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pro vyhledávání: '"Andrea Gierse"'
Autor:
Michael Stern, Grzegorz Podrygajlo, Gerd Bicker, Saime Tan, Million Adane Tegenge, Andrea Gierse, François Paquet-Durand
Publikováno v:
Cell and Tissue Research. 336:439-452
The well-characterized human teratocarcinoma line Ntera2 (NT2) can be differentiated into mature neurons. We have significantly shortened the time-consuming process for generating postmitotic neurons to approximately 4 weeks by introducing a differen
Publikováno v:
ALTEX. :16-21
Mouse models for colon cancer that harbor a germ line mutation in the tumor suppressor gene Adenomatous polyposis coli (Apc) exhibit a primary genetic defect that predisposes to a high incidence of adenomatous polyps in the small intestine rather tha
Publikováno v:
Brain Research. 1124:45-54
in vitro models are often used to investigate pathophysiological mechanisms of brain cell injury as they occur for instance during cerebral ischemia. To analyze the efficacy of potential neuroprotective compounds, cell physiological experiments were
Publikováno v:
Archives of toxicology. 88(1)
Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. Current DNT testing guidelines propose investigations in rodents, which require large numbers of animals. With regard to the "3Rs" (reduction, replaceme
Publikováno v:
ALTEX.
We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human mode