Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Andrea Itano"'
Autor:
Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica S. Klaassen, Ahnjili Zhuparris, Andrea Itano, Mark Bodmer, Duncan McHale, Matthijs Moerland
Publikováno v:
Medicine in Microecology, Vol 19, Iss , Pp 100088- (2024)
Introduction: EDP1815 is a single-strain of Prevotella histicola with preclinical immunomodulatory properties. The aim of this study was to evaluate pharmacodynamic effects of EDP1815 on the immune response following immunization with keyhole limpet
Externí odkaz:
https://doaj.org/article/7384d8fe451f4d93a0aae74c68fc89e7
Autor:
Andrea Itano, Douglas Maslin, Kritika Ramani, Golbarg Mehraei, Nancy Carpenter, Taylor Cormack, Mahdi Saghari, Matthijs Moerland, Erin Troy, Will Caffry, Leslie Wardwell-Scott, Stuart Abel, Duncan McHale, Mark Bodmer
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionEDP1815 is a non-colonizing pharmaceutical preparation of a single stain of Prevotella histicola isolated from the duodenum of a human donor. We report here preclinical and clinical studies showing that the action of EDP1815, an orally de
Externí odkaz:
https://doaj.org/article/58a36d8358ba4116a6197826718313a9
Autor:
Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica S. Klaassen, Andrea Itano, Duncan McHale, Matthijs Moerland
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionLactococcus lactis spp. cremoris has been associated with promising immunomodulatory results in preclinical trials. The aim of this study was to investigate the pharmacodynamic (PD) effects of three monoclonal microbial formulations of L.
Externí odkaz:
https://doaj.org/article/d30c39786f8e495ca6dd73717dc49491
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
This Perspective presents the potential of the Small Intestinal Axis, a sub-division of the Gut-immune Axis, to modulate systemic inflammation based on sensing contents of the gut lumen. Gut mucosal immunity regulates tolerance to food and gut conten
Externí odkaz:
https://doaj.org/article/821e647d816a4202813fbe8b3147ea6f
Autor:
Kritika Ramani, Taylor Cormack, Adam N. R. Cartwright, Aula Alami, Pooja Parameswaran, Marynawal Abdou, Iris Wang, Kristie Hilliard-Barth, Shannon Argueta, Divya Raghunathan, Will Caffry, Christopher J. H. Davitt, Fabian B. Romano, Aylwin Ng, Valeria Kravitz, Tyler Rommel, Maria Sizova, Esra Uckun Kiran, Pallavi Pradeep, Holly E. Ponichtera, Tanmoy Ganguly, Mark Bodmer, Andrea Itano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The gastrointestinal tract represents one of the largest body surfaces that is exposed to the outside world. It is the only mucosal surface that is required to simultaneously recognize and defend against pathogens, while allowing nutrients containing
Externí odkaz:
https://doaj.org/article/b106e0454a704b4281ad9b357e8fb702
Autor:
Kritika Ramani, Taylor Cormack, Adam Cartwright, Aula Alami, Shannon Argueta, Divya Raghunathan, Mary Abdou, Fabian B Romano, Valeria Kravitz, Tyler Rommel, Esra Uckun Kiran, Pallavi Pradeep, Holly Ponichtera, Maria Sizova, Tanmoy Ganguly, Andrea Itano
Publikováno v:
The Journal of Immunology. 208:113.08-113.08
Introduction The mucosal immune system comprises of a complex network of intestinal epithelial cells and immune cells. We report that an orally delivered microbial strain of Veillonella parvula (EDP1867) that is non-replicating and non-colonizing act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ebfda0e20195c51a79ec4a05d9082a
https://doi.org/10.4049/jimmunol.208.supp.113.08
https://doi.org/10.4049/jimmunol.208.supp.113.08
Autor:
Shannon Argueta, Adam Cartwright, Kritika Ramani, Taylor Cormack, Fabian Romano Chernac, Kristie Hilliard-Barth, Aula Alami, Divya Raghunathan, Mihika Jalan, Will Caffry, Jake Keats, Krutika Invally, Bin Wang, Valeria Kravitz, Tyler Rommel, Tanmoy Ganguly, Holly Ponichtera, Mark Bodmer, Andrea Itano
Publikováno v:
The Journal of Immunology. 206:66.10-66.10
The small intestinal axis is a network of anatomical and functional connections linking the small intestine with the rest of the body. It senses external signals in the gut lumen and translates them into systemic immune effects. We have previously sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175d53ac3d71c71720e4c2bfe881a9e8
https://doi.org/10.4049/jimmunol.206.supp.66.10
https://doi.org/10.4049/jimmunol.206.supp.66.10
Autor:
Kevin Gaida, Xuxia Zhang, Robin Elliott, Benxian Liu, Andrea Itano, Cynthia Park, Justin K. Murray, Colin V. Gegg, Jennifer Aral, Les P. Miranda, Joseph G. McGivern, Hongyan Li, Anne Colombero, E. Allen Sickmier, Kevin Salyers, Michael Stenkilsson, Jonathan Werner, Steven Yu, Mark J. Rose, John K. Sullivan, Yi-Xin Qian, Peter Miu, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 58:6784-6802
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ed4b88835ea36a6e04bf82dabb3f1f
https://doi.org/10.1021/acs.jmedchem.5b00495
https://doi.org/10.1021/acs.jmedchem.5b00495
Autor:
Andrew Tasker, Andrea Itano, Anu Gore, Paul E. Harrington, Mike Frohn, Victor J. Cee, Michele McElvain, Min Wong, Mike Fiorino, Alexander J. Pickrell, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Anthony B. Reed, Yang Xu, Susana C. Neira, Scot Middleton, Henry Morrison
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1779-1783
Replacement of the azetidine carboxylate of an S1P1 agonist development candidate, AMG 369, with a range of acyclic head-groups led to the identification of a novel, S1P3-sparing S1P1 agonist, (−)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f3cc5bea5e6a249ac305b5230ca5f2
https://doi.org/10.1016/j.bmcl.2011.12.073
https://doi.org/10.1016/j.bmcl.2011.12.073
Autor:
Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:107-112
The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469aac7dbf0531b12b4eec83f252b55d
https://doi.org/10.1021/ml100306h
https://doi.org/10.1021/ml100306h