Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs

Autor: Andrea Ikeda Takahashi, Felipe Rebello Lourenço, Marcelo Dutra Duque, Vladi Olga Consiglieri, Humberto Gomes Ferraz

Publikováno v: Brazilian Archives of Biology and Technology, Vol 55, Iss 3, Pp 477-484 (2012)

In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and t

Externí odkaz: https://doaj.org/article/f77ab68830eb46efb06d04c94a33275d

Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process

Autor: Letícia Pessole, Michele Georges Issa, Newton Andréo Filho, Humberto Gomes Ferraz, Andrea Ikeda Takahashi

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 48, Issue: 3, Pages: 379-388, Published: SEP 2012
Brazilian Journal of Pharmaceutical Sciences; Vol. 48 No. 3 (2012); 379-388
Brazilian Journal of Pharmaceutical Sciences; Vol. 48 Núm. 3 (2012); 379-388
Brazilian Journal of Pharmaceutical Sciences; v. 48 n. 3 (2012); 379-388
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 48, Iss 3, Pp 379-388 (2012)

With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3729036ecf0839f80270a3cf8d81c1d
https://doi.org/10.1590/s1984-82502012000300004

Attainment and characterization of binary and ternary complexes of simvastatin and cyclodextrins

Autor: Andrea Ikeda Takahashi

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

O objetivo do presente trabalho foi obter complexos binários e ternários de sinvastatina (SNV) e ciclodextrinas (CDs) utilizando diferentes tipos de CDs, métodos de secagem e polímeros para selecionar aquele que proporcionam um maior aumento da s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268cd9c8766f2834bff5bb67c076da79