Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andrea Gumiero"'
Autor:
Jeremy Sloan, Jana P. Hakenjos, Michael Gebert, Olga Ermakova, Andrea Gumiero, Gunter Stier, Klemens Wild, Irmgard Sinning, Jan U. Lohmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
WUSCHEL is a homeodomain transcription factor that is essential for stem cell maintenance in the plant shoot apical meristem. Here, via structural and biochemical approaches, Sloan et al. show that strong WUSCHEL binding to preferential target motifs
Externí odkaz:
https://doaj.org/article/4236df3e1fb04bd8b5f3b137806f34a3
Autor:
Felix Alexander Weyer, Andrea Gumiero, Karine Lapouge, Gert Bange, Jürgen Kopp, Irmgard Sinning
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
N-terminal acetylation is a common eukaryotic protein modification that is primarily catalysed by the N-acetyl transferase complex A (NatA). Here, the authors present the crystal structure of NatA bound to Huntingtin yeast two-hybrid protein K (HypK)
Externí odkaz:
https://doaj.org/article/9c328f88012a4a40805c0b5463ad51b5
Autor:
Andrea Gumiero, Charlotte Conz, Genís Valentín Gesé, Ying Zhang, Felix Alexander Weyer, Karine Lapouge, Julia Kappes, Ulrike von Plehwe, Géza Schermann, Edith Fitzke, Tina Wölfle, Tamás Fischer, Sabine Rospert, Irmgard Sinning
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
In yeast, the heterodimeric ribosome-associated complex (RAC) acts in concert with the Hsp70 protein Ssb, forming a unique chaperone triad. Here the authors use structural and biochemical approaches to shed light on how translation and folding are co
Externí odkaz:
https://doaj.org/article/26b640aed56d4e9cb16591f7ffb42612
Autor:
Irmgard Sinning, Olga Ermakova, Jana P Hakenjos, Michael Gebert, Jan U. Lohmann, Jeremy Sloan, Andrea Gumiero, Klemens Wild, Gunter Stier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
'Nature Communications ', vol: 11, pages: 2223-1-2223-16 (2020)
Nature Communications
'Nature Communications ', vol: 11, pages: 2223-1-2223-16 (2020)
Stem cells are one of the foundational evolutionary novelties that allowed the independent emergence of multicellularity in the plant and animal lineages. In plants, the homeodomain (HD) transcription factor WUSCHEL (WUS) is essential for the mainten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ba43c6f46e500a8e98b468fdcd8b28
Autor:
Ali Makky, Agatha Korytowski, Wolfgang Stremmel, Motomu Tanaka, Andrea Gumiero, Wasim Abuillan, Irmgard Sinning, Annika Gauss, Federico Amadei
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:959-965
The accumulation of phosphatidylcholine (PC) in the intestinal mucus layer is crucial for the protection of colon epithelia from the bacterial attack. It has been reported that the depletion of PC is a distinct feature of ulcerative colitis. Here we
Publikováno v:
'Nucleic Acids Research ', vol: 43, pages: 7083-7095 (2015)
Nucleic Acids Research
Nucleic Acids Research
The assembly of eukaryotic ribosomes is a hierarchical process involving about 200 biogenesis factors and a series of remodeling steps. The 5S RNP consisting of the 5S rRNA, RpL5 and RpL11 is recruited at an early stage, but has to rearrange during m
Autor:
Andrea, Gumiero, Andrea, Guimero, Sandip K, Badyal, Tina, Leeks, Peter C E, Moody, Emma Lloyd, Raven
Publikováno v:
Dalton Trans.. 42:3170-3175
We have previously demonstrated (Badyal et al., J. Biol. Chem., 2006, 281, 24512) that removal of the active site tryptophan (Trp41) in ascorbate peroxidase increases the conformational mobility of the distal histidine residue (His42) and that His42
Publikováno v:
Nature structuralmolecular biology. 24(2)
Cotranslational chaperones assist de novo folding of nascent polypeptides, prevent them from aggregating and modulate translation. The ribosome-associated complex (RAC) is unique in that the Hsp40 protein Zuo1 and the atypical Hsp70 chaperone Ssz1 fo
Autor:
Isabel K. Macdonald, Clive Metcalfe, Sandip K. Badyal, Igor Efimov, Peter C. E. Moody, Emma Lloyd Raven, Andrea Gumiero
We test the hypothesized pathway by which protons are passed from the substrate, ascorbate, to the ferryl oxygen in the heme enzyme ascorbate peroxidase (APX). The role of amino acid side chains and bound solvent is demonstrated. We investigated solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2badd05122d763b9d2cd39518ab3eb55
https://ora.ox.ac.uk/objects/uuid:66723f50-9e3c-4f1b-b866-dcd3347aaf63
https://ora.ox.ac.uk/objects/uuid:66723f50-9e3c-4f1b-b866-dcd3347aaf63
Autor:
Michael Towrie, Niall Simpson, Andrea Gumiero, Anthony W. Parker, Neil T. Hunt, Martin A. Walsh, Katrin Adamczyk, Gregory M. Greetham
Publikováno v:
Chemical Science
Ultrafast infrared spectroscopy provides insights into the dynamic nature of water in the active sites of catalase and peroxidase enzymes.
Understanding the impact of fast dynamics upon the chemical processes occurring within the active sites of
Understanding the impact of fast dynamics upon the chemical processes occurring within the active sites of