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T cell activation plays a central role in inflammation, autoimmune diseases and cancer. Cancer immunotherapies, such as immune checkpoint inhibitor, bi-specific antibody, chimeric antigen receptor T (CAR T) cell, and adoptive tumor-infiltrating lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc589ca24f6a4145a99df48f9411774c
https://doi.org/10.5772/intechopen.97304
https://doi.org/10.5772/intechopen.97304
Publikováno v:
The Journal of Immunology. 202:131.7-131.7
Modulating TCR engagement and signaling using biologics, small molecules or genetic engineering is highly relevant to many therapeutic areas. TCR signal initiation is mediated by cytosolic tyrosine kinases, leading to signal amplification through a n