Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient

Autor: Andrea M. Smania, Sofía Feliziani, Lea Mette Madsen Sommer, Diego M. Moreno, Alejandro J. Vila, Laura G. Hedemann, Pablo E. Tomatis, Helle Krogh Johansen, Søren Molin, Rachel A. Hickman, Alejandro J. Moyano, Gina Dotta, Robert A. Bonomo, Andrea Georgina Albarracín Orio, C.A. Colque

Antibiotic resistance development has been studied using approaches that range from laboratory experimental evolution, surveillance and epidemiology, to clinical isolate sequencing. However, evolutionary trajectories depend on the environment in whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25275ab4e84355a615281f7b041bbe94
https://doi.org/10.1101/2021.05.14.444257

Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data

Autor: Ilaria Belluomo, Morgan Panitchpakdi, Aleksandr Smirnov, Mélissa Nothias-Esposito, Alexey V. Melnik, Gaud Dervilly, Rachel J. Dutton, Adolfo Amézquita, Vasilis Vasiliou, Zheng Zhang, Daniel Petras, Carrie D. Nicora, Audrey Poirier, James T. Morton, Ivan Laponogov, George B. Hanna, Sneha P. Couvillion, Biswapriya B. Misra, Robin Schmid, Wout Bittremieux, Raphaël Lugan, Brooke A. Anderson, Yann Guitton, Chris Callewaert, Kenneth L. Jones, Robert A. Quinn, Rob Knight, Larisa N. Kulikova, Itzhak Mizrahi, Erika M. Zink, Mabel Gonzalez, Sophie L. F. Doran, Rachel Gregor, Pauline Le Boulch, Kelem Gashu, Xiuxia Du, Michael M. Meijler, Kirill Veselkov, Chao Song, Elizabeth Humston-Fulmer, Noga Sikron Persi, Justin J. J. van der Hooft, Dennis Veselkov, Monica Guma, Kathleen Dorrestein, Saleh Alseekh, Roxana Coras, Chiara Carazzone, Thomas O. Metz, Aaron Fait, Andrea Georgina Albarracín Orio, Alexander A. Aksenov, Jose U. Scher, Andrea M. Smania, Bruno Le Bizec, Stav Eyal, Dinesh Kumar Barupal, Pieter C. Dorrestein, Alisdair R. Fernie, Reza Mirnezami, S. Prévost, Louis-Félix Nothias, Meagan C. Burnet, Viatcheslav B. Artaev, Mingxun Wang, Katherine N. Maloney, Julia Manasson, Madeleine Ernst, Roman S. Borisov, Amina Bouslimani

Publikováno v: Nat Biotechnol
Nature biotechnology
Aksenov, Alexander A., Laponogov, Ivan, Zhang, Zheng, Doran, Sophie L. F., Belluomo, Ilaria, Veselkov, Dennis, Bittremieux, Wout, Nothias, Louis Felix, Nothias-Esposito, Mélissa, Maloney, Katherine N., Misra, Biswapriya B., Melnik, Alexey V., Smirnov, Aleksandr, Du, Xiuxia, Jones, Kenneth L., Dorrestein, Kathleen, Panitchpakdi, Morgan, Ernst, Madeleine, van der Hooft, Justin J. J., Gonzalez, Mabel, Carazzone, Chiara, Amézquita, Adolfo, Callewaert, Chris, Morton, James T., Quinn, Robert A., Bouslimani, Amina, Orio, Andrea Albarracín, Petras, Daniel, Smania, Andrea M., Couvillion, Sneha P., Burnet, Meagan C., Nicora, Carrie D., Zink, Erika, Metz, Thomas O., Artaev, Viatcheslav, Humston-Fulmer, Elizabeth, Gregor, Rachel, Meijler, Michael M., Mizrahi, Itzhak, Eyal, Stav, Anderson, Brooke, Dutton, Rachel, Lugan, Raphaël, Boulch, Pauline Le, Guitton, Yann, Prevost, Stephanie, Poirier, Audrey, Dervilly, Gaud, Le Bizec, Bruno, Fait, Aaron, Persi, Noga Sikron, Song, Chao, Gashu, Kelem, Coras, Roxana, Guma, Monica, Manasson, Julia, Scher, Jose U., Barupal, Dinesh Kumar, Alseekh, Saleh, Fernie, Alisdair R., Mirnezami, Reza, Vasiliou, Vasilis, Schmid, Robin, Borisov, Roman S., Kulikova, Larisa N., Knight, Rob, Wang, Mingxun, Hanna, George B., Dorrestein, Pieter C. and Veselkov, Kirill (2021) Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data. Nature Biotechnology, 39 (2). ISSN 1087-0156
Nature Biotechnology
Nature Biotechnology, 39(2), 169-173
Nature Biotechnology, Nature Publishing Group, 2021, 39 (2), pp.169-173. ⟨10.1038/s41587-020-0700-3⟩
Nature Biotechnology 39 (2021) 2
Nature biotechnology, vol 39, iss 2

We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable the community to store, process, share, annotate, compare and perform molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ff89483759269c68c13571b23db181
http://hdl.handle.net/10044/1/84598

Fungal-bacterial interaction selects for quorum sensing mutants with increased production of natural antifungal compounds

Autor: Mingxun Wang, Alejandro J. Moyano, Romina Alín Tobares, Andrea Georgina Albarracín Orio, Daniel Petras, P. Sayago, Pieter C. Dorrestein, Andrea M. Smania, Florencia Juncosa, Alexander A. Aksenov

Publikováno v: Communications Biology
Communications biology, vol 3, iss 1
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)

Soil microorganisms coexist and interact showing antagonistic or mutualistic behaviors. Here, we show that an environmental strain of Bacillus subtilis undergoes heritable phenotypic variation upon interaction with the soil fungal pathogen Setophoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301bcc965836893833867588add085dd
https://pubmed.ncbi.nlm.nih.gov/33184402

Fungal-bacterial interaction selects for quorum sensing mutants and a metabolic shift towards the production of natural antifungal compounds

Autor: Mingxun Wang, Andrea Georgina Albarracín Orio, Romina Alín Tobares, P. Sayago, Florencia Juncosa, Pieter C. Dorrestein, Andrea M. Smania, Daniel Petras, Alexander A. Aksenov, Alejandro J. Moyano, Daniel Adrián Ducasse

Environmental species of bacteria and fungi coexist and interact showing antagonistic and mutualistic behaviors, mediated by exchange of small diffusible metabolites, driving microbial adaptation to complex communal lifestyles1. Here we show that a w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38be55d7dbbd61c185f82c7773aaf976

Compensatory Evolution of pbp Mutations Restores the Fitness Cost Imposed by β-Lactam Resistance in Streptococcus pneumoniae

Autor: Andrea Georgina Albarracín Orio, Germán E. Piñas, Melina B. Cian, José Echenique, Paulo R. Cortes

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 2, p e1002000 (2011)

The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the abs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f95cefd797505fb497dd4d7a428d03
http://europepmc.org/articles/PMC3040684