Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrea Harkin"'
Autor:
Marta Nowak, Faiz Jabbar, Ann-Katrin Rodewald, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Rachel Kerr, Karin Oein, Noori Maka, Jennifer Hay, Joanne Edwards, Ian Tomlinson, Owen Sansom, Caroline Kelly, Francesco Pezzella, David Kerr, Alistair Easton, Enric Domingo, Viktor H. Koelzer, David N. Church, Bengt Glimelius, Ismail Gogenur, Emma Jaeger, Hannah Morgan, Clare Orange, Claire Palles, Campbell Roxburgh
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101727- (2024)
Summary: Testing for DNA mismatch repair deficiency (MMRd) is recommended for all colorectal cancers (CRCs). Automating this would enable precision medicine, particularly if providing information on etiology not captured by deep learning (DL) methods
Externí odkaz:
https://doaj.org/article/0addef455aaa46a896ad776bd6ad5c75
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Anja L Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim J Iveson, Mark Saunders, Karin Oein, Noori Maka, Francesco Pezella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen J Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel S Kerr, David J Kerr, Håvard E Danielsen, Enric Domingo, TransSCOT Consortium, David N Church, Viktor H Koelzer
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 6, Pp 449-463 (2023)
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple i
Externí odkaz:
https://doaj.org/article/d2fd350d290249e6b38f3b09f966ff54
Autor:
Antonia K Roseweir, James H Park, Sanne ten Hoorn, Arfon GMT Powell, Susan Aherne, Campbell SD Roxburgh, Donald C McMillan, Paul G Horgan, Elizabeth Ryan, Kieran Sheahan, Louis Vermeulen, James Paul, Andrea Harkin, Janet Graham, Owen Sansom, David N Church, Ian Tomlinson, Mark Saunders, Tim J Iveson, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, c
Externí odkaz:
https://doaj.org/article/86ccccce88334b4890153382c13043e0
Autor:
Philip J. Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Peter Broderick, James Studd, Juan Fernandez-Tajes, Susan Farrington, Victoria Svinti, Claire Palles, Giulia Orlando, Amit Sud, Amy Holroyd, Steven Penegar, Evropi Theodoratou, Peter Vaughan-Shaw, Harry Campbell, Lina Zgaga, Caroline Hayward, Archie Campbell, Sarah Harris, Ian J. Deary, John Starr, Laura Gatcombe, Maria Pinna, Sarah Briggs, Lynn Martin, Emma Jaeger, Archana Sharma-Oates, James East, Simon Leedham, Roland Arnold, Elaine Johnstone, Haitao Wang, David Kerr, Rachel Kerr, Tim Maughan, Richard Kaplan, Nada Al-Tassan, Kimmo Palin, Ulrika A. Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G. Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Daniel D. Buchanan, Aung-Ko Win, John Hopper, Mark E. Jenkins, Noralane M. Lindor, Polly A. Newcomb, Steven Gallinger, David Duggan, Graham Casey, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Douglas F. Easton, Paul D. P. Pharoah, Julian Peto, Federico Canzian, Anthony Swerdlow, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, The PRACTICAL consortium, Andrea Harkin, Karen Allan, John McQueen, James Paul, Timothy Iveson, Mark Saunders, Katja Butterbach, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Iva Kirac, Petar Matošević, Philipp Hofer, Stefanie Brezina, Andrea Gsur, Jeremy P. Cheadle, Lauri A. Aaltonen, Ian Tomlinson, Richard S. Houlston, Malcolm G. Dunlop
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17
Externí odkaz:
https://doaj.org/article/70e8e953edd64bddb89636d55f3bc15c
Autor:
Timothy Iveson, Kathleen A Boyd, Rachel S Kerr, Jose Robles-Zurita, Mark P Saunders, Andrew H Briggs, Jim Cassidy, Niels Henrik Hollander, Josep Tabernero, Andrew Haydon, Bengt Glimelius, Andrea Harkin, Karen Allan, John McQueen, Sarah Pearson, Ashita Waterston, Louise Medley, Charles Wilson, Richard Ellis, Sharadah Essapen, Amandeep S Dhadda, Mark Harrison, Stephen Falk, Sherif Raouf, Charlotte Rees, Rene K Olesen, David Propper, John Bridgewater, Ashraf Azzabi, David Farrugia, Andrew Webb, David Cunningham, Tamas Hickish, Andrew Weaver, Simon Gollins, Harpreet Wasan, James Paul
Publikováno v:
Health Technology Assessment, Vol 23, Iss 64 (2019)
Background: Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high-risk stage II or III colorectal cancer. However, the regimen is associated with cumulative toxicity, characte
Externí odkaz:
https://doaj.org/article/4215111445164519a465163178fd46e0
Autor:
Mark P. Saunders, Rohan Iype, Caroline Kelly, Jana Crosby, Rachel Kerr, Andrea Harkin, Karen Allan, John McQueen, Sarah R Pearson, James Cassidy, Louise C. Medley, Sherif Raouf, Mark Harrison, Alison Brewster, Charlotte Rees, Richard Ellis, Anne L. Thomas, Mark Churn, Timothy Iveson, Noori Maka
Publikováno v:
Clinical Colorectal Cancer. 22:231-237
Autor:
Anja Laura Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Karin Oien, Noori Maka, Francesco Pezzella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel Kerr, David Kerr, Havard Emil Danielsen, Enric Domingo, David N Church, Viktor Hendrik Koelzer
Background: Tumour immunoprofiling captures tumour-microenvironment interactions and enables precision medicine. Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8335b8a6f4dafad80bfbed52bc50e1
https://doi.org/10.1101/2023.05.19.23290216
https://doi.org/10.1101/2023.05.19.23290216
Design: Phase III, randomised controlled, two arm, open label, multicentre, non-inferiority. Objectives: Assessment of the efficacy of 12 weeks versus 24 weeks of treatment and associated toxicity. Economic analysis of the cost effectiveness of the 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52d986cb7d8efc6501c23bc93402742
https://doi.org/10.17504/protocols.io.b8qvrvw6
https://doi.org/10.17504/protocols.io.b8qvrvw6
Autor:
Louis Vermeulen, Antonia K. Roseweir, Ian Tomlinson, Paul G. Horgan, Janet Graham, Donald C. McMillan, Sanne ten Hoorn, Elizabeth Ryan, David N. Church, Arfon Powell, Susan Aherne, Joanne Edwards, Owen J. Sansom, James Paul, Timothy Iveson, Campbell S.D. Roxburgh, Mark N. K. Saunders, Kieran Sheahan, James H. Park, Andrea Harkin
Publikováno v:
journal of pathology. Clinical research, 6(4), 283-296. Wiley-Blackwell Publishing Ltd
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Roseweir, A K, Park, J H, Hoorn, S T, Powell, A G, Aherne, S, Roxburgh, C S, Mcmillan, D C, Horgan, P G, Ryan, E, Sheahan, K, Vermeulen, L, Paul, J, Harkin, A, Graham, J, Sansom, O, Church, D N, Tomlinson, I, Saunders, M, Iveson, T J & Edwards, J 2020, ' Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.171, https://doi.org/10.1002/cjp2.171
The Journal of Pathology: Clinical Research
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Roseweir, A K, Park, J H, Hoorn, S T, Powell, A G, Aherne, S, Roxburgh, C S, Mcmillan, D C, Horgan, P G, Ryan, E, Sheahan, K, Vermeulen, L, Paul, J, Harkin, A, Graham, J, Sansom, O, Church, D N, Tomlinson, I, Saunders, M, Iveson, T J & Edwards, J 2020, ' Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.171, https://doi.org/10.1002/cjp2.171
The Journal of Pathology: Clinical Research
Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, clinical u