Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andrea Haegebart"'
Autor:
Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth, Carlo Stresemann
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Introduction The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multien
Externí odkaz:
https://doaj.org/article/3561698be7814f2aae47a490812fea48
Autor:
Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Mutant IDH1 (mIDH1) inhibitors have shown single-agent activity in relapsed/refractory AML, though most patients eventually relapse. We evaluated the efficacy and molecular mechanism of the combination treatment with azacitidine, which is currently t
Externí odkaz:
https://doaj.org/article/64b0bb93a8d94cbca64e4eba9c21cc0f
Autor:
Anja Füllgrabe, Simon Joost, Alexandra Are, Tina Jacob, Unnikrishnan Sivan, Andrea Haegebarth, Sten Linnarsson, Benjamin D. Simons, Hans Clevers, Rune Toftgård, Maria Kasper
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 843-855 (2015)
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study, we used multicolor lineage tracing to mark Lgr6-expr
Externí odkaz:
https://doaj.org/article/236350be9ef3410da8d307bbf455eb10
Autor:
Andreas Unterberg, Hartmut Rehwinkel, Ann Christin Beck, Felix Sahm, Michael Platten, Daniel Schrimpf, Stefan Kaulfuss, Wolfgang Wick, Olaf Panknin, Holger Hess-Stumpp, Roland Neuhaus, Roman C. Hillig, Judith Guenther, David Capper, Andrea Haegebart, Luisella Toschi, Markus Bauser, Stefan Pusch, Manfred Jugold, Martina Ott, Christel Herold-Mende, Katja Zimmermann, Jörg Balss, Jessica Eisel, Sonja Krausert, Viktoria Eichwald, Viktoria Fischer, Andreas von Deimling
Publikováno v:
Acta Neuropathologica. 133:629-644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These mutations result in a neomorphic enzyme specificity which leads to a dramatic