Výsledky vyhledávání - "Andrea Jantsch"

Akademický článek

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

Autor: Andrea Jantsch, Lidia Nieto, Jürg Gertsch, Javier Rodríguez-Salarichs, Ruth Matesanz, Jesús Jiménez-Barbero, J. Fernando Díaz, Ángeles Canales, Karl-Heinz Altmann

Publikováno v: Molecules, Vol 21, Iss 8, p 1010 (2016)

12-Aza-epothilones (azathilones) incorporating quinoline side chains and bearing different N12-substituents have been synthesized via highly efficient RCM-based macrocyclizations. Quinoline-based azathilones with the side chain N-atom in the meta-pos

Externí odkaz: https://doaj.org/article/ccbbdb16c1a049729b87298363d0867f

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Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

Autor: Jürg Gertsch, Jesús Jiménez-Barbero, Andrea Jantsch, J. Fernando Díaz, Ángeles Canales, Lidia Nieto, Ruth Matesanz, Karl-Heinz Altmann, Javier Rodríguez-Salarichs

Publikováno v: Jantsch, Andrea; Nieto, Lidia; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth; Jiménez-Barbero, Jesús; Díaz, J Fernando; Canales, Ángeles; Altmann, Karl-Heinz (2016). Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones). Molecules, 21(8) Molecular Diversity Preservation International MDPI 10.3390/molecules21081010
Digital.CSIC. Repositorio Institucional del CSIC
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Molecules
Molecules, Vol 21, Iss 8, p 1010 (2016)
Molecules; Volume 21; Issue 8; Pages: 1010
Molecules, 21 (8)

26 p.-6 fig.2 tab.
12-Aza-epothilones (azathilones) incorporating quinoline side chains and bearing different N12-substituents have been synthesized via highly efficient RCM-based macrocyclizations.Quinoline-based azathilones with the side chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae29bae214bed3de32f33c0690a720d

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Synthesis of 12-aza analogs of epothilones and (E)-9,10-dehydroepothilones

Autor: Bernhard Pfeiffer, Fabian Feyen, Kurt Hauenstein, Andrea Jantsch, Karl-Heinz Altmann

Publikováno v: Tetrahedron. 64:7920-7928

N-Boc-12-aza-epothilone analog (azathilone) 1 is a potent inhibitor of human cancer cell growth and represents a structurally new class of natural product-derived microtubule-stabilizing agents. Compound 1 has been prepared employing a convergent str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b73111d31f77cfaa42724becc727e54
https://doi.org/10.1016/j.tet.2008.06.017

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Synthetic Studies on Mycolactones: Synthesis of the Mycolactone Core Structure through Ring-Closing Olefin Metathesis

Autor: Fabian Feyen, Karl-Heinz Altmann, Andrea Jantsch

Publikováno v: Synlett. 2007:0415-0418

The mycolactone core structure 2a has been prepared through ring-closing olefin metathesis from diene 3 with exquisite E selectivity. The preparation of diene 3 included a highly efficient stereoselective synthesis of carboxylic acid 5. The mycolacto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::091de1d9a5a8651875a84a6d4f8a5f4e
https://doi.org/10.1055/s-2007-967943

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Diastereoselective Titanium Enolate Aldol Reaction for the Total Synthesis of Epothilones

Autor: Olivier Loiseleur, and Andrea Jantsch, Guido Koch, Daniel Fuentes, Karl-Heinz Altmann

Publikováno v: Organic Letters. 4:3811-3814

[formula: see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13995cfbd95515c29f292b06327894f
https://doi.org/10.1021/ol026480b

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A ring-closing metathesis (RCM)-based approach to mycolactones A/B

Autor: Jean-Pierre Dangy, Andrea Jantsch, Karl-Heinz Altmann, Fabian Feyen, Nicole Scherr, Gerd Pluschke, Philipp Gersbach

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 17(46)

The total synthesis of the mycobacterial toxins mycolactones A/B (1 a/b) has been accomplished based on a strategy built around the construction of the mycolactone core through ring-closing metathesis. By employing the Grubbs second-generation cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b9db6dc9ea668dea6bffd0c5844c0c
https://pubmed.ncbi.nlm.nih.gov/21971832

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