Výsledky vyhledávání - "Andrea J Parsons"

Akademický článek

Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory.

Autor: Jardin A Leleux, Tina C Albershardt, Rebecca Reeves, Reice James, Jordan Krull, Andrea J Parsons, Jan Ter Meulen, Peter Berglund

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0259301 (2021)

Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two IL12-expressing vector platforms, both of which can overcome the deficiencies of previous system

Externí odkaz: https://doaj.org/article/b0930d7daf3d499b8f67741020c6c439

Zobrazit plný text záznamu

Akademický článek

Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice

Autor: Carly M. Bliss, Andrea J. Parsons, Raffael Nachbagauer, Jennifer R. Hamilton, Federica Cappuccini, Marta Ulaszewska, Jason P. Webber, Aled Clayton, Adrian V.S. Hill, Lynda Coughlan

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 108-125 (2020)

Adenoviral (Ad) vectors represent promising vaccine platforms for infectious disease. To overcome pre-existing immunity to commonly used human adenovirus serotype 5 (Ad5), vectors based on rare species or non-human Ads are being developed. However, t

Externí odkaz: https://doaj.org/article/cd6a0c58b0e84b3aad7a70894ddac5d1

Zobrazit plný text záznamu

ZVex™, a dendritic-cell-tropic lentivector, primes protective antitumor T cell responses that are significantly boosted using heterologous vaccine modalities

Autor: Tina C. Albershardt, Peter Berglund, Jardin A. Leleux, Jan ter Meulen, Andrea J. Parsons

Publikováno v: Vaccine. 38:6367-6373

Therapeutic cancer vaccines must induce high levels of tumor-specific cytotoxic CD8 T cells to be effective. We show here that tumor-antigen specific effector and memory T cell responses primed with a non-integrating, dendritic-cell targeted lentivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be61b49ced074faa5c631e2fe648059
https://doi.org/10.1016/j.vaccine.2020.08.003

Zobrazit plný text záznamu

Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine

Autor: Tina C. Albershardt, Rebecca S. Reeves, Peter Berglund, Patrick A. Flynn, David J. Campbell, Andrea J. Parsons, Jan ter Meulen

Publikováno v: Vaccine. 38:3369-3377

While immune checkpoint inhibition is rapidly becoming standard of care in many solid tumors, immune checkpoint inhibitors (ICIs) fail to induce clinical responses in many patients, presumably due to insufficient numbers of tumor-specific T cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ea6db65f5197aeccfd9f1924f252ab
https://doi.org/10.1016/j.vaccine.2020.02.034

Zobrazit plný text záznamu

Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus

Autor: Andrea J. Parsons, Sabrina I. Ophir, Thomas J. Gardner, Jailene Casado Paredes, Kathryn R. Stein, Steven M. Kwasny, Steven C. Cardinale, Matthew Torhan, Mark N. Prichard, Scott H. James, Kristina E. Atanasoff, Narendran G-Dayanandan, Terry L. Bowlin, Timothy J. Opperman, Domenico Tortorella

Publikováno v: Antiviral Research. 209:105474

Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and mortality. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc4316f8c6a98fd65200109a1564e
https://doi.org/10.1016/j.antiviral.2022.105474

Zobrazit plný text záznamu

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Autor: Andrea J. Parsons, Sabrina I. Ophir, J. Andrew Duty, Thomas A. Kraus, Kathryn R. Stein, Thomas M. Moran, Domenico Tortorella

Publikováno v: Communications biology. 5(1)

Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant recipients and newborns. New anti-HCMV therapies are an urgent medical need for diverse patient populations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39327ff8c407bca4f74d6cad8a50f6f4
https://pubmed.ncbi.nlm.nih.gov/35468974

Zobrazit plný text záznamu

Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Autor: Peter Berglund, Jardin A. Leleux, Jordan E. Krull, Reice James, Tina C. Albershardt, Rebecca S. Reeves, Jan ter Meulen, Andrea J. Parsons

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0259301 (2021)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3be3a76b971d7f938035ccece3a3c1
https://doaj.org/article/b0930d7daf3d499b8f67741020c6c439

Zobrazit plný text záznamu

Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors

Autor: Peter Berglund, Jardin A. Leleux, Andrea J. Parsons, Jordan E. Krull, Tina C. Albershardt, Jan ter Meulen

Publikováno v: npj Vaccines, Vol 5, Iss 1, Pp 1-9 (2020)
NPJ Vaccines

Effective T cell-based immunotherapy of solid malignancies requires intratumoral activity of cytotoxic T cells and induction of protective immune memory. A major obstacle to intratumoral trafficking and activation of vaccine-primed or adoptively tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab375c60247fdea37794862382d2395
https://doi.org/10.1038/s41541-020-0201-x

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání