N-Acetylcarnosine Lubricant Eyedrops Possess All-In-One Universal Antioxidant Protective Effects of L-Carnosine in Aqueous and Lipid Membrane Environments, Aldehyde Scavenging, and Transglycation Activities Inherent to Cataracts: A Clinical Study of the New Vision-Saving Drug N-Acetylcarnosine Eyedrop Therapy in a Database Population of Over 50,500 Patients

Autor: Anne Kasus-Jacobi, Philip Micans, Andrea Guiotto, Mark A. Babizhayev

Publikováno v: American Journal of Therapeutics. 16:517-533

The antioxidant activity of L-carnosine (beta-alanyl-L-histidine, bioactivated in ocular tissues) versus N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine, ocular-targeted small dipeptide molecules) was studied in aqueous solution and in a lipid en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df58193adc893b29f2fca2b6ed6140d
https://doi.org/10.1097/mjt.0b013e318195e327

Mechanistic studies of amide bond scission during acidolytic deprotection of Pip containing peptide

Autor: Andrea Calderan, Alessio Osler, Andrea Guiotto, Paolo Ruzza, Chiara Rubini

Publikováno v: Journal of peptide science
14 (2008): 989–997. doi:10.1002/psc.1032
info:cnr-pdr/source/autori:Chiara Rubini; Alessio Osler; Andrea Calderan; Andrea Guiotto; Paolo Ruzza/titolo:Mechanistic studies of amide bond scission during acidolytic deprotection of Pip containing peptide/doi:10.1002%2Fpsc.1032/rivista:Journal of peptide science (Print)/anno:2008/pagina_da:989/pagina_a:997/intervallo_pagine:989–997/volume:14

Unusual TFA catalyzed cleavage reaction is reported for peptide containing pipecolic acid residues. Although the use of TFA under standard cleavage conditions is sufficiently mild to prevent degradation of the desired products, the amide bond between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19c7b69e8a838cd720059fe13d34bb5
https://doi.org/10.1002/psc.1032

Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micelles

Autor: Paolo Ruzza, Alessio Osler, Gianfranco Borin, Andrea Calderan, Andrea Guiotto

Publikováno v: Journal of peptide science
info:cnr-pdr/source/autori:Paolo Ruzza; Andrea Calderan; Andrea Guiotto; Alessio Osler; Gianfranco Borin/titolo:Tat cell-penetrating peptide has the characteristics of a poly(proline) II helix in aqueous solution and in SDS micelles./doi:10.1002%2Fpsc.558/rivista:Journal of peptide science (Print)/anno:2004/pagina_da:423/pagina_a:426/intervallo_pagine:423–426/volume:10

Tat cell-penetrating peptide (GRKKRRQRRRPPQG) is able to translocate and carry molecules across cell membranes. Using CD spectroscopy the conformation of this synthetic peptide was studied in aqueous and membrane-mimicking, micellar SDS solutions at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86a7d3ed1dcf1ae1c3702a69dadef53
https://doi.org/10.1002/psc.558

Synthesis, Characterization, and Preliminary in Vivo Tests of New Poly(ethylene glycol) Conjugates of the Antitumor Agent 10-Amino-7-ethylcamptothecin

Autor: Akinobu Kurita, Olivier Lavanchy, Norimasa Kaneda, Mirta Canevari, Francesco M. Veronese, Andrea Guiotto, Takeshi Yaegashi, Takeshi Matsuzaki, Piero Orsolini, Seigo Sawada, Christine Deuschel

Publikováno v: Journal of Medicinal Chemistry. 47:1280-1289

Despite the high antitumor activity of camptothecins, few derivatives have been developed and tested for human treatment of solid tumors, due to unpredictable toxicity mainly connected to their poor water solubility. We report the conjugation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071b0601ea367e5bba3066983254f8da
https://doi.org/10.1021/jm031072e

An Integrated Process for FDIR Design in Aerospace

Autor: Regis De Ferluc, Yuri Yushtein, Andrea Guiotto, Benjamin Bittner, Alessandro Cimatti, Marco Bozzano, Marco Gario

Publikováno v: Model-Based Safety and Assessment ISBN: 9783319122137
IMBSA

The correct operation of complex critical systems increasingly relies on the ability to detect and recover from faults. The design of Fault Detection, Isolation and Recovery (FDIR) sub-systems is highly challenging, due to the complexity of the under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f78d8d3bb15665cd456dff16d47f5eac
https://doi.org/10.1007/978-3-319-12214-4_7