Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Andrea L, Jorgensen"'
Publikováno v:
JHEP Reports, Vol 5, Iss 12, Pp 100896- (2023)
Background & Aims: Population screening for non-alcoholic fatty liver disease (NAFLD) and associated comorbidities remains an unaddressed clinical need. We aimed to assess the utility of the fatty liver index (FLI) for risk stratification of NAFLD an
Externí odkaz:
https://doaj.org/article/0858a8ffa8144ffa8d1c9923d9707b8c
Autor:
Andrea L Jorgensen, Catherine Orrell, Catriona Waitt, Cheng-Hock Toh, Christine Sekaggya-Wiltshire, Dyfrig A Hughes, Elizabeth Allen, Emmy Okello, Gayle Tatz, Giovanna Culeddu, Innocent G Asiimwe, Jerome Roy Semakula, Johannes P Mouton, Karen Cohen, Marc Blockman, Mohammed Lamorde, Munir Pirmohamed
Publikováno v:
JMIR Research Protocols, Vol 12, p e46710 (2023)
BackgroundThe quality of warfarin anticoagulation among Sub-Saharan African patients is suboptimal. This is due to several factors, including a lack of standardized dosing algorithms, difficulty in providing timely international normalized ratio (INR
Externí odkaz:
https://doaj.org/article/8aa9d5caf1144261bbc13fcb1b01ef6e
Autor:
Innocent G. Asiimwe, Marc Blockman, Karen Cohen, Clint Cupido, Claire Hutchinson, Barry Jacobson, Mohammed Lamorde, Jennie Morgan, Johannes P. Mouton, Doreen Nakagaayi, Emmy Okello, Elise Schapkaitz, Christine Sekaggya‐Wiltshire, Jerome R. Semakula, Catriona Waitt, Eunice J. Zhang, Andrea L. Jorgensen, Munir Pirmohamed
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 20-29 (2022)
Abstract Warfarin remains the most widely prescribed oral anticoagulant in sub‐Saharan Africa. However, because of its narrow therapeutic index, dosing can be challenging. We have therefore (a) evaluated and compared the performance of 21 machine
Externí odkaz:
https://doaj.org/article/a70a4a18bb0f45898c40e56846101497
Autor:
Evelien G. E. Hurkmans, Marije J. Klumpers, Cinzia Dello Russo, Ward De Witte, Henk-Jan Guchelaar, Hans Gelderblom, Anne-Marie Cleton-Jansen, Sita H. Vermeulen, Suzanne Kaal, Winette T. A. van der Graaf, Uta Flucke, Corrie E. M. Gidding, Hendrik W. B. Schreuder, Eveline S. J. M. de Bont, Huib N. Caron, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Geoff McCowage, Sumanth Nagabushan, Anuja Limaye, Victoria Rose, Daniel Catchpoole, Andrea L. Jorgensen, Christopher Barton, Lucy Delaney, Daniel B. Hawcutt, Munir Pirmohamed, Barry Pizer, Marieke J. H. Coenen, D. Maroeska W. M. te Loo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity. Therefore, a genome-wide association study w
Externí odkaz:
https://doaj.org/article/a8f79afc4fc54f8c9b487d722feb88e0
Autor:
Innocent G. Asiimwe, Marc Blockman, Karen Cohen, Clint Cupido, Claire Hutchinson, Barry Jacobson, Mohammed Lamorde, Jennie Morgan, Johannes P. Mouton, Doreen Nakagaayi, Emmy Okello, Elise Schapkaitz, Christine Sekaggya-Wiltshire, Jerome R. Semakula, Catriona Waitt, Eunice J. Zhang, Andrea L. Jorgensen, Munir Pirmohamed
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Diversity in pharmacogenomic studies is poor, especially in relation to the inclusion of black African patients. Lack of funding and difficulties in recruitment, together with the requirement for large sample sizes because of the extensive genetic di
Externí odkaz:
https://doaj.org/article/1b61f543f5f540d0bb36d6daa02e5b11
Autor:
Stephane Bourgeois, Daniel F. Carr, Crispin O. Musumba, Alexander Penrose, Celestine Esume, Andrew P. Morris, Andrea L. Jorgensen, J. Eunice Zhang, D. Mark Pritchard, Panos Deloukas, Munir Pirmohamed
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103728- (2021)
ABSTRACT: Background: Low-dose aspirin can cause gastric and duodenal ulceration, hereafter called peptic ulcer disease (PUD). Predisposition is thought to be related to clinical and genetic factors; our aim was to identify genetic risk factors assoc
Externí odkaz:
https://doaj.org/article/e356fc46996447cfa33cfd26c73f0564
Autor:
Andrea L. Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, J. Eunice Zhang, Ana Alfirevic, Munir Pirmohamed
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we showed that a dosing a
Externí odkaz:
https://doaj.org/article/c1601a65d7d1411db0d85fc7325e113a
Autor:
Marty Chaplin, Jamie J Kirkham, Kerry Dwan, Derek J Sloan, Geraint Davies, Andrea L Jorgensen
Publikováno v:
PLoS Medicine, Vol 17, Iss 9, p e1003344 (2020)
BackgroundLarge sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size an
Externí odkaz:
https://doaj.org/article/85328ad116fc4f3586fe68505e04bd82
Autor:
Marty Richardson, Jamie Kirkham, Kerry Dwan, Derek J. Sloan, Geraint Davies, Andrea L. Jorgensen
Publikováno v:
Systematic Reviews, Vol 7, Iss 1, Pp 1-15 (2018)
Abstract Background Treatment with anti-tuberculosis drugs may cause patients to experience serious adverse effects. Genetic factors, such as polymorphisms of CYP genes, may increase the likelihood of a patient experiencing such adverse drug reaction
Externí odkaz:
https://doaj.org/article/f384f6c7da7c4ed0ac743b8eddf81b6f
Autor:
Eve M. D. Smith, Peng Yin, Andrea L. Jorgensen, Michael W. Beresford, on behalf of the UK JSLE Study Group
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background Proteinuria is a well-known risk factor for progression of renal dysfunction in a variety of chronic kidney diseases. In adult-onset Systemic Lupus Erytematosus (SLE) patients with lupus nephritis (LN), proteinuria takes a signifi
Externí odkaz:
https://doaj.org/article/48fc9a6e571e4e4880c39c7bc578e107