Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrea Hoelbl-Kovacic"'
Autor:
Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signal
Externí odkaz:
https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
Autor:
Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Thanh Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Recurrent gain-of-function mutations in the transcription factors STAT5A and much more in STAT5B were found in hematopoietic malignancies with the highest proportion in mature T- and natural killer-cell neoplasms (peripheral T-cell lymphoma, PTCL). N
Externí odkaz:
https://doaj.org/article/7219ee938f624a009dceae930c2be567
Autor:
Angela Schumich, Michaela Prchal-Murphy, Margarita Maurer-Granofszky, Andrea Hoelbl-Kovacic, Nora Mühlegger, Ulrike Pötschger, Sabine Fajmann, Oskar A. Haas, Karin Nebral, Nils von Neuhoff, Martin Zimmermann, Heidrun Boztug, Mareike Rasche, Marlies Dolezal, Christiane Walter, Dirk Reinhardt, Veronika Sexl, Michael N. Dworzak
Publikováno v:
HemaSphere, Vol 4, Iss 1, p e312 (2020)
Abstract. Aberrant activation of key signaling-molecules is a hallmark of acute myeloid leukemia (AML) and may have prognostic and therapeutic implications. AML summarizes several disease entities with a variety of genetic subtypes. A comprehensive m
Externí odkaz:
https://doaj.org/article/86d754cbc853436596952dc60b4e601c
Autor:
Boris Kovacic, Andrea Hoelbl-Kovacic, Katrin M. Fischhuber, Nicole R. Leitner, Dagmar Gotthardt, Emilio Casanova, Veronika Sexl, Mathias Müller
Publikováno v:
Haematologica, Vol 99, Iss 6 (2014)
Considerable effort has been expended to identify genes that account for myeloid lineage commitment and development. However, currently available non-invasive mouse models utilize myeloid-specific reporters that are significantly expressed in hematop
Externí odkaz:
https://doaj.org/article/959bff75593b41e5b0f511b21267e928
Autor:
Peter Valent, Veronika Sexl, Tessa L. Holyoake, Christine Mannhalter, Berthold Streubel, Wolfgang R. Sperr, Heinz Sill, Susanne Herndlhofer, Martin Bilban, Daniela Berger, Gabriele Stefanzl, Barbara Peter, Katharina Blatt, Georg Greiner, Gregor Hoermann, Wolfgang Warsch, Sabine Cerny-Reiterer, Gregor Eisenwort, Harald Herrmann, Andrea Hoelbl-Kovacic, Irina Sadovnik
Purpose: In chronic myelogenous leukemia (CML), leukemic stem cells (LSC) represent a critical target of therapy. However, little is known about markers and targets expressed by LSCs. The aim of this project was to identify novel relevant markers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a84454f8a162cfdea356acd3ec3175b
https://doi.org/10.1158/1078-0432.c.6524444.v1
https://doi.org/10.1158/1078-0432.c.6524444.v1
Autor:
Peter Valent, Veronika Sexl, Tessa L. Holyoake, Christine Mannhalter, Berthold Streubel, Wolfgang R. Sperr, Heinz Sill, Susanne Herndlhofer, Martin Bilban, Daniela Berger, Gabriele Stefanzl, Barbara Peter, Katharina Blatt, Georg Greiner, Gregor Hoermann, Wolfgang Warsch, Sabine Cerny-Reiterer, Gregor Eisenwort, Harald Herrmann, Andrea Hoelbl-Kovacic, Irina Sadovnik
Tables: S1 Specification of monoclonal antibodies (mAb) used in this study; S2 Patients´ characteristics - chronic myeloid leukemia (CML); S3 Patients´ characteristics - ormal/reactive BM; S4 Detection of BCR/ABL1 in sorted CML cells by FISH; S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91232377450f3c5123921c09bebd0558
https://doi.org/10.1158/1078-0432.22460267.v1
https://doi.org/10.1158/1078-0432.22460267.v1
Autor:
Philipp B. Staber, Florian Grebien, Johannes Zuber, Hubert Hackl, Rotraud Wieser, Andrea Hoelbl-Kovacic, Elisabeth Koller, Dagmar Stoiber, Katharina Bauer, Louise E. Purton, Anastasiya Hladik, Angela Schlerka, Chi Huu Nguyen
Publikováno v:
Cell Death and Disease, Vol 10, Iss 12, Pp 1-17 (2019)
Cell Death & Disease
Cell Death & Disease
Ecotropic virus integration site 1 (EVI1), whose overexpression characterizes a particularly aggressive subtype of acute myeloid leukemia (AML), enhanced anti-leukemic activities of all-trans retinoic acid (atRA) in cell lines and patient samples. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c588579389f1815d1615d133e734d8be
http://link.springer.com/article/10.1038/s41419-019-2172-2
http://link.springer.com/article/10.1038/s41419-019-2172-2
Autor:
Yanke Liang, Junia V. Melo, Karin Bauer, Ingeborg Menzl, Nicholas Kwiatkowski, Johannes Zuber, Vanessa M. Knab, Veronika Sexl, Michaela Prchal-Murphy, Tinghu Zhang, Stefan Kubicek, Peter Valent, Iris Z. Uras, Anna Skucha, Florian Grebien, Eva Grundschober, Gerwin Heller, Thomas Weichhart, Nathanael S. Gray, Angelika Berger-Becvar, Yao Liu, Mareike Roth, Daniela A. Fux, Andrea Hoelbl-Kovacic, Leo Edlinger, John M. Hatcher, Reinhard Grausenburger
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significantly enhances disease latency and prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2932886a8bb5546af466f37450724
http://link.springer.com/article/10.1038/s41467-019-12656-x
http://link.springer.com/article/10.1038/s41467-019-12656-x
Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
Autor:
Reinhard Grausenburger, Barbara Maurer, Sebastian Kollmann, Andrea Hoelbl-Kovacic, Leo Edlinger, Wolfgang Warsch, Lothar Hennighausen, Sabine Lagger, Jani Huuhtanen, Eva Grundschober, Peter Valent, Birgit Strobl, Veronika Sexl, Satu Mustjoki, Thomas Decker, Mathias Mueller
Publikováno v:
Leukemia
Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As mutations in STAT5B, but not STAT5A, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975a12c1dec933b01fcb0d6d8e9a220e
http://europepmc.org/articles/PMC6755975
http://europepmc.org/articles/PMC6755975
Autor:
Tania Brandstoetter, Gerwin Heller, Andrea Hoelbl-Kovacic, Reinhard Grausenburger, Markus Zojer, Isabella Maria Mayer, Leif Carlsson, Karoline Kollmann, Ingeborg Menzl, Barbara Maurer, Eszter Doma, Veronika Sexl
Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situationin vivo. We now report a robust method to generate and maintain LSK (lin-, Sca-1+, c-Ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087a32cd7dd707fc8d1f5eaf57aff72f
https://doi.org/10.1101/2020.10.05.325886
https://doi.org/10.1101/2020.10.05.325886