Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrea L, Cathcart"'
Autor:
Phillip J Yates, Jennifer Moore, Jennifer Han, Andrew Skingsley, Gretja Schnell, Andrea L Cathcart, Melissa Aldinger, Amanda Peppercorn, Jill Walker
Publikováno v:
Open Forum Infectious Diseases. 9
Background Sotrovimab is a human monoclonal antibody targeting a conserved region of the SARS-CoV-2 spike (S) protein. COMET-PEAK was a 3-part, phase 2 study that evaluated intravenous (500 mg) and intramuscular (500 mg and 250 mg) administration of
Autor:
Anil K Gupta, Maria Teresa Perez-Rodríguez, Yaneicy Gonzalez-Rojas, Moti Ramgopal, Almena Free, Jennifer Han, Jennifer Moore, Rudrani Banerjee, Phillip Yates, Jill Walker, Gretja Schnell, Mary Beth Connolly, Andrea L Cathcart, Varsha Imber, Rabia Anselm, Lindsay Winograd, Nancy Haeusser, Scott Segal, Andrew Skingsley, Melissa Aldinger, Amanda Peppercorn, Jaynier Moya
Publikováno v:
Open Forum Infectious Diseases. 9
Background There is a continued need for therapeutics for the treatment of COVID-19, including intramuscular (IM) agents, which will enable broader use across a variety of healthcare delivery settings. Methods COMET-PEAK (NCT04779879) is a 3-part stu
Autor:
Maria L Agostini, Gretja Schnell, Julia di Iulio, Anita Kohli, Adrienne E Shapiro, Elias H Sarkis, Dave Inman, Amanda Peppercorn, Andrew Skingsley, Leah A Gaffney, Melissa Aldinger, Christy M Hebner, Andrea L Cathcart
Publikováno v:
Open Forum Infectious Diseases. 9
Background Sotrovimab (VIR-7831) is an engineered human monoclonal antibody targeting a conserved region of the SARS-CoV-2 spike protein; it has been shown to have a favorable safety profile and be effective for early treatment of high-risk COVID-19
Autor:
Florian A. Lempp, Tassilo Volz, Elisabetta Cameroni, Fabio Benigni, Jiayi Zhou, Laura E. Rosen, Julia Noack, Fabrizia Zatta, Hannah Kaiser, Siro Bianchi, Gloria Lombardo, Stefano Jaconi, Hasan Imam, Leah B. Soriaga, Nadia Passini, David M. Belnap, Andreas Schulze, Marc Lütgehetmann, Amalio Telenti, Andrea L. Cathcart, Gyorgy Snell, Lisa A. Purcell, Christy M. Hebner, Stephan Urban, Maura Dandri, Davide Corti, Michael A. Schmid
Background & AimsChronic hepatitis B is a major global public health problem, and coinfection with hepatitis delta virus (HDV) worsens disease outcome. Here, we describe a hepatitis B virus (HBV) surface antigen (HBsAg)-targeting monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fec46ca7004efc0b3dbdb32e584ca22
https://doi.org/10.1101/2022.09.09.507326
https://doi.org/10.1101/2022.09.09.507326
Autor:
Anil, Gupta, Yaneicy, Gonzalez-Rojas, Erick, Juarez, Manuel, Crespo Casal, Jaynier, Moya, Diego, Rodrigues Falci, Elias, Sarkis, Joel, Solis, Hanzhe, Zheng, Nicola, Scott, Andrea L, Cathcart, Sergio, Parra, Jennifer E, Sager, Daren, Austin, Amanda, Peppercorn, Elizabeth, Alexander, Wendy W, Yeh, Cynthia, Brinson, Melissa, Aldinger, Adrienne E, Shapiro, Lawrence, Sher
Publikováno v:
JAMA
IMPORTANCE: Older patients and those with comorbidities who are infected with SARS-CoV-2 may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody for the treatment of high-risk patients to prevent COVID-19 progress
Autor:
M. Cyrus Maher, Leah B. Soriaga, Anil Gupta, Julia di Iulio, Sarah Ledoux, Megan J. Smithey, Andrea L. Cathcart, Kathleen McKusick, David Sun, Melissa Aldinger, Elizabeth Alexander, Lisa Purcell, Xiao Ding, Amanda Peppercorn, Daren Austin, Erik Mogalian, Wendy W. Yeh, Adrienne E. Shapiro, Davide Corti, Herbert W. Virgin, Phillip S. Pang, Amalio Telenti
Understanding who is at risk of progression to severe COVID-19 is key to effective treatment. We studied correlates of disease severity in the COMET-ICE clinical trial that randomized 1:1 to placebo or to sotrovimab, a monoclonal antibody for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c41f803feaf8dcc79770ceca33382bb
https://doi.org/10.1101/2021.12.21.21268197
https://doi.org/10.1101/2021.12.21.21268197
Autor:
Anil Gupta, Manuel Crespo, Daren Austin, Adrienne E. Shapiro, Erick Juarez, Jennifer Sager, Joel Solis, Elizabeth Alexander, Amanda Peppercorn, Yaneicy Gonzalez-Rojas, Cynthia Brinson, Hanzhe Zheng, Nicola Scott, Elias Sarkis, Melissa Aldinger, Andrea L. Cathcart, Jaynier Moya, Diego R. Falci, Sergio Parra, Wendy W. Yeh
ImportanceOlder patients and those with underlying comorbidities infected with SARS-CoV-2 may be at increased risk of hospitalization and death from COVID-19. Sotrovimab is a neutralizing antibody designed for treatment of high-risk patients to preve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11230f5e0001f5702dcccf0ad2543a0
https://doi.org/10.1101/2021.11.03.21265533
https://doi.org/10.1101/2021.11.03.21265533
Autor:
Anil, Gupta, Yaneicy, Gonzalez-Rojas, Erick, Juarez, Manuel, Crespo Casal, Jaynier, Moya, Diego R, Falci, Elias, Sarkis, Joel, Solis, Hanzhe, Zheng, Nicola, Scott, Andrea L, Cathcart, Christy M, Hebner, Jennifer, Sager, Erik, Mogalian, Craig, Tipple, Amanda, Peppercorn, Elizabeth, Alexander, Phillip S, Pang, Almena, Free, Cynthia, Brinson, Melissa, Aldinger, Adrienne E, Shapiro, Luis, Zepeda
Publikováno v:
The New England journal of medicine. 385(21)
Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to prevent progression of Covid-
Autor:
Louis M. Schwartzman, Andrea L. Cathcart, Lindsey M. Pujanauski, Li Qi, John C. Kash, Jeffery K. Taubenberger
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics. The current strategy for preventing annual influenza is to develop a new vaccine ea
Externí odkaz:
https://doaj.org/article/cea1cc51d5b54d1b8b118a8c21c76d8d
Autor:
M. Cyrus Maher, Leah B. Soriaga, Anil Gupta, Yi-Pei Chen, Julia di Iulio, Sarah Ledoux, Megan J. Smithey, Andrea L. Cathcart, Kathleen McKusick, David Sun, Melissa Aldinger, Elizabeth Alexander, Lisa Purcell, Xiao Ding, Amanda Peppercorn, Daren Austin, Erik Mogalian, Wendy W. Yeh, Adrienne E. Shapiro, Davide Corti, Herbert W. Virgin, Phillip S. Pang, Amalio Telenti
Publikováno v:
Cell Reports Medicine. 3:100721
Understanding who is at risk of progression to severe coronavirus disease 2019 (COVID-19) is key to clinical decision making and effective treatment. We study correlates of disease severity in the COMET-ICE clinical trial that randomized 1:1 to place