Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Andrea J, Pruijssers"'
Autor:
Samantha L. Grimes, Young J. Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Jennifer Gribble, Andrea J. Pruijssers, Maria L. Agostini, Alexandra Abu-Shmais, Xiaotao Lu, Seth A. Darst, Elizabeth Campbell, Mark R. Denison
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis. RDV resist
Externí odkaz:
https://doaj.org/article/351eda1dc8534b2e94fffb7f9053450a
Autor:
Jennifer Gribble, Laura J Stevens, Maria L Agostini, Jordan Anderson-Daniels, James D Chappell, Xiaotao Lu, Andrea J Pruijssers, Andrew L Routh, Mark R Denison
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009226 (2021)
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are
Externí odkaz:
https://doaj.org/article/526fcaa34c3442458c7bf131f0326706
Autor:
Gwen M. Taylor, Andrea J. Pruijssers, Pamela H. Brigleb, Kay L. Fiske, Pengcheng Shang, Kelly Urbanek, Judy J. Brown, Dhivyaa Rajasundaram, Terence S. Dermody
Publikováno v:
J Virol
Pathological effects of apoptosis associated with viral infections of the central nervous system are an important cause of morbidity and mortality. Reovirus is a neurotropic virus that causes apoptosis in neurons, leading to lethal encephalitis in ne
Autor:
Laura J. Stevens, Andrea J. Pruijssers, Hery W. Lee, Calvin J. Gordon, Egor P. Tchesnokov, Jennifer Gribble, Amelia S. George, Tia M. Hughes, Xiaotao Lu, Jiani Li, Jason K. Perry, Danielle P. Porter, Tomas Cihlar, Timothy P. Sheahan, Ralph S. Baric, Matthias Götte, Mark R. Denison
Publikováno v:
Science Translational Medicine. 14
The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Thus, it is critical to understand factors that promote or prevent
Autor:
Lisa A, Jackson, Evan J, Anderson, Nadine G, Rouphael, Paul C, Roberts, Mamodikoe, Makhene, Rhea N, Coler, Michele P, McCullough, James D, Chappell, Mark R, Denison, Laura J, Stevens, Andrea J, Pruijssers, Adrian, McDermott, Britta, Flach, Nicole A, Doria-Rose, Kizzmekia S, Corbett, Kaitlyn M, Morabito, Sijy, O'Dell, Stephen D, Schmidt, Phillip A, Swanson, Marcelino, Padilla, John R, Mascola, Kathleen M, Neuzil, Hamilton, Bennett, Wellington, Sun, Etza, Peters, Mat, Makowski, Jim, Albert, Kaitlyn, Cross, Wendy, Buchanan, Rhonda, Pikaart-Tautges, Julie E, Ledgerwood, Barney S, Graham, John H, Beigel, Gordon, Bernard
Publikováno v:
The New England Journal of Medicine
New England Journal of Medicine
New England Journal of Medicine
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized pre
Autor:
Laura J. Stevens, Andrea J. Pruijssers, Hery W. Lee, Calvin J. Gordon, Egor P. Tchesnokov, Jennifer Gribble, Amelia S. George, Tia M. Hughes, Xiaotao Lu, Jiani Li, Jason K. Perry, Danielle P. Porter, Tomas Cihlar, Timothy P. Sheahan, Ralph S. Baric, Matthias Götte, Mark R. Denison
The nucleoside analog remdesivir (RDV) is an FDA-approved antiviral for the treatment of SARS- CoV-2 infections, and as such it is critical to understand potential genetic determinants and barriers to RDV resistance. In this study, SARS-CoV-2 was sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4334c5467fcf3649207055e036eef987
https://doi.org/10.1101/2022.01.25.477724
https://doi.org/10.1101/2022.01.25.477724
Autor:
Amarendra, Pegu, Sarah E, O'Connell, Stephen D, Schmidt, Sijy, O'Dell, Chloe A, Talana, Lilin, Lai, Jim, Albert, Evan, Anderson, Hamilton, Bennett, Kizzmekia S, Corbett, Britta, Flach, Lisa, Jackson, Brett, Leav, Julie E, Ledgerwood, Catherine J, Luke, Mat, Makowski, Martha C, Nason, Paul C, Roberts, Mario, Roederer, Paulina A, Rebolledo, Christina A, Rostad, Nadine G, Rouphael, Wei, Shi, Lingshu, Wang, Alicia T, Widge, Eun Sung, Yang, John H, Beigel, Barney S, Graham, John R, Mascola, Mehul S, Suthar, Adrian B, McDermott, Nicole A, Doria-Rose, Jae, Arega, Wendy, Buchanan, Mohammed, Elsafy, Binh, Hoang, Rebecca, Lampley, Aparna, Kolhekar, Hyung, Koo, Catherine, Luke, Mamodikoe, Makhene, Seema, Nayak, Rhonda, Pikaart-Tautges, Janie, Russell, Elisa, Sindall, Pratap, Kunwar, Evan J, Anderson, Amer, Bechnak, Mary, Bower, Andres F, Camacho-Gonzalez, Matthew, Collins, Ana, Drobeniuc, Venkata Viswanadh, Edara, Srilatha, Edupuganti, Katharine, Floyd, Theda, Gibson, Cassie M Grimsley, Ackerley, Brandi, Johnson, Satoshi, Kamidani, Carol, Kao, Colleen, Kelley, Hollie, Macenczak, Michele Paine, McCullough, Etza, Peters, Varun K, Phadke, Nadine, Rouphael, Erin, Scherer, Amy, Sherman, Kathy, Stephens, Mehgan, Teherani, Jessica, Traenkner, Juton, Winston, Inci, Yildirim, Lee, Barr, Joyce, Benoit, Barbara, Carste, Joe, Choe, Maya, Dunstan, Roxanne, Erolin, Jana, Ffitch, Colin, Fields, Lisa A, Jackson, Erika, Kiniry, Susan, Lasicka, Stella, Lee, Matthew, Nguyen, Stephanie, Pimienta, Janice, Suyehira, Michael, Witte, Nedim Emil, Altaras, Andrea, Carfi, Marjorie, Hurley, Rolando, Pajon, Wellington, Sun, Tal, Zaks, Rhea N, Coler, Sasha E, Larsen, Kathleen M, Neuzil, Lisa C, Lindesmith, David R, Martinez, Jennifer, Munt, Michael, Mallory, Caitlin, Edwards, Ralph S, Baric, Nina M, Berkowitz, Eli A, Boritz, Kevin, Carlton, Pamela, Costner, Adrian, Creanga, Daniel C, Douek, Martin, Gaudinski, Ingelise, Gordon, LaSonji, Holman, Kwanyee, Leung, Bob C, Lin, Mark K, Louder, Kaitlyn M, Morabito, Laura, Novik, Sarah, O'Connell, Marcelino, Padilla, Phillip A, Swanson, Yi, Zhang, James D, Chappell, Mark R, Denison, Tia, Hughes, Xiaotao, Lu, Andrea J, Pruijssers, Laura J, Stevens, Christine M, Posavad, Michael, Gale, Vineet, Menachery, Pei-Yong, Shi
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, and the durability of such responses has not been previously reported. Here, we present a comprehensive assessment of the impact of variants B.1.1.7, B.1.351, P.1, B.1.429
Autor:
Mark R. Denison, Andrea J. Pruijssers
Publikováno v:
Current Opinion in Virology
Highlights • Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections. • Nucleoside analogues are highly active across multiple virus families. • CoVs encode a proofreading exoribonuclease that opposes inhibition b
Autor:
Andrea J. Pruijssers, Pengcheng Shang, Judy J. Brown, Pamela H Brigleb, Gwen M. Taylor, Terence S. Dermody, Kelly Urbanek
Pathological effects of apoptosis associated with viral infections of the central nervous system are an important cause of morbidity and mortality. Reovirus is a neurotropic virus that causes apoptosis in neurons, leading to lethal encephalitis in ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264feb5bef9e25002fa256d0f2f92bd5
https://doi.org/10.1101/2020.08.05.238220
https://doi.org/10.1101/2020.08.05.238220
Autor:
Laura J. Stevens, Mark R. Denison, Alexandra Schäfer, James D. Chappell, Bin Ma, David R. Martinez, Maria L. Agostini, Jason K. Perry, Rachel L. Graham, John P. Bilello, Jared Pitts, Kendra Gully, Danielle Porter, Ariane J. Brown, Eisuke Murakami, Venice Du Pont, Timothy P. Sheahan, Sarah R. Leist, Kenneth H. Dinnon, Darius Babusis, Boyd Yount, Lisa E. Gralinksi, Tia M. Hughes, Ralph S. Baric, Joy Y. Feng, Xiaotao Lu, Andrea J. Pruijssers, Tomas Cihlar, Amelia S. George
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 as the causative agent of the novel pandemic viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for safe, broad-spectrum antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d39047893773d908934086bdfb9634