Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrea H. Epperly"'
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
Supplementary Fig. S2 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45f85ad8f9bf67422b660c7c3c6e9f
https://doi.org/10.1158/1535-7163.22486202
https://doi.org/10.1158/1535-7163.22486202
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
Supplementary Table S4 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59008ace3d1723e484a09b0c7583a1b8
https://doi.org/10.1158/1535-7163.22486187.v1
https://doi.org/10.1158/1535-7163.22486187.v1
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
With the development of targeted therapeutics, especially for small-molecule inhibitors, it is important to understand whether the observed in vivo efficacy correlates with the modulation of desired/intended target in vivo. We have developed a small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a2e897f6576dbb9b6e4c3b0107ed11
https://doi.org/10.1158/1535-7163.c.6532271
https://doi.org/10.1158/1535-7163.c.6532271
Autor:
Mehul Patel, Andrea H. Epperly, Gale Jennifer Paul, Pamela L. Golden, Hu Li, Frank T. Coppo, Daphne C. Clancy, Yue H. Li, Todd L. Graybill, David G. Tew, Francis X. Tavares, Joyce A. Boucheron, Stephen A. Thomson, Karen A. Evans, James E. Weiel, Maria Cichy-Knight, Sara H. Thrall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4068-4071
A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described. A solid-phase synthesis using Wang resin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9449c506d8423976e067252798e47af0
https://doi.org/10.1016/j.bmcl.2008.05.102
https://doi.org/10.1016/j.bmcl.2008.05.102
Autor:
Wendy Liu, James Marvin Veal, Deirdre K. Luttrell, Mui Cheung, Jeffrey A. Stafford, Robert T. Nolte, Robert N. Hunter, Jennifer H. Johnson, Renae M. Crosby, Liping Wang, Matthew L. Brown, Philip A. Harris, Rakesh Kumar, Andrea H. Epperly
Publikováno v:
Journal of Medicinal Chemistry. 48:1610-1619
A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhibitors of VEGFR2 kinase. Herein we describe the structure-activity relationship (SAR) of this novel template. Optimization of both aryl rings led to very potent inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a76992a3e9f11787a089af85f49e43
https://doi.org/10.1021/jm049538w
https://doi.org/10.1021/jm049538w
Autor:
C. G. Miller, J. A. Onori, Deirdre K. Luttrell, Rakesh Kumar, T. M. Hopper, Kevin Hinkle, Jennifer H. Johnson, I. K. Dev, Robert J. Mullin, K. M. Dold, R. E. Dornsife, Anne T. Truesdale, M. Cheung, Renae M. Crosby, Andrea H. Epperly, Jeffery Alan Stafford, L. E. Harrington
Publikováno v:
British Journal of Cancer
During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6238c5e9573828025868a85e954a97da
https://doi.org/10.1038/sj.bjc.6602109
https://doi.org/10.1038/sj.bjc.6602109
Autor:
Stephen A. Stimpson, David Kendall Jung, Andrea H. Epperly, Michael Robert Peel, Mui Cheung, Michael J. Alberti, Stanley D. Chamberlain, Jennifer Gabriel Badiang, Philip A. Harris, Stephanie Harris, Neal H. Bramson, Peckham Gregory
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5428-5430
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb95799ce4b8cbab3735d93a2dc8a3e
https://doi.org/10.1016/j.bmcl.2008.09.040
https://doi.org/10.1016/j.bmcl.2008.09.040
Autor:
Kimberly Nichols Noble, Todd W. Shearer, Jason D. Speake, Jonathan D. Hommel, Andrea E. Stroup, Luz Helena Carballo, Scott D. Sorensen, Tracy A. Brainard, Andrew Lamont Larkin, Aaron S. Goetz, Andrea H. Epperly, Julie C. Fisher, Diane M. Ignar, Joyce A. Boucheron
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 339(1)
μ-Opioid receptor (MOR) agonism induces palatable food consumption principally through modulation of the rewarding properties of food. N -{[3,5-difluoro-3′-(1 H -1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1 H -inden-2-amine (GSK1521498)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a9cd9527784a2bb70c837d6b46e415
https://pubmed.ncbi.nlm.nih.gov/21712426
https://pubmed.ncbi.nlm.nih.gov/21712426
Autor:
James M. Way, Lisa M. Leesnitzer, Jian Jin, Steven M. Sparks, Millard H. Lambert, Daniel D. Sternbach, Christy S. Britt, Raymond V. Merrihew, Robert X. Xu, Dongchuan Shi, Deborah A. Winegar, Andrea H. Epperly, Barry G. Shearer, Andrew N. Billin, David D. Wisnoski, Karen A. Evans
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(8)
A series of phenoxyacetic acids as subtype selective and potent hPPARδ partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bb35d95843a002b656ac31217e82a9
https://pubmed.ncbi.nlm.nih.gov/21414782
https://pubmed.ncbi.nlm.nih.gov/21414782
Autor:
Jason D. Speake, Cunyu Zhang, Michael J. Bishop, Luz H. Carballo, Susan Marie Westaway, Mike Hu, Aaron S. Goetz, Andrea H. Epperly
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(2)
Opioid receptors play an important role in both behavioral and homeostatic functions. We herein report tetrahydroquinoline derivatives as opioid receptor antagonists. SAR studies led to the identification of the potent antagonist 2v, endowed with 1.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb7920d6348306539054d68f00521d4
https://pubmed.ncbi.nlm.nih.gov/21193310
https://pubmed.ncbi.nlm.nih.gov/21193310