Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Andrea Hawe"'
Autor:
Brecht Vanbillemont, Anna-Lena Greiner, Vanessa Ehrl, Tim Menzen, Wolfgang Friess, Andrea Hawe
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100180- (2023)
Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the crit
Externí odkaz:
https://doaj.org/article/e764e9c5ffc64cc7acc9036b48afe182
Autor:
Cornelia Hiemenz, Nadine Baumeister, Constanze Helbig, Andrea Hawe, Sabrina Babutzka, Stylianos Michalakis, Wolfgang Friess, Tim Menzen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101162- (2023)
Recombinant adeno-associated viruses (rAAVs) are attractive therapeutic viral vectors for gene delivery. To ensure the efficacy and safety of rAAV-based therapies, comprehensive characterization of the adeno-associated virus (AAV) capsids is essentia
Externí odkaz:
https://doaj.org/article/021bc972a55c4085adb2165aff1ec1da
Autor:
Anian, Thaller, Lukas, Schmauder, Wolfgang, Frieß, Gerhard, Winter, Tim, Menzen, Andrea, Hawe, Klaus, Richter
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 182:152-156
During the SARS-CoV2 pandemic mRNA vaccines in the form of lipid nanoparticles (LNPs) containing the mRNA, have set the stage for a new area of vaccines. Analytical methods to quantify changes in size and structure of LNPs are crucial, as changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c94b54c4fc6d4661c06ffbd68e4670
https://doi.org/10.1016/j.ejpb.2022.11.014
https://doi.org/10.1016/j.ejpb.2022.11.014
Autor:
Klaus Richter, Christine Wurm, Kim Strasser, Jana Bauer, Maria Bakou, Ross VerHeul, Shawn Sternisha, Andrea Hawe, Michael Salomon, Tim Menzen, Akash Bhattacharya
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc543c2210f12b4aa3004a42aa53954c
https://doi.org/10.1016/j.ejpb.2023.05.011
https://doi.org/10.1016/j.ejpb.2023.05.011
Autor:
Cornelia Hiemenz, Anabel Pacios-Michelena, Constanze Helbig, Valerija Vezočnik, Michael Strebl, Felix Nikels, Andrea Hawe, Patrick Garidel, Tim Menzen
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86444f9491c173a029f52b0899db4b9a
https://doi.org/10.1016/j.xphs.2023.05.009
https://doi.org/10.1016/j.xphs.2023.05.009
Autor:
Sajal Manubhai Patel, Steven L. Nail, Michael J. Pikal, Raimund Geidobler, Gerhard Winter, Andrea Hawe, Juan Davagnino, Shailaja Rambhatla Gupta
Publikováno v:
Principles and Practices of Lyophilization in Product Development and Manufacturing ISBN: 9783031126338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4211d3809f2899d01a25df035f9847eb
https://doi.org/10.1007/978-3-031-12634-5_31
https://doi.org/10.1007/978-3-031-12634-5_31
Publikováno v:
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, 110(2), 952-958
Journal of Pharmaceutical Sciences, 110(2), 952-958
Sucrose is a commonly used stabilizing excipient in protein formulations. However, recent studies have indicated the presence of nanoparticulate impurities (NPIs) in the size range of 100-200 nm in pharmaceutical-grade sucrose. Furthermore, isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f2aec65e2a09541dbf19fe0a6214a2
https://doi.org/10.1016/j.xphs.2020.11.011
https://doi.org/10.1016/j.xphs.2020.11.011
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 153:84-94
Freeze-drying methodology requires an in-depth understanding and characterization for optimal processing of biopharmaceuticals. Particularly the primary drying phase, the longest and most expensive stage of the process, is of interest for optimizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a87e21755e2d3e19cc0f588e08432
https://doi.org/10.1016/j.ejpb.2020.05.028
https://doi.org/10.1016/j.ejpb.2020.05.028
Autor:
Mona Abdel-Tawab, Markus Waßmuth, Florian Gegenfurtner, Andrea Hawe, Jan H Schefe, Anke M Strunz, Joachim Wübert
Publikováno v:
European journal of hospital pharmacy : science and practice.
Aggregation is one of the key critical points limiting the stability of monoclonal antibodies in solution. The present study aimed to investigate the in-use stability of a residual monoclonal antibody solution after withdrawal of most of the filling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdae9c7317d34a429b104985a9a35afb
https://pubmed.ncbi.nlm.nih.gov/35853692
https://pubmed.ncbi.nlm.nih.gov/35853692
Publikováno v:
International journal of pharmaceutics. 621
The complexity of biopharmaceuticals requires often the freeze-drying as stabilizing process. Inadequate parameters in the primary drying phase can impair product quality, besides, increasing time and costs. Therefore, the process requires a thorough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4974ea8b752b90eba78a29f4e136ad
https://pubmed.ncbi.nlm.nih.gov/35472509
https://pubmed.ncbi.nlm.nih.gov/35472509