitan Khosla, Ted M. Ross, Hilary P. Stevenson, Alexander M. Makhov, Hugo Santamaria, Guillermo Calero, Andrea L. Edwards, Oliver B. Zeldin, S. Michael Soltis, Veeranagu Nagarajan
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8470-8475
The current practice for identifying crystal hits for X-ray crystallography relies on optical microscopy techniques that are limited to detecting crystals no smaller than 5 μm. Because of these limitations, nanometer-sized protein crystals cannot be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3959999aa0d1745b76498efbc2f029c1
https://doi.org/10.1073/pnas.1400240111
https://doi.org/10.1073/pnas.1400240111
Autor:
Rob Knight, Andrea L. Edwards, Francis E. Reyes, Zhenjiang Xu, Jeremiah J. Trausch, Phillip E. Ross, Robert T. Batey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 18
In bacteria, sulfur metabolism is regulated in part by seven known families of riboswitches that bind S-adenosyl-l-methionine (SAM). Direct binding of SAM to these mRNA regulatory elements governs a downstream secondary structural switch that communi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62efd4c6275fc973e886d3285ead629f
https://doi.org/10.1073/pnas.1312918111
https://doi.org/10.1073/pnas.1312918111
Publikováno v:
RNA. 16:2144-2155
S-adenosyl-(L)-homocysteine (SAH) riboswitches are regulatory elements found in bacterial mRNAs that up-regulate genes involved in the S-adenosyl-(L)-methionine (SAM) regeneration cycle. To understand the structural basis of SAH-dependent regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c03e4727116ea0456a5f28d8e6c482
https://doi.org/10.1261/rna.2341610
https://doi.org/10.1261/rna.2341610
Publikováno v:
Structure. 17:857-868
Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To understand how this high degree of specificity for closely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2d260ea565ea0aba054eb2865a0603
https://doi.org/10.1016/j.str.2009.04.009
https://doi.org/10.1016/j.str.2009.04.009
Autor:
Robert T. Batey, Andrea L. Edwards
Publikováno v:
Journal of Molecular Biology. 385:938-948
Riboswitches are noncoding RNA elements that are commonly found in the 5'-untranslated region of bacterial mRNA. Binding of a small-molecule metabolite to the riboswitch aptamer domain guides the folding of the downstream sequence into one of two mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb1f79e395da3ddad982bb15f1d505a
https://doi.org/10.1016/j.jmb.2008.10.074
https://doi.org/10.1016/j.jmb.2008.10.074
Publikováno v:
Biochemistry. 46:13297-13309
The purine riboswitch is one of a number of mRNA elements commonly found in the 5′-untranslated region capable of controlling expression in a cis-fashion via its ability to directly bind small molecule metabolites. Extensive biochemical and structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6ab30768aaed6460eae1bfb15ed621
https://doi.org/10.1021/bi700410g
https://doi.org/10.1021/bi700410g
The 6-deoxyerythronolide B synthase (DEBS) is a prototypical assembly line polyketide synthase produced by the actinomycete Saccharopolyspora erythraea that synthesizes the macrocyclic core of the antibiotic erythromycin 6-deoxyerythronolide B. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26cde5fb133eeb75394359ab0ab5aae
https://europepmc.org/articles/PMC4284093/
https://europepmc.org/articles/PMC4284093/
Publikováno v:
Methods in Molecular Biology ISBN: 9781934115893
Structural biology plays a central role in gaining a full understanding of the myriad roles of RNA in biology. In recent years, innovative approaches in RNA purification and crystallographic methods have lead to the visualization of an increasing num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1d1357e526bef0216f85e9a900b20d
https://pubmed.ncbi.nlm.nih.gov/19377976
https://pubmed.ncbi.nlm.nih.gov/19377976
Publikováno v:
Journal of bacteriology. 188(12)
MukBEF is a bacterial SMC (structural maintenance of chromosome) complex required for chromosome partitioning inEscherichia coli. We report that overproduction of MukBEF results in marked chromosome condensation. This condensation is rapid and preced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a308a2a19e51a04321fbfdf763fa2cb
https://pubmed.ncbi.nlm.nih.gov/16740950
https://pubmed.ncbi.nlm.nih.gov/16740950