Výsledky vyhledávání - "Andrea Koppius"

Endogenous Transforming Growth Factor β1 Suppresses Inflammation and Promotes Survival in Adult CNS

Autor: Mariya Hristova, Marion Bohatschek, Andrea Koppius, Thomas Doetschman, Ilona Ormsby, Karl Bauer, Milan Makwana, Dietmute Bueringer, Gennadij Raivich, Heike Heuer, Leonard L. Jones, Dan Cuthill, Sönke Friedrichsen

Publikováno v: The Journal of Neuroscience. 27:11201-11213

Transforming growth factor beta1 (TGFbeta1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system. In the current study, we examined the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5181bfbb84ce0dee33591862998c7939
https://doi.org/10.1523/jneurosci.2255-07.2007

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Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice

Autor: Roger Kalla, Andrea Koppius, Alexander Werner, ZhiQiang Liu, Leonard L. Jones, ShengLi Xu, Christian U.A. Kloss, Andreas Gschwendtner, Marion Bohatschek, Matthias Galiano, Horst Bluethmann, Gennadij Raivich

Publikováno v: European Journal of Neuroscience. 14:327-341

Nerve injury triggers numerous changes in the injured neurons and surrounding non-neuronal cells. Of particular interest are molecular signals that play a role in the overall orchestration of this multifaceted cellular response. Here we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab3bfdefbd64c26e19b157e7fe967d28
https://doi.org/10.1046/j.0953-816x.2001.01647.x

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Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-defici

Autor: ZhiQiang Liu, Cua Kloss, SL Xu, Andreas Gschwendtner, Andrea Koppius, Alexander Werner, Y Imai, S Kohsaka, JC Moller, Gennadij Raivich, Roger Kalla

Publikováno v: Journal of Comparative Neurology. 436:182-201

Activation of microglia is among the first cellular changes in the injured CNS. However, little is known about their specific contribution to secondary damage or repair processes in neighboring neurons and nonneuronal cells or to the immune surveilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05916c74aed8757d2254c87fb29ebd1e
https://doi.org/10.1002/cne.1060

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Use of an exon-trapping vector for the evaluation of splice-site mutations

Autor: Reinhard Sedlmeier, Andrea Koppius, Boris Schneider

Publikováno v: Mammalian genome : official journal of the International Mammalian Genome Society. 18(9)

Prediction of the effects of splice-site variations by sequence analysis is difficult. In this study we provide the means for a rapid evaluation of the potential for splice-site mutations to interfere with RNA processing. The system may be useful in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c122eac8d36809dc33998aead7a32f
https://pubmed.ncbi.nlm.nih.gov/17687606

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