Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrea Gohlke"'
Autor:
Lucy V. Edwardes, Sarah J. Caswell, Mariacarmela Giurrandino, Xiang Zhai, Andrea Gohlke, Demetrios H. Kostomiris, Hannah K. Pollard, Alexander Pflug, Gregory R. Hamm, Kate V. Jervis, Paul N. Clarkson, Karl Syson
Publikováno v:
Biochemistry. 61:1974-1987
Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising bind
Autor:
Simon C. C. Lucas, Ulf Börjesson, Mark J. Bostock, John Cuff, Fredrik Edfeldt, Kevin J. Embrey, Per-Olof Eriksson, Andrea Gohlke, Anders Gunnarson, Michael Lainchbury, Alexander G. Milbradt, Rachel Moore, Philip B. Rawlins, Ian Sinclair, Christopher Stubbs, R. Ian Storer
Publikováno v:
RSC Med Chem
Fragment based drug discovery is a critical part of the lead generation toolbox and relies heavily on a readily available, high quality fragment library. Over years of use, the AstraZeneca fragment set had become partially depleted and instances of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446ddff84fa8641f08a20b101425dc2e
https://europepmc.org/articles/PMC9491351/
https://europepmc.org/articles/PMC9491351/
Autor:
Darerca Owen, Arooj Shafiq, Iolo J Squires, Samuel G Chamberlain, Helen R. Mott, Andrea Gohlke
Publikováno v:
Proc Natl Acad Sci U S A
RalA is a small GTPase and a member of the Ras family. This molecular switch is activated downstream of Ras and is widely implicated in tumor formation and growth. Previous work has shown that the ubiquitous Ca(2+)-sensor calmodulin (CaM) binds to sm
Autor:
Tamas Yelland, Esther Garcia, Charles Parry, Dominika Kowalczyk, Marta Wojnowska, Andrea Gohlke, Matja Zalar, Kenneth Cameron, Gillian Goodwin, Qing Yu, Peng-Cheng Zhu, Yasmin ElMaghloob, Angelo Pugliese, Lewis Archibald, Andrew Jamieson, Yong Xiang Chen, Duncan McArthur, Justin Bower, Shehab Ismail
RAS is a major anticancer drug target which requires membrane localization to activate downstream signal transduction. The direct inhibition of RAS has proven to be challenging. Here, we present a novel strategy for targeting RAS by stabilizing its i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d885e37325254d5946b7756fb441c13
https://eprints.gla.ac.uk/265430/1/265430.pdf
https://eprints.gla.ac.uk/265430/1/265430.pdf
Autor:
Nicolas Rabas, Payam A. Gammage, Sarah Palmer, Louise Mitchell, Shehab Ismail, Stephen W.G. Tait, Joel S. Riley, Jim C. Norman, Iain R. Macpherson, Andrea Gohlke, Leandro Lemgruber Soares
Publikováno v:
The Journal of Cell Biology
Rabas et al. describe a novel means of intercellular communication in which processes evoked to mitigate cytotoxicity in metabolically stressed cells can promote PINK1-dependent packaging of mitochondrial DNA into exosomes to evoke invasive behavior
Autor:
Stuart Francis, Daniel Croft, Alexander W. Schüttelkopf, Charles Parry, Angelo Pugliese, Ken Cameron, Sophie Claydon, Martin Drysdale, Claire Gardner, Andrea Gohlke, Gillian Goodwin, Christopher H. Gray, Jennifer Konczal, Laura McDonald, Mokdad Mezna, Andrew Pannifer, Nikki R. Paul, Laura Machesky, Heather McKinnon, Justin Bower
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in cancer cell metastasis by promoting cel
Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in cancer cell metastasis by promoting cel
Autor:
Jeff Coleman, Weiming Xu, Feng Li, Frederic Pincet, Sathish Ramakrishnan, James E. Rothman, Andrea Gohlke
Publikováno v:
Langmuir
Langmuir, 2018, 34 (20), pp.5849-5859. ⟨10.1021/acs.langmuir.8b00116⟩
Langmuir, American Chemical Society, 2018, 34 (20), pp.5849-5859. ⟨10.1021/acs.langmuir.8b00116⟩
Langmuir, 2018, 34 (20), pp.5849-5859. ⟨10.1021/acs.langmuir.8b00116⟩
Langmuir, American Chemical Society, 2018, 34 (20), pp.5849-5859. ⟨10.1021/acs.langmuir.8b00116⟩
International audience; In vivo membrane fusion primarily occurs between highly curved vesicles and planar membranes. A better understanding of fusion entails an accurate in vitro reproduction of the process. To date, supported bilayers have been com
Autor:
Kenneth S. Cameron, Jen Konczal, Andrea Gohlke, Gillian Goodwin, Justin Bower, C.G. Gray, Duncan McArthur, Alexander Schuettelkopf, Peter N. Brown, Angelo Pugliese, Martin J. Drysdale, Mokdad Mezna, Heather McKinnon
Publikováno v:
Biophysical Journal. 114:30a-31a
Autor:
Simone Möbitz, Rajesh Mishra, Christoph Jeworrek, Katrin Weise, Janine Seeliger, Suman Jha, Roland Winter, Daniel Sellin, Andrea Gohlke, Diana Radovan
Publikováno v:
Lipids and Cellular Membranes in Amyloid Diseases
Publikováno v:
ChemBioChem. 11:1280-1290
Type II diabetes mellitus (T2DM) is associated with beta-cell failure, which correlates with the formation of pancreatic islet amyloid deposits. The human islet amyloid polypeptide (hIAPP) is the major component of islet amyloid and undergoes structu