Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrea Gilg"'
Autor:
Mirja Harms, Monica M.W. Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H. Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2694-2708 (2021)
Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been identified as endogenous peptide antagonist and inverse
Externí odkaz:
https://doaj.org/article/877b759cf88f4e9a87e25611fe551bb2
Autor:
Pandian Sokkar, Mirja Harms, Christina Stürzel, Andrea Gilg, Gönül Kizilsavas, Martina Raasholm, Nico Preising, Manfred Wagner, Frank Kirchhoff, Ludger Ständker, Gilbert Weidinger, Benjamin Mayer, Jan Münch, Elsa Sanchez-Garcia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Combining molecular modeling and in vitro bioassays, Sokkar et al. provide an understanding of how EPI-X4, an endogenous peptide antagonist, interacts with its receptor CXCR4. With computational model, validated by mutagenesis studies, they design a
Externí odkaz:
https://doaj.org/article/f993d3d26776456ebe0fc89bf8e4a5df
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-5 (2021)
Abstract Background Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic proteases such as Cathep
Externí odkaz:
https://doaj.org/article/9af9818a35724edd8eab295ebfed8ff7
Autor:
Rüdiger Groß, Lívia Mesquita Dias Loiola, Leila Issmail, Nadja Uhlig, Valentina Eberlein, Carina Conzelmann, Lia‐Raluca Olari, Lena Rauch, Jan Lawrenz, Tatjana Weil, Janis A. Müller, Mateus Borba Cardoso, Andrea Gilg, Olivia Larsson, Urban Höglund, Sandra Axberg Pålsson, Anna Selch Tvilum, Kaja Borup Løvschall, Maria M. Kristensen, Anna‐Lena Spetz, Fortune Hontonnou, Marie Galloux, Thomas Grunwald, Alexander N. Zelikin, Jan Münch
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhi
Externí odkaz:
https://doaj.org/article/efb36e92da2449a5bac3fba657c93ca6
Autor:
Rüdiger Groß, Michelle Zanoni, Alina Seidel, Carina Conzelmann, Andrea Gilg, Daniela Krnavek, Sümeyye Erdemci-Evin, Benjamin Mayer, Markus Hoffmann, Stefan Pöhlmann, Weimin Liu, Beatrice H. Hahn, Alexandra Beil, Joris Kroschel, Bernd Jahrsdörfer, Hubert Schrezenmeier, Frank Kirchhoff, Jan Münch, Janis A. Müller
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103761- (2022)
Summary: Background: Heterologous COVID-19 vaccination regimens combining vector- and mRNA-based vaccines are already administered, but data on solicited adverse reactions, immunological responses and elicited protection are limited. Methods: To eval
Externí odkaz:
https://doaj.org/article/fcd33430a2d842e9bd5f10ff02995e22
Autor:
Armando Rodríguez-Alfonso, Astrid Heck, Yasser Bruno Ruiz-Blanco, Andrea Gilg, Ludger Ständker, Seah Ling Kuan, Tanja Weil, Elsa Sanchez-Garcia, Sebastian Wiese, Jan Münch, Mirja Harms
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15029 (2022)
Advanced derivatives of the Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) have shown therapeutic efficacy upon topical administration in animal models of asthma and dermatitis. Here, we studied the plasma stability of the EPI-X4 lead compounds WSC02
Externí odkaz:
https://doaj.org/article/ad67e52267f447f78fd0a53e34d6160f
Autor:
Lia-Raluca Olari, Richard Bauer, Marta Gil Miró, Verena Vogel, Laura Cortez Rayas, Rüdiger Groß, Andrea Gilg, Raphael Klevesath, Armando A. Rodríguez Alfonso, Kübra Kaygisiz, Ulrich Rupp, Pradeep Pant, Joel Mieres-Pérez, Lena Steppe, Ramona Schäffer, Lena Rauch-Wirth, Carina Conzelmann, Janis A. Müller, Fabian Zech, Fabian Gerbl, Jana Bleher, Nico Preising, Ludger Ständker, Sebastian Wiese, Dietmar R. Thal, Christian Haupt, Hendrik R. A. Jonker, Manfred Wagner, Elsa Sanchez-Garcia, Tanja Weil, Steffen Stenger, Marcus Fändrich, Jens von Einem, Clarissa Read, Paul Walther, Frank Kirchhoff, Barbara Spellerberg, Jan Münch
Publikováno v:
Cellular and Molecular Life Sciences
Antimicrobial peptides (AMPs) are major components of the innate immune defense. Accumulating evidence suggests that the antibacterial activity of many AMPs is dependent on the formation of amyloid-like fibrils. To identify novel fibril forming AMPs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbe8105cd8417e0164731a868a792e3
https://www.ncbi.nlm.nih.gov/pubmed/37198527
https://www.ncbi.nlm.nih.gov/pubmed/37198527
Autor:
Mirja Harms, Yasser Almeida-Hernández, Armando Rodríguez Alfonso, Monica Habib, Andrea Gilg, Dan Albers, Nermin Ahmed, Ashraf Abadi, Gilbert Weidinger, Ludger Ständker, Sebastian Wiese, Elsa Sanchez-Garcia, Jan Münch
EPI-X4 is a natural peptide antagonist of CXCR4, an established drug target in inflammatory diseases and cancer. Advanced derivatives of EPI-X4, such as EPI-X4 JM#21, have shown promising therapeutic effects in animal models of CXCR4-associated disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb796efe9dc5796c1ec299b7a987efd0
https://doi.org/10.22541/au.166733107.78559129/v1
https://doi.org/10.22541/au.166733107.78559129/v1
Autor:
Manfred Wagner, Gönül Kizilsavas, Christina M. Stürzel, Ludger Ständker, Gilbert Weidinger, Mirja Harms, Frank Kirchhoff, Elsa Sanchez-Garcia, Benjamin Mayer, Nico Preising, Andrea Gilg, Jan Münch, Pandian Sokkar, Martina Raasholm
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
EPI-X4, a 16-mer fragment of albumin, is a specific endogenous antagonist and inverse agonist of the CXC-motif-chemokine receptor 4 (CXCR4) and thus a key regulator of CXCR4 function. Accordingly, activity-optimized synthetic derivatives of EPI-X4 ar
Autor:
Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A. Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Rüdiger Groß, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärner, Steffen Stenger, Beate M. Kümmerer, Hendrik Streeck, Giorgio Fois, Manfred Frick, Peter Braubach, Anna-Lena Spetz, Thomas Grunwald, James Shorter, Elsa Sanchez-Garcia, Thomas Schrader, Jan Münch
Publikováno v:
JACS Au
The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Molecular tweezers are supramolecular agents that destabilize the envelope of viruses