Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Andrea H. Ayscue"'
Autor:
Andrea H. Ayscue, Daniel D. Sternbach, Millard H. Lambert, Jennifer S. Smith, Timothy M. Willson, Brad R. Henke, Kelli D. Plunket, Kevin G. Liu, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2385-2388
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff87b476581b3a028bd00449b095f86
https://doi.org/10.1016/s0960-894x(01)00458-9
https://doi.org/10.1016/s0960-894x(01)00458-9
Autor:
Lisa M. Leesnitzer, Timothy M. Willson, Millard H. Lambert, Daniel D. Sternbach, Brad R. Henke, Kevin G. Liu, Kelli D. Plunket, Andrea H. Ayscue, Jennifer S. Smith
Publikováno v:
ChemInform. 32
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a4631c4a5a166f171acefb29aadeb2
https://doi.org/10.1002/chin.200152125
https://doi.org/10.1002/chin.200152125
Autor:
Andrea H. Ayscue, Brad R. Henke, Daniel D. Sternbach, Lisa M. Leesnitzer, William R. Oliver, Kevin G. Liu, Millard H. Lambert, Kelli D. Plunket, Timothy M. Willson, H. Eric Xu
Publikováno v:
ChemInform. 33
A series of PPARgamma agonists were synthesized from L-tyrosine that incorporated low molecular weight N-substituents. The most potent analogue, pyrrole (4e), demonstrated a K(i) of 6.9nM and an EC(50) of 4.7nM in PPARgamma binding and functional ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bff993215f1d4e2fa52d0368706a649
https://doi.org/10.1002/chin.200210167
https://doi.org/10.1002/chin.200210167
Autor:
Andrea H. Ayscue, Lisa M. Leesnitzer, Jason A. Holt, Shawn P. Williams, Thomas G. Consler, Andrew N. Billin, G. Bruce Wisely
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(9)
The ligand-binding domain (LBD) of apo-nuclear receptors in solution is thought to be a very dynamic structure with many possible conformations. Upon ligand binding, the structure is stabilized to a more rigid conformation. The dynamic stabilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600602f0e04247a6f977a44918ad8d5
https://pubmed.ncbi.nlm.nih.gov/12817079
https://pubmed.ncbi.nlm.nih.gov/12817079
Autor:
Andrea H. Ayscue, Daniel D. Sternbach, H. Eric Xu, Brad R. Henke, Timothy M. Willson, William R. Oliver, Millard H. Lambert, Kelli D. Plunket, Lisa M. Leesnitzer, Kevin G. Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(24)
A series of PPARgamma agonists were synthesized from L-tyrosine that incorporated low molecular weight N-substituents. The most potent analogue, pyrrole (4e), demonstrated a K(i) of 6.9nM and an EC(50) of 4.7nM in PPARgamma binding and functional ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff27df753fefab94d21fa0a13db7519b
https://pubmed.ncbi.nlm.nih.gov/11720854
https://pubmed.ncbi.nlm.nih.gov/11720854