Výsledky vyhledávání - "Andrea K Brown"

Akademický článek

Treatment With Lisinopril Prevents the Early Progression of Glomerular Injury in Obese Dahl Salt-Sensitive Rats Independent of Lowering Arterial Pressure

Autor: Andrea K. Brown, Alyssa Nichols, Chantell A. Coley, Ubong S. Ekperikpe, Kasi C. McPherson, Corbin A. Shields, Bibek Poudel, Denise C. Cornelius, Jan M. Williams

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Recently, we reported that obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats develop glomerular injury and progressive proteinuria prior to puberty. Moreover, this early progression of proteinuria was associated with elevations in

Externí odkaz: https://doaj.org/article/c06185c5325645038e7355fb108bec35

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Akademický článek

Treatment With Gemfibrozil Prevents the Progression of Chronic Kidney Disease in Obese Dahl Salt-Sensitive Rats

Autor: Corbin A. Shields, Bibek Poudel, Kasi C. McPherson, Andrea K. Brown, Ubong S. Ekperikpe, Evan Browning, Lamari Sutton, Denise C. Cornelius, Jan M. Williams

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Recently, we reported that Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats exhibit dyslipidemia and renal lipid accumulation independent of hyperglycemia that progresses to chronic kidney disease (CKD). Therefore, in the current study,

Externí odkaz: https://doaj.org/article/7777d20ca2ed44659435d418f972fdad

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Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats

Autor: Jan M. Williams, Andrea K Brown, Geilda A. Tardo, Tyler Johnson, Chelsea Giachelli, Denise C. Cornelius, Madison T. Crosby, Olivia K. Travis, Shani Siddiq, Henry T. Nguyen

Publikováno v: Pregnancy Hypertens

We recently reported that adoptive transfer of cytolytic Natural Killer cells (cNKs) from the Reduced Uterine Perfusion Pressure (RUPP) rat induces a preeclampsia (PE)-like phenotype in pregnant rats, accompanied by increased TNF-α. The purpose of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5763565112865afbdba057cb414e4e9
https://doi.org/10.1016/j.preghy.2021.05.002

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Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats

Autor: Jan M. Williams, Corbin A. Shields, Ubong Ekperikpe, Bibek Poudel, Denise C. Cornelius, Tyler Johnson, Andrea K Brown

Publikováno v: Am J Physiol Renal Physiol

Recently, we reported that obese Dahl salt-sensitive (SS) leptin receptor mutant (SSLepRmutant) rats display progressive renal injury. The present study demonstrated that the early development of renal injury in the SSLepRmutant strain is associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dacefe4a8e3101665a78a1e17702e73
https://doi.org/10.1152/ajprenal.00100.2020

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The SS(LepR) mutant rat represents a novel model to study obesity-induced renal injury before puberty

Autor: Bibek Poudel, Corbin A. Shields, Ubong S. Ekperikpe, Andrea K. Brown, Olivia K. Travis, Jordan C. Maury, Sarah Fitzgerald, Stanley V. Smith, Denise C. Cornelius, Jan M. Williams

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Prepubertal obesity (PPO) has emerged as a major health problem over the past few decades and is a risk factor for the development of proteinuria. The current study investigated whether the development of renal injury in the obese SSLepR mutant strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4948626b212414c1e17edac972a7f
https://europepmc.org/articles/PMC8917907/

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Abstract 42: Inhibiting Stimulatory Dendritic Cells Reduces Early Progressive Proteinuria In Obese Dahl Salt-sensitive Rats

Autor: Andrea K Brown, Denise C. Cornelius, Ubong Ekperikpe, Corbin A. Shields, Bibek Poudel, Jan M. Williams

Publikováno v: Hypertension. 78

Childhood/prepubertal (PPO) obesity has emerged as an epidemic and major health problem over the last few decades and is a risk factor for the development of proteinuria. With the rising prevalence of obesity in children, studies examining how obesit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b367bfde5a6d0d2b398b263b192d6f8b
https://doi.org/10.1161/hyp.78.suppl_1.42

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Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats

Autor: Madison T. Crosby, Olivia K. Travis, Jan M. Williams, Alex N Smith, Henry T. Nguyen, Geilda A. Tardo, Denise C. Cornelius, Tyler Johnson, George W. Booz, Chelsea Giachelli, Andrea K Brown, Shani Siddiq

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Preeclampsia (PE) is characterized by maternal hypertension, intrauterine growth restriction, and increased cytolytic natural killer cells (cNKs), which secrete interferon γ (IFNγ). However, the precise role of IFNγ in contributing to PE pathophys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a099a63bf43792b3dc43129f6e7a5d55
https://europepmc.org/articles/PMC8409917/

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