Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrea Habsid"'
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f
Autor:
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kevin R. Brown, Henry Ward, Maximilian Billmann, Kamaldeep Aulakh, Audrey Astori, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Shuye Pu, Andrea Habsid, Amy Hin Yan Tong, Natasha Christie-Holmes, Patrick Budylowski, Ayoob Ghalami, Samira Mubareka, Finlay Maguire, Arinjay Banerjee, Karen L. Mossman, Jack Greenblatt, Scott D. Gray-Owen, Brian Raught, Benjamin J. Blencowe, Mikko Taipale, Chad Myers, Jason Moffat
Publikováno v:
Heliyon, Vol 9, Iss 1, Pp e12744- (2023)
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor dependencies ma
Externí odkaz:
https://doaj.org/article/1fc0974096af4f23af93d99b3d0085a0
Autor:
Traver Hart, Amy Hin Yan Tong, Katie Chan, Jolanda Van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery Noonan, Andrea Habsid, Olga Sizova, Lyudmila Nedyalkova, Ryan Climie, Leanne Tworzyanski, Keith Lawson, Maria Augusta Sartori, Sabriyeh Alibeh, David Tieu, Sanna Masud, Patricia Mero, Alexander Weiss, Kevin R. Brown, Matej Usaj, Maximilian Billmann, Mahfuzur Rahman, Michael Constanzo, Chad L. Myers, Brenda J. Andrews, Charles Boone, Daniel Durocher, Jason Moffat
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2719-2727 (2017)
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used
Externí odkaz:
https://doaj.org/article/d4b448c162324c49bda2645179b12775
Autor:
Barbara Mair, Jelena Tomic, Sanna N. Masud, Peter Tonge, Alexander Weiss, Matej Usaj, Amy Hin Yan Tong, Jamie J. Kwan, Kevin R. Brown, Emily Titus, Michael Atkins, Katherine S.K. Chan, Lise Munsie, Andrea Habsid, Hong Han, Marion Kennedy, Brenda Cohen, Gordon Keller, Jason Moffat
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 599-615.e12 (2019)
Summary: Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves systemati
Externí odkaz:
https://doaj.org/article/b48e7be0191349729bde89c8056e0021
Autor:
Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, Yuwei Zhang, Bram Bussin, Adrian Granda Farias, Abdullah M. Syed, Katherine Chan, Andrea Habsid, Jason Moffat, Warren C. W. Chan
Publikováno v:
Nature Chemical Biology. 18:1023-1031
Nanotechnology provides platforms to deliver medical agents to specific cells. However, the nanoparticle's surface becomes covered with serum proteins in the blood after administration despite engineering efforts to protect it with targeting or block
Autor:
Andrea Habsid, Traver Hart, Catherine Ross, Hong Han, Chloe J. Slater, Donald M. Simons, Rummy Akthar, Shirley Hui, David Tieu, Gromoslaw A. Smolen, Abdelrahman Abou Zid, Amy Hin Yan Tong, Yuxi Yao, Patricia Mero, Gillian Kingsbury, Eiru Kim, Ryan Climie, Jordan A. Krall, Joseph J. Caumanns, Kevin R. Brown, Ren Li, Charles Kung, Michael Aregger, Jiarun Wei, Keith A. Lawson, Richa Singh, Zi Peng Fan, Lujia Tang, Xiaoyu Zhang, Sarah Martin, Laurie Ailles, Gary D. Bader, Jason Moffat, Qian Huang, Victor De Jesus, Elizabeth Ann Francis, Nicholas Mikolajewicz, Cristovão M. Sousa, John H. Brumell, Katherine S. K. Chan, Joshua E. Goldford, Antonio Finelli, Xiaowei Wang
Publikováno v:
Nature
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1–3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by
Autor:
Maximillian Billmann, Zhen Yuan Lin, Katherine Chan, Kevin R. Brown, Chad L. Myers, Mahfuzur Rahman, Amy Hin Yan Tong, Lucy Nedyalkova, Charles Boone, Hala Abdouni, Keith A. Lawson, Michael Costanzo, Alexander Weiss, Andrea Habsid, Cassandra J. Wong, Jason Moffat, Brenda J. Andrews, Patricia Mero, Olga Sizova, James W. Dennis, Anne-Claude Gingras, Judy Pawling, Matej Usaj, Michael Aregger, Catherine Ross
Publikováno v:
Nature metabolism
The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases, including cancer. Because cancer cells are intrinsically buffered to combat metabolic stress, it is important to understand how cells may adapt to the loss
Autor:
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kamaldeep Aulakh, Kevin R. Brown, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Amy Hin Yan Tong, Shuye Pu, Andrea Habsid, Natasha Christie-Holmes, Patrick Budylowski, Audrey Astori, Ayoob Ghalami, Samira Mubareka, Arinjay Banerjee, Karen L. Mossman, Jack Greenblatt, Scott D. Gray-Owen, Brian Raught, Benjamin J. Blencowe, Mikko Taipale, Jason Moffat
SUMMARYSARS-CoV-2, depends on host cell components for replication, therefore the identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection. Such host factors may be necessary for infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c404dd92076179177cbf643a9df0d18
https://doi.org/10.1101/2021.06.28.450244
https://doi.org/10.1101/2021.06.28.450244
Autor:
Melanie L, Bailey, David, Tieu, Andrea, Habsid, Amy Hin Yan, Tong, Katherine, Chan, Jason, Moffat, Philip, Hieter
Publikováno v:
Life Science Alliance
The context-dependency of genetic interactions of the cohesin gene STAG2, specifically STAG1 and the iron regulatory gene IREB2, are revealed by CRISPR-Cas9 screening in three different cellular backgrounds.
STAG2, a component of the mitotically
STAG2, a component of the mitotically
Autor:
Kevin R. Brown, Judy Pawling, Maximilian Billmann, Anne-Claude Gingras, Lyudmila Nedyalkova, Brenda J. Andrews, Charles Boone, Chad L. Myers, Matej Usaj, Alexander Weiss, Patricia Mero, Catherine Ross, Michael Aregger, Tong Ahy, Mahfuzur Rahman, Olga Sizova, Zhen-Yuan Lin, Keith A. Lawson, Michael Costanzo, Hala Abdouni, James W. Dennis, Jason Moffat, Katie Chan, Andrea Habsid
The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases including cancer. While several translational efforts have focused on direct perturbation of de novo fatty acid synthesis, only modest responses have been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26863bd492030ee6e5af01e9b8dfbfc