S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration

Autor: Mustafa Sindi, Christina Hecker, Andrea Issberner, Tobias Ruck, Sven G. Meuth, Philipp Albrecht, Michael Dietrich

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionIn multiple sclerosis (MS), chronic disability primarily stems from axonal and neuronal degeneration, a condition resistant to conventional immunosuppressive or immunomodulatory treatments. Recent research has indicated that selective sph

Externí odkaz: https://doaj.org/article/953fbe3b51dc4d16831d9fa78a3c884c

Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy

Autor: Moritz J. Frenger, Christina Hecker, Mustafa Sindi, Andrea Issberner, Hans-Peter Hartung, Sven G. Meuth, Michael Dietrich, Philipp Albrecht

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Confocal scanning laser ophthalmoscopy (cSLO) is a non-invasive technique for real-time imaging of the retina. We developed a step-by-step protocol for the semi-automatic evaluation of myeloid cells in cSLO images from CX3CR1GFP mice, expressing gree

Externí odkaz: https://doaj.org/article/cfd2c4927eaa4454affd76aac0421461

Neuroprotective Properties of Dimethyl Fumarate Measured by Optical Coherence Tomography in Non-inflammatory Animal Models

Autor: Michael Dietrich, Christina Hecker, Milad Nasiri, Sogol Samsam, Andrea Issberner, Zippora Kohne, Hans-Peter Hartung, Philipp Albrecht

Publikováno v: Frontiers in Neurology, Vol 11 (2021)

While great advances have been made in the immunomodulatory treatment of multiple sclerosis (MS), there is still an unmet need for drugs with neuroprotective potential. Dimethyl fumarate (DMF) has been suggested to exert both immunomodulatory and neu

Externí odkaz: https://doaj.org/article/2af8400112cf49c58a66aa11bc396f0c

Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis

Autor: Praveena Manogaran, Sven Schippling, Friedemann Paul, Charlotte von Gall, Christina Hecker, Alexander U. Brandt, Julia Button, Lisanne J. Balk, Michael Dietrich, Philipp Albrecht, Benjamin Knier, Thomas Korn, Julia Steckel, Elisabeth D. Olbert, Christine Baksmeier, Hao Yiu, Orhan Aktas, Valeria Koska, Annemarie Heskamp, Shiv Saidha, Norbert Goebels, Alexander M. Hilla, Nuria Sola-Valls, Mark Stettner, Joachim Havla, Hannah G. Zimmermann, Patrick Küry, Natalia Gonzalez Caldito, Anne K. Mausberg, Carsten Berndt, Dietmar Fischer, Klaudia Lepka, Andrés Cruz-Herranz, Elena H. Martinez-Lapiscina, Angelika Hallenberger, Peter A. Calabresi, Hans-Peter Hartung, Ari J. Green, Peter Göttle, Andrea Issberner

Publikováno v: Brain : a journal of neurology, 143(3), 1127-1142
Dietrich, M, Koska, V, Hecker, C, Göttle, P, Hilla, A M, Heskamp, A, Lepka, K, Issberner, A, Hallenberger, A, Baksmeier, C, Steckel, J, Balk, L, Knier, B, Korn, T, Havla, J, Martínez-Lapiscina, E H, Solà-Valls, N, Manogaran, P, Olbert, E D, Schippling, S, Cruz-Herranz, A, Yiu, H, Button, J, Caldito, N G, von Gall, C, Mausberg, A K, Stettner, M, Zimmermann, H G, Paul, F, Brandt, A U, Küry, P, Goebels, N, Aktas, O, Berndt, C, Saidha, S, Green, A J, Calabresi, P A, Fischer, D, Hartung, H P & Albrecht, P 2020, ' Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis ', Brain : a journal of neurology, vol. 143, no. 3, pp. 1127-1142 . https://doi.org/10.1093/brain/awaa062

Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via block

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d1ea008257728b9f8a67916c0ec936
https://doi.org/10.1093/brain/awaa062

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