Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andrea J. Kriz"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest
Externí odkaz:
https://doaj.org/article/f77d839a60d344f6adff030162be5749
Autor:
Brian C Del Rosario, Andrea J Kriz, Amanda M Del Rosario, Anthony Anselmo, Christopher J Fry, Forest M White, Ruslan I Sadreyev, Jeannie T Lee
Publikováno v:
eLife, Vol 8 (2019)
The zinc finger CCCTC-binding protein (CTCF) carries out many functions in the cell. Although previous studies sought to explain CTCF multivalency based on sequence composition of binding sites, few examined how CTCF post-translational modification (
Externí odkaz:
https://doaj.org/article/2fb595442f4c4601ab5d0c6c0fd0d757
Autor:
Yong-Woo Lee, Brian C. Del Rosario, Hyun Jung Oh, Andrea J. Kriz, Myriam Boukhali, Wilhelm Haas, Jeannie T. Lee, Hun-Goo Lee, Eric Aeby
Publikováno v:
Nature Cell Biology. 22:1116-1129
How allelic asymmetry is generated remains a major unsolved problem in epigenetics. Here we model the problem using X-chromosome inactivation by developing "BioRBP", an enzymatic RNA-proteomic method that enables probing of low-abundance interactions
Autor:
Jeannie T. Lee, Kevin M. Tan, Anna Lappala, Karissa Y. Sanbonmatsu, Chen-Yu Wang, Andrea J. Kriz, Hunter Michalk
Publikováno v:
Proc Natl Acad Sci U S A
Chromosomes are segmented into domains and compartments, but how these structures are spatially related in three dimensions (3D) is unclear. Here, we developed tools that directly extract 3D information from Hi-C experiments and integrate the data ac
Autor:
Barry Kesner, Hyun Jung Oh, Rodrigo Aguilar, Andrea J. Kriz, Hsueh-Ping Chu, Jeannie T. Lee, Hun-Goo Lee
Publikováno v:
Cell. 184(25)
Summary Chromosome loops shift dynamically during development, homeostasis, and disease. CCCTC-binding factor (CTCF) is known to anchor loops and construct 3D genomes, but how anchor sites are selected is not yet understood. Here, we unveil Jpx RNA a
Publikováno v:
Mol Cell
Depletion of architectural factors globally alters chromatin structure but only modestly affects gene expression. We revisit the structure-function relationship using the inactive X chromosome (Xi) as a model. We investigate cohesin imbalances by for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3169792a46945da47096df24be2f6e
https://europepmc.org/articles/PMC8106664/
https://europepmc.org/articles/PMC8106664/
Autor:
Jeannie T. Lee, Anna Lappala, Karissa Y. Sanbonmatsu, Kevin M. Tan, Chaolong Wang, Andrea J. Kriz, Michalk H
Chromosomes are segmented into domains and compartments; yet, how these structures are spatially related in 3D is unclear. Here, by directly integrating Hi-C capture experiments and 3D modeling, we use X-inactivation as a model to examine the time ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e3a3ad0fdfa9adc1284a6b6d52c875
https://doi.org/10.1101/2021.01.21.427652
https://doi.org/10.1101/2021.01.21.427652
SUMMARYDepletion of architectural factors globally alters chromatin structure, but only modestly affects gene expression. We revisit the structure-function relationship using the inactive X chromosome (Xi) as a model. We investigate cohesin imbalance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c60a4b9798803f2f1f9ca3f4ceaf648e
https://doi.org/10.1101/2021.01.13.426565
https://doi.org/10.1101/2021.01.13.426565
Summary During X-inactivation, Xist RNA spreads along an entire chromosome to establish silencing. However, the mechanism and functional RNA elements involved in spreading remain undefined. By performing a comprehensive endogenous Xist deletion scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2749d980f7715812c6e4b6c3508243
https://europepmc.org/articles/PMC6469964/
https://europepmc.org/articles/PMC6469964/