Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Andrea L, Wurster"'
Autor:
Rebecca Casaday Potts, Peisu Zhang, Andrea L Wurster, Patricia Precht, Mohamed R Mughal, William H Wood, Yonqing Zhang, Kevin G Becker, Mark P Mattson, Michael J Pazin
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24515 (2011)
CHD5 is frequently deleted in neuroblastoma and is a tumor suppressor gene. However, little is known about the role of CHD5 other than it is homologous to chromatin remodeling ATPases. We found CHD5 mRNA was restricted to the brain; by contrast, most
Externí odkaz:
https://doaj.org/article/b6dc22d1f8ee429592a1873421761779
Autor:
Michael J. Pazin, Andrea L. Wurster
Publikováno v:
Biochemistry and Cell Biology. 90:1-13
One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6168275c84b16673db6eddd421fb0b
https://doi.org/10.1139/o11-042
https://doi.org/10.1139/o11-042
Publikováno v:
Molecular Immunology. 48:2178-2188
We investigated gene regulation at the IL-3/GM-CSF gene cluster. We found BRG1, a SWI/SNF remodeling ATPase, bound a distal element, CNSa. BRG1 binding was strongest in differentiated, stimulated T helper cells, paralleling IL-3 and GM-CSF expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a08b4f31f17f140790988e7369ec22e
https://doi.org/10.1016/j.molimm.2011.07.016
https://doi.org/10.1016/j.molimm.2011.07.016
Autor:
Michael J. Pazin, Patricia Precht, Supriyo De, Kevin G. Becker, William H. Wood, Andrea L. Wurster
Publikováno v:
Molecular and Cellular Biology. 31:1512-1527
T helper cell differentiation and activation require specific transcriptional programs accompanied by changes in chromatin structure. However, little is known about the chromatin remodeling enzymes responsible. We performed genome-wide analysis to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab89ab003f37b96b892fdef20b2ccb9
https://doi.org/10.1128/mcb.00920-10
https://doi.org/10.1128/mcb.00920-10
Autor:
Michael J. Grusby, Andrea L. Wurster, Tom Van Belle, Andrew P. R. Sutherland, Monia Michaud, Dorothy Zhang, Matthias von Herrath, Akira Suto
Publikováno v:
Diabetes
OBJECTIVE Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate a causal role for IL-21 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625ade805f9c1fd0208fcd65396501d9
https://doi.org/10.2337/db08-0882
https://doi.org/10.2337/db08-0882
Autor:
Andrea L. Wurster, Michael J. Pazin
Publikováno v:
Molecular and Cellular Biology. 28:7274-7285
During T helper cell differentiation, distinct programs of gene expression play a key role in defining the immune response to an environmental challenge. How chromatin remodeling events at the associated cytokine loci control differentiation is not k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdb3f637f147b05bd1c81f91b875914
https://doi.org/10.1128/mcb.00835-08
https://doi.org/10.1128/mcb.00835-08
Publikováno v:
The Journal of Immunology. 177:3721-3727
Exposure of naive Th cell precursors (Thp) to IL-21 inhibits IFN-γ production from developing Th1 cells. The inhibition of IFN-γ seen in IL-21-treated Thp cells is specific as the expression of other Th1 cytokines is unaffected. Recently, it has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786eff9cce92a3876cb0edf8a805f176
https://doi.org/10.4049/jimmunol.177.6.3721
https://doi.org/10.4049/jimmunol.177.6.3721
Autor:
Vikki L. Rodgers, Andrea L. Wurster, Michael J. Grusby, Abhay R. Satoskar, Mary Collins, Matthew J. Whitters, Deborah A. Young
Publikováno v:
The Journal of Experimental Medicine
The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b443e03575220fb74c141b4d717b91
https://doi.org/10.1084/jem.20020620
https://doi.org/10.1084/jem.20020620
Autor:
Jason M Jussif, Mayra Senices, Richard F. Konz, Marion T. Kasaian, Bijia Deng, Kaley A Johnson, Joann S. Witek, Deborah A. Young, Andrea L. Wurster, Leslie Lowe, Matthew J. Whitters, Laura L. Carter, Michael J. Grusby, Debra D. Donaldson, Mary Collins
Publikováno v:
Immunity. 16(4):559-569
IFNalpha/beta, IL-12, and IL-15 regulate NK cell activation and expansion, but signals triggering resolution of the NK response upon induction of adaptive immunity remain to be defined. We now report that IL-21, a product of activated T cells, may se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352b639c821a317287aaf3c044ae9740
Publikováno v:
Molecular and Cellular Biology. 22:117-126
Stat6 and IRS-2 are two important signaling proteins that associate with the cytoplasmic tail of the interleukin 4 (IL-4) receptor. Data from numerous in vitro experiments have led to a model for IL-4 signal transduction in which the Stat6 signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0e8ed48775499af04dcc6b23a2551a
https://doi.org/10.1128/mcb.22.1.117-126.2002
https://doi.org/10.1128/mcb.22.1.117-126.2002