Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andrea Heldsinger"'
Autor:
Chung Owyang, Shi Yi Zhou, Xiaoyin Wu, Andrea Heldsinger, Il Song, Gintautas Grabauskas, Yuanxu Lu
Publikováno v:
The Journal of Physiology. 593:3973-3989
Ghrelin, a hunger signalling peptide derived from the peripheral tissues, overcomes the satiety signals evoked by anorexigenic molecules, such as cholecystokinin (CCK) and leptin, to stimulate feeding. Using in vivo and in vitro electrophysiological
Autor:
Andrea Heldsinger, Il Song, Xiaoyin Wu, Yuanxu Lu, Gintautas Grabauskas, Chung Owyang, Shi-Yi Zhou
Publikováno v:
Endocrinology. 155:3956-3969
The anorexigenic adipocyte-derived hormone leptin and the orexigenic hormone ghrelin act in opposition to regulate feeding behavior via the vagal afferent pathways. The mechanisms by which ghrelin exerts its inhibitory effects on leptin are unknown.
Autor:
Chung Owyang, Andrea Heldsinger
Publikováno v:
Journal of Neurogastroenterology and Motility
The paradigm for the control of feeding behavior has changed significantly. In this review, we present evidence that the separation of function in which cholecystokinin (CCK) controls short-term food intake and leptin regulate long-term eating behavi
Publikováno v:
Diabetes
OBJECTIVE Diabetic patients often experience visceral hypersensitivity and anorectal dysfunction. We hypothesize that the enhanced excitability of colon projecting dorsal root ganglia (DRG) neurons observed in diabetes is caused by a decrease in the
Publikováno v:
Journal of Biological Chemistry. 286:11707-11715
Research has shown that the synergistic interaction between vagal cholecystokinin-A receptors (CCKARs) and leptin receptors (LRbs) mediates short term satiety. We hypothesize that this synergistic interaction is mediated by cross-talk between signali
Autor:
Gintautas, Grabauskas, Xiaoyin, Wu, Yuanxu, Lu, Andrea, Heldsinger, Il, Song, Shi-Yi, Zhou, Chung, Owyang
Publikováno v:
The Journal of physiology. 593(17)
Ghrelin, a hunger signalling peptide derived from the peripheral tissues, overcomes the satiety signals evoked by anorexigenic molecules, such as cholecystokinin (CCK) and leptin, to stimulate feeding. Using in vivo and in vitro electrophysiological
Acid reflux in the esophagus can induce esophageal painful sensations such as heartburn and noncardiac chest pain. The mechanisms underlying acid-induced esophageal nociception are not clearly understood. In our previous studies, we characterized eso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a332318c95441e5e2193894129a668
https://europepmc.org/articles/PMC3920110/
https://europepmc.org/articles/PMC3920110/
Autor:
D.W. Moreland, Hoa N. Truong, Houng-Yau Mei, Lamia Sharmeen, Joseph A. Loo, Adam A. Galan, Kristin A. Sannes-Lowery, David P. Mack, Andrea Heldsinger, Anthony W. Czarnik, Nadia S. Halim
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1173-1184
We have developed a therapeutic program focusing on the inhibition of a human immunodeficiency virus-1 specific protein-RNA interaction. This program begins with a search for small organic molecules that would interfere with the binding of Tat protei
Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents
Autor:
Il Song, Moon Kyung Joo, Gintautas Grabauskas, Shizhong Zhang, Shaoyong Yu, Chung Owyang, Xiaoyin Wu, Andrea Heldsinger
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 304(10)
Sensitization of esophageal afferents plays an important role in esophageal nociception, but the mechanism is less clear. Our previous studies demonstrated that mast cell (MC) activation releases the preformed mediators histamine and tryptase, which
Autor:
Xiaoyin Wu, Gintautas Grabauskas, Andrea Heldsinger, Yuanxu Lu, Chung Owyang, Shi Yi Zhou, Il Song
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 303(9)
Vagal CCK-A receptors (CCKARs) and leptin receptors (LRbs) interact synergistically to mediate short-term satiety. Cocaine- and amphetamine-regulated transcript (CART) peptide is expressed by vagal afferent neurons. We sought to demonstrate that this