Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo.

Autor: Tyler D Bold, Niaz Banaei, Andrea J Wolf, Joel D Ernst

Publikováno v: PLoS Pathogens, Vol 7, Iss 5, p e1002063 (2011)

Adaptive immunity to Mycobacterium tuberculosis controls progressive bacterial growth and disease but does not eradicate infection. Among CD4+ T cells in the lungs of M. tuberculosis-infected mice, we observed that few produced IFN-γ without ex vivo

Externí odkaz: https://doaj.org/article/8140d056326841c899773fd59d336eb4

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

Autor: Neha Mishra, Magdalena Westermann, Nina Sommer, Philip Rosenstiel, Fredrik Bäckhed, Dora Bordoni, Marijana Basic, Christoph Kaleta, Johannes Zimmermann, Lena Schröder, Felix Sommer, Kenneth Klischies, Stefan Krautwald, Georgios Marinos, Simon Imm, Ruth A. Schmitz, Bärbel Stecher, Kensuke Shima, Jan Rupp, Jacob Hamm, Valentina Tremaroli, Finn Hinrichsen, Robert Häsler, Philippe Schmitt-Kopplin, Alesia Walker, Andrea J. Wolf, Antonella Fazio, Daniela Prasse, Sina Kaiser, Georg Laue

Publikováno v: Cell Metab. 33, 2355-2366.e8 (2021)
Hinrichsen, F, Hamm, J, Westermann, M, Schröder, L, Shima, K, Mishra, N, Walker, A, Sommer, N, Klischies, K, Prasse, D, Zimmermann, J, Kaiser, S, Bordoni, D, Fazio, A, Marinos, G, Laue, G, Imm, S, Tremaroli, V, Basic, M, Häsler, R, Schmitz, R A, Krautwald, S, Wolf, A, Stecher, B, Schmitt-Kopplin, P, Kaleta, C, Rupp, J, Bäckhed, F, Rosenstiel, P & Sommer, F 2021, ' Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis ', Cell Metabolism, vol. 33, no. 12, pp. 2355-2366.e8 . https://doi.org/10.1016/j.cmet.2021.11.004

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ff874f57137415da69016c677d9213
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63735

Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes

Autor: Anthony M Castro, Andrea J. Wolf, Alexander D. Prince, David M. Underhill, Jose J. Limon, Christopher Nguyen

Publikováno v: J Leukoc Biol

Malassezia spp. are common eukaryotic yeasts that colonize mammalian skin. Recently, the authors and others have observed that Malassezia globosa and Malassezia restricta can be found in the intestines in the context of certain diseases, including Cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2920ce06673285c7812482078dc8e533
https://europepmc.org/articles/PMC7902306/

Inflammatory properties of antibiotic-treated bacteria

Autor: Andrea J. Wolf, David M. Underhill, George Y. Liu

Publikováno v: Journal of Leukocyte Biology. 101:127-134

Antibiotics have proven to be enormously effective tools in combating infectious diseases. A common roadblock to the effective use of antibiotics is the development of antibiotic resistance. We have recently observed that the very mechanism by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b63cb01200db5f0f9807fc30f25a4
https://doi.org/10.1189/jlb.4mr0316-153rr

Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology

Autor: George Y. Liu, Bethany L. Berg, Iliyan D. Iliev, Sabrina Müller, Andrea J. Wolf, David M. Underhill

Publikováno v: Cell Host & Microbe. 18(5):604-612

SummaryMethicillin-resistant S. aureus (MRSA) is a leading health problem. Compared to methicillin-sensitive S. aureus, MRSA infections are associated with greater morbidity and mortality, but the mechanisms underlying MRSA pathogenicity are unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff78232eb672d265324801e97faf3b1f