Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andrea J A, Schauenburg"'
Autor:
David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre J. Rizkallah, Andrew K. Sewell
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Serial accumulation of mutations to fixation in the SLYNTVATL (SL9) immunodominant, HIV p17 Gag-derived, HLA A2-restricted cytotoxic T lymphocyte epitope produce the SLFNTIAVL triple mutant “ultimate” escape variant. These mutations in solvent-ex
Externí odkaz:
https://doaj.org/article/2e44b85e69cd4584a5aba4121bc60462
Autor:
Robert Andrews, Sarah Nicol Lauder, Aaron Wall, Kathryn Smart, Bruce J. MacLachlan, Meriem Attaf, Pierre J. Rizkallah, Dhanasekaran Vijaykrishna, Yuan Chen, Georgina H. Mason, Andrew James Godkin, Garry Dolton, Mikhail Shugay, David K. Cole, Angharad Lloyd, Cristina Rius, Andrew K. Sewell, Miguel L. Grau, Andrea J. A. Schauenburg, Alexander Greenshields-Watson, Hywel Hughes, Kathryn E. Strange, Awen Gallimore, James Geary, Sarah Hulin-Curtis, Thomas Whalley
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885-(2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75db8e6035331d3fe6e4c0c6bffbf5e9
Autor:
John J Miles, Anna M Bulek, David K Cole, Emma Gostick, Andrea J A Schauenburg, Garry Dolton, Vanessa Venturi, Miles P Davenport, Mai Ping Tan, Scott R Burrows, Linda Wooldridge, David A Price, Pierre J Rizkallah, Andrew K Sewell
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001198 (2010)
Despite the ∼10(18) αβ T cell receptor (TCR) structures that can be randomly manufactured by the human thymus, some surface more frequently than others. The pinnacles of this distortion are public TCRs, which exhibit amino acid-identical structur
Externí odkaz:
https://doaj.org/article/306c4ef650b24c9d8ee4fe6f2fc17f93
Autor:
Andrea J. A. Schauenburg, Matthieu Besneux, Bruce J. MacLachlan, David K. Cole, Barbara Szomolay, Tim Elliott, Awen Gallimore, Garry Dolton, Andrew K. Sewell, Alexander Greenshields-Watson, Athanasios Papakyriakou, Pierre J. Rizkallah, Andrew James Godkin, Georgina H. Mason
Publikováno v:
The Journal of Biological Chemistry
CD4+ T-cells recognize peptide antigens, in the context of human leukocyte antigen (HLA) class II molecules (HLA-II), which through peptide-flanking residues (PFRs) can extend beyond the limits of the HLA binding. The role of the PFRs during antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c61cec5cc9e6c62a6e657e5257cb79
https://eprints.soton.ac.uk/443721/
https://eprints.soton.ac.uk/443721/
Autor:
Andrew James Godkin, Florian Madura, Andrew K. Sewell, David K. Cole, Jade R. Hopkins, Nathaniel Liddy, Anna Marta Bulek, Andrew Trimby, E. Joel Loveridge, Andrea J. A. Schauenburg, Pierre J. Rizkallah, Bent K. Jakobsen, Stephen A. Wells, Anna Fuller, John J. Miles, Mateusz Legut, Malkit Sami, Christopher J. Holland, Yi Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05af3d7484dbdca54fcaedb0db319f63
https://doi.org/10.1002/eji.201948085/v2/response1
https://doi.org/10.1002/eji.201948085/v2/response1
Autor:
Florian Madura, Anna Fuller, Christopher J. Holland, David K. Cole, Pierre J. Rizkallah, Andrew James Godkin, Andrew K. Sewell, Andrea J. A. Schauenburg, Anna Marta Bulek
Publikováno v:
European Journal of Immunology. 45:584-591
MHC anchor residue-modified “heteroclitic” peptides have been used in many cancer vaccine trials and often induce greater immune responses than the wild-type peptide. The best-studied system to date is the decamer MART-1/Melan-A26–35 peptide, E
Autor:
Kim M. Miles, Bent K. Jakobsen, Anna Marta Bulek, Yi Li, Moushumi Hossain, Andrew K. Sewell, Malkit Sami, Brian M. Baker, Anna Fuller, Pierre J. Rizkallah, Nathaniel Liddy, Andrea J. A. Schauenburg, Christopher J. Holland, John J. Miles, David K. Cole, Florian Madura
Publikováno v:
The Journal of Biological Chemistry
Background: The molecular principles governing T-cell specificity are poorly understood. Results: High affinity binding of a melanoma-specific T-cell receptor (TCR) is mediated through new MHC contacts and distinct thermodynamics. Conclusion: A novel
Autor:
Andrea J. A. Schauenburg, David Price, David K. Cole, John J. Miles, Johanne M. Pentier, Andrew Trimby, Julia Ekeruche-Makinde, Hugo A. van den Berg, Ania Skowera, Mai Ping Tan, Jamie Rossjohn, Garry Dolton, Anna Marta Bulek, Tamsin Williams, Andrew K. Sewell, Kim M. Miles, Sian Llewellyn-Lacey, Mick Bailey, Linda Wooldridge, Mathew Clement, Pierre J. Rizkallah, Scott R. Burrows, Mark Peakman
Publikováno v:
Blood. 121:1112-1123
αβ-TCRs expressed at the CD8(+) T-cell surface interact with short peptide fragments (p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all aspects of CD8(+) T-cell immunity. However, the rules that govern the outco
Autor:
Anna Marta Bulek, David K. Cole, Christopher J. Holland, Andrew K. Sewell, Andrea J. A. Schauenburg, Florian Madura, Pierre J. Rizkallah, Anna Fuller
Publikováno v:
Journal of Immunological Methods
The interaction between the clonotypic αβ T cell receptor (TCR), expressed on the T cell surface, and peptide-major histocompatibility complex (pMHC) molecules, expressed on the target cell surface, governs T cell mediated autoimmunity and immunity
Autor:
Awen Gallimore, David K. Cole, Garry Dolton, John J. Miles, David Price, Scott R. Burrows, Tamsin Williams, Kristin Ladell, Julia Ekeruche-Makinde, Emily S.J. Edwards, Andrea J. A. Schauenburg, Andrew K. Sewell, Andrew James Godkin, Linda Wooldridge, Mathew Clement, Sarah Nicol Lauder
Publikováno v:
The Journal of Immunology. 187:654-663
CD8+ T-cells recognize immunogenic peptides presented at the cell surface bound to major histocompatibility complex class I (MHCI) molecules. Antigen recognition involves the binding of both T-cell receptor (TCR) and CD8 co-receptor to the same pepti