Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Andrea K. Houghton"'
Autor:
Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 230-243 (2022)
As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to rodents pro
Externí odkaz:
https://doaj.org/article/55057518620746559c951066d12dfcf1
Autor:
Jeanine E. Ballard, Parul S. Pall, Joshua Vardigan, Fuqiang Zhao, Marie A. Holahan, Xiaoping Zhou, Nina Jochnowitz, Richard L. Kraus, Rebecca M. Klein, Darrell A. Henze, Andrea K. Houghton, Christopher S. Burgey, Christopher Gibson, Arie Struyk
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
MK-2075 is a small-molecule selective inhibitor of the NaV1.7 channel investigated for the treatment of postoperative pain. A translational strategy was developed for MK-2075 to quantitatively interrelate drug exposure, target modulation, and the des
Externí odkaz:
https://doaj.org/article/b6acf3025c844a49ac376ac7097521ef
Autor:
Fuqiang Zhao, Xiangjun Meng, Sherry Lu, Lynn A. Hyde, Matthew E. Kennedy, Andrea K. Houghton, Jeffrey L. Evelhoch, Catherine D.G. Hines
Publikováno v:
NeuroImage, Vol 213, Iss , Pp 116725- (2020)
Functional magnetic resonance imaging (fMRI) is a valuable tool for studying neural activations in the central nervous system of animals due to its wide spatial coverage and non-invasive nature. However, the advantages of fMRI have not been fully rea
Externí odkaz:
https://doaj.org/article/23615477c4224772ac051ceaf925b948
Autor:
Christopher Daley, Yuxing Li, Haiyan Sun, Xiu Wang, Fuqiang Zhao, Michelle K. Clements, Rebecca M. Klein, Aneta Jovanovska, Andrew Brunskill, Joseph E. Pero, Xuanjia Peng, Thomas J. Greshock, Christopher S. Burgey, Mark E. Layton, Jeanine E. Ballard, Deping Wang, Richard L. Kraus, Andrea K. Houghton, Anthony J. Roecker, Michael J. Kelly
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1038-1049
The voltage-gated sodium channel Nav1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and advanced into the clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5074c01bd9b85bda35e405231de481ea
https://doi.org/10.1021/acsmedchemlett.1c00218
https://doi.org/10.1021/acsmedchemlett.1c00218
Autor:
Bao Jen Shyong, David G. McLaren, Maria Webb, Joel Mane, Stephen F. Previs, Haihong Zhou, David E. Kelley, Carlos G. Rodriguez, Kevin P. Bateman, Yichen Wang, Daniel P. Downes, Natalie A. Daurio, George H. Addona, Andrea K. Houghton, Ying Chen, Peter Zafian, Ester Carballo-Jane, Rena Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E1105-E1117
The regulation of nutrient homeostasis, i.e., the ability to transition between fasted and fed states, is fundamental in maintaining health. Since food is typically consumed over limited (anabolic) periods, dietary components must be processed and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859551c265999db7b7b6deaead504442
https://doi.org/10.1152/ajpendo.00459.2018
https://doi.org/10.1152/ajpendo.00459.2018
Autor:
Richard L. Kraus, Ronald M. Kim, Jeanine E. Ballard, Thomas J. Greshock, Andrea K. Houghton, Michelle K. Clements, Marie A. Holahan, Andrew Danziger, Christopher S. Burgey, Yuxing Li, Mark E. Layton, Jordi Serra, Parul S. Pall, Rebecca M. Klein, Joshua D. Vardigan, Dan Zhou, Fuqiang Zhao, Christopher Daley, Darrell A. Henze
Publikováno v:
Science Translational Medicine. 13
Humans with loss-of-function mutations in the Nav1.7 channel gene (SCN9A) show profound insensitivity to pain, whereas those with gain-of-function mutations can have inherited pain syndromes. Therefore, inhibition of the Nav1.7 channel with a small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2568b727c558da3b3a2a03b719a658df
https://doi.org/10.1126/scitranslmed.aay1050
https://doi.org/10.1126/scitranslmed.aay1050
Autor:
Anthony J, Roecker, Mark E, Layton, Joseph E, Pero, Michael J, Kelly, Thomas J, Greshock, Richard L, Kraus, Yuxing, Li, Rebecca, Klein, Michelle, Clements, Christopher, Daley, Aneta, Jovanovska, Jeanine E, Ballard, Deping, Wang, Fuqiang, Zhao, Andrew P J, Brunskill, Xuanjia, Peng, Xiu, Wang, Haiyan, Sun, Andrea K, Houghton, Christopher S, Burgey
Publikováno v:
ACS Med Chem Lett
[Image: see text] The voltage-gated sodium channel Na(v)1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72b379a09d4cd36535ea9e98211ef1a7
https://pubmed.ncbi.nlm.nih.gov/34141090
https://pubmed.ncbi.nlm.nih.gov/34141090
Autor:
Joshua D. Vardigan, Christopher R. Gibson, Darrell A. Henze, Andrea K. Houghton, Marie A. Holahan, Fuqiang Zhao, Parul S. Pall, Richard L. Kraus, Yuxing Li, Jeanine E. Ballard, Christopher S. Burgey
Publikováno v:
Pharmaceutical Research
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d130ec34ee918806de2014440a8f808
http://europepmc.org/articles/PMC7473964
http://europepmc.org/articles/PMC7473964
Autor:
Andrea K. Houghton, Aneta Jovanovska, Tracey Filzen, Ying-Hong Wang, Jacqueline Panigel, Annie Liang, Michelle K. Clements, Rebecca M. Klein, Richard L. Kraus, John Majercak, Eleftheria N. Finger, Jixin Wang, Matthew J. Cato, Hannah D. G. F. Lehman, Christopher Daley, Yun Gregan, James Mulhearn, Yuxing Li, Michael A. Rossi, Darrell A. Henze, Mark O. Urban, Michael J. Kelly, Scott E. Wolkenberg, Mark E. Layton, Joseph E. Pero
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2683-2688
Studies on human genetics have suggested that inhibitors of the Nav1.7 voltage-gated sodium channel hold considerable promise as therapies for the treatment of chronic pain syndromes. Herein, we report novel, peripherally-restricted benzoxazolinone a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa8cc863252cd7ed266d6ff8eb35f8f
https://doi.org/10.1016/j.bmcl.2017.04.040
https://doi.org/10.1016/j.bmcl.2017.04.040
Autor:
Mark E. Layton, Eleftheria N. Finger, Edward C. Sherer, Amy Jo Koser, Aneta Jovanovska, Robert Gomez, Xiu Wang, Deping Wang, Xuanjia Peng, John Majercak, Melissa Egbertson, Paul J. Coleman, Rebecca M. Klein, Kristen L.G. Jones, Richard L. Kraus, Jixin Wang, Tracey Filzen, Mark O. Urban, Yuxing Li, Anthony J. Roecker, Matthew J. Cato, Ying-Hong Wang, Michelle K. Clements, Jacqueline Panigel, Leo A. Joyce, Vincent P. Santarelli, Irene Gregan, Christopher Daley, Haiyan Sun, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2087-2093
The voltage-gated sodium channel Nav1.7 is a genetically validated target for the treatment of pain with gain-of-function mutations in man eliciting a variety of painful disorders and loss-of-function mutations affording insensitivity to pain. Unfort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6460ec06d229cf43b30709ab80de83e3
https://doi.org/10.1016/j.bmcl.2017.03.085
https://doi.org/10.1016/j.bmcl.2017.03.085