Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrea Goya Grocin"'
Autor:
Thomas Lanyon-Hogg, Nattawadee Panyain, Edward W. Tate, Paulina Ciepla, Andrea Goya Grocin, Julia Morales-Sanfrutos, Wouter W. Kallemeijn
Publikováno v:
Nature Protocols. 16:5083-5122
Protein lipidation is challenging to analyze on the proteome level. This protocol describes metabolic incorporation of lipid probes and their capture via click chemistry, allowing in-gel fluorescence visualization or mass spectrometry analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aba4715661a25de6eefcd203521ac6f
https://doi.org/10.1038/s41596-021-00601-6
https://doi.org/10.1038/s41596-021-00601-6
Publikováno v:
Trends in Pharmacological Sciences. 42:870-882
For over three decades, methionine aminopeptidase 2 (MetAP2) has been a tentative drug target for the treatment of cancer, obesity, and autoimmune diseases. Currently, no MetAP2 inhibitors (MetAP2i) have reached the clinic yet, despite considerable i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898ba6df71575aa2c5311a6bd1685560
https://doi.org/10.1016/j.tips.2021.07.004
https://doi.org/10.1016/j.tips.2021.07.004
Autor:
Andrea Goya Grocin, Ravi Singh, Avinash R. Shenoy, Edward W. Tate, Cassandra R. Kennedy, Jennifer Ward, Tristan Kovačič
Publikováno v:
ACS Chemical Biology
Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fe72f8dd0512eaeb86f0fe57d59f6a
http://hdl.handle.net/10044/1/89757
http://hdl.handle.net/10044/1/89757
Autor:
Wouter W, Kallemeijn, Thomas, Lanyon-Hogg, Nattawadee, Panyain, Andrea, Goya Grocin, Paulina, Ciepla, Julia, Morales-Sanfrutos, Edward W, Tate
Publikováno v:
Nature protocols. 16(11)
Protein lipidation is one of the most widespread post-translational modifications (PTMs) found in nature, regulating protein function, structure and subcellular localization. Lipid transferases and their substrate proteins are also attracting increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea1c31e12d0e4098add4fdfcffb40339
https://pubmed.ncbi.nlm.nih.gov/34707257
https://pubmed.ncbi.nlm.nih.gov/34707257
Autor:
Marcus Conrad, Thibaut Vignane, José Pedro Friedmann Angeli, Valerie B. O'Donnell, Christina Scheel, Aloys Schepers, Markus Rehberg, Milene Costa da Silva, Almut Schulze, Werner Schmitz, Daniel A. White, Andrea Goya Grocin, Elena Panzilius, Katalin Buday, Andreas Kurz, Mami Sato, Sebastian Doll, Thamara Nishida Xavier da Silva, Grzegorz M. Popowicz, Ron Shah, Bettina Proneth, Derek A. Pratt, Maceler Aldrovandi, André Mourão, Michael Sattler, Edward W. Tate, Irina Ingold, Florencio Porto Freitas, Jonas Wanninger, Andrew Flatley, Vaishnavi Mohana, Markus Sauer
Publikováno v:
Nature 575, 693-698 (2019)
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85fd0dc662e86b7e39048146453fa89
http://hdl.handle.net/10044/1/75345
http://hdl.handle.net/10044/1/75345
Autor:
Wouter W, Kallemeijn, Gregor A, Lueg, Monica, Faronato, Kate, Hadavizadeh, Andrea, Goya Grocin, Ok-Ryul, Song, Michael, Howell, Dinis P, Calado, Edward W, Tate
Publikováno v:
Cell Chemical Biology
Summary On-target, cell-active chemical probes are of fundamental importance in chemical and cell biology, whereas poorly characterized probes often lead to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d951327fbdca4278eceb6c749397840d
https://pubmed.ncbi.nlm.nih.gov/31006618
https://pubmed.ncbi.nlm.nih.gov/31006618
Autor:
Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K. Miller, Edward W. Tate
Publikováno v:
Journal of the American Chemical Society. 144(49):22493-22504
Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of signaling cascades and cleavage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978dc13dd9d3a046a583b1c569777e60