Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Andrea Gazzo"'
Autor:
Yingjie Zhu, Xin Pei, Ardijana Novaj, Jeremy Setton, Daniel Bronder, Fatemeh Derakhshan, Pier Selenica, Niamh McDermott, Mehmet Orman, Sarina Plum, Shyamal Subramanyan, Sara H. Braverman, Biko McMillan, Sonali Sinha, Jennifer Ma, Andrea Gazzo, Atif Khan, Samuel Bakhoum, Simon N. Powell, Jorge S. Reis-Filho, Nadeem Riaz
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cell
Externí odkaz:
https://doaj.org/article/a99e307f304a411b854e096a6e780f20
Autor:
Jing Yu, Edaise M. da Silva, Hae-Sun La, Beth Z. Clark, Jeffrey L. Fine, Gloria J. Carter, Tatiana M. Villatoro, T. Rinda Soong, Adrian V. Lee, Steffi Oesterreich, Thais Basili, Juan Blanco-Heredia, Pier Selenica, Qiqi Ye, Arnaud Da Cruz Paula, Higinio Dopeso, Andrea Gazzo, Antonio Marra, Fresia Pareja, Jorge S. Reis-Filho, Rohit Bhargava
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract This study describes “lobular-like invasive mammary carcinomas” (LLIMCas), a group of low- to intermediate-grade invasive mammary carcinomas with discohesive, diffusely infiltrative cells showing retained circumferential membranous immun
Externí odkaz:
https://doaj.org/article/a2ffe8ff28f6494d9753ae713d6f5f51
Autor:
Timothy M D'Alfonso, Fresia Pareja, Arnaud Da Cruz Paula, Mahsa Vahdatinia, Andrea Gazzo, Lorenzo Ferrando, Edaise M da Silva, Esther Cheng, Lisa Sclafani, Sarat Chandarlapaty, Hong Zhang, Syed A Hoda, Hannah Y Wen, Edi Brogi, Britta Weigelt, Jorge S Reis‐Filho
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 2, Pp 113-120 (2021)
Abstract Juvenile papillomatosis (JP) of the breast is a rare benign mass‐forming lesion occurring in young women, which is histologically characterized by a constellation of proliferative changes and large cysts, giving it the gross appearance of
Externí odkaz:
https://doaj.org/article/f30c2cca903d4d859d3f9b547aded646
Abstract HER2-07: HER2-07 Genomic Characterization of Primary and Metastatic HER2-low Breast Cancers
Autor:
Antonio Marra, Anton Safonov, Joshua Drago, Emanuela Ferraro, Pier Selenica, Andrea Gazzo, Giuseppe Curigliano, Shanu Modi, Pedram Razavi, Jorge Reis-Filho, Sarat Chandarlapaty
Publikováno v:
Cancer Research. 83:HER2-07
Background: Varying levels of HER2 expression without ERBB2 gene amplification can be detected by immunohistochemistry (IHC) in approximately 60% of all invasive breast cancers (BCs). HER2-low-expressing BCs have recently been shown to respond to nov
Autor:
Fu-Tien Liao, Tia Gordon, Chia Chia Liu, Pier Selenica, Yingjie Zhu, Juber Patel, Sarmistha Nanda, Lanfang Qin, Xiaoyong Fu, Andrea Gazzo, Antonio Marra, Juan Blanco-Heredia, Britta Weigelt, Jorge Reis-Filho, C. Kent Osborne, Mothaffar Rimawi, Rachel Schiff, Jamunarani Veeraraghavan
Publikováno v:
Cancer Research. 83:P1-13
Background: The HER2-specific tyrosine kinase inhibitor (TKI) tucatinib (Tuca) recently approved for advanced HER2+ breast cancer is making a move towards the early setting. Given its growing use, resistance is inevitable, as observed in the HER2CLIM
Autor:
Jorge S. Reis-Filho, Britta Weigelt, James B. Hicks, Hannah Y. Wen, Lorenzo Ferrando, Anthe A. Stylianou, Mahsa Vahdatinia, Edaise M. da Silva, Andrea Gazzo, Felipe C. Geyer, Rui Bi, Pier Selenica, Arnaud Da Cruz Paula, Ju Youn Lee, David N. Brown, Fresia Pareja
Purpose:Ductal carcinoma in situ (DCIS) is a nonobligate precursor of invasive breast cancer. Here, we sought to investigate the level of intralesion genetic heterogeneity in DCIS and the patterns of clonal architecture changes in the progression fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe12d987140eaa56229893e2af04cdb
https://doi.org/10.1158/1078-0432.c.6529074
https://doi.org/10.1158/1078-0432.c.6529074
Autor:
Jorge S. Reis-Filho, Britta Weigelt, James B. Hicks, Hannah Y. Wen, Lorenzo Ferrando, Anthe A. Stylianou, Mahsa Vahdatinia, Edaise M. da Silva, Andrea Gazzo, Felipe C. Geyer, Rui Bi, Pier Selenica, Arnaud Da Cruz Paula, Ju Youn Lee, David N. Brown, Fresia Pareja
Supplementary Figure S3 shows the copy number profiles of ductal carcinomas in situ (DCIS) and invasive ductal carcinomas of no special type (IDC-NST), and frequency of most commonly mutated genes in DCIS, compared to luminal B IDC-NSTs, and accordin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7554451b110ed63f8fab49d02962ad65
https://doi.org/10.1158/1078-0432.22475418.v1
https://doi.org/10.1158/1078-0432.22475418.v1
Autor:
Jorge S. Reis-Filho, Britta Weigelt, James B. Hicks, Hannah Y. Wen, Lorenzo Ferrando, Anthe A. Stylianou, Mahsa Vahdatinia, Edaise M. da Silva, Andrea Gazzo, Felipe C. Geyer, Rui Bi, Pier Selenica, Arnaud Da Cruz Paula, Ju Youn Lee, David N. Brown, Fresia Pareja
Supplementary Table S2 shows the non-synonymous somatic mutations identified in synchronous DCIS and IDC-NSTs subjected to whole-exome sequencing or MSK-IMPACT targeted massively parallel sequencing and/or targeted amplicon sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1140836dc14837abd131bedb952389cc
https://doi.org/10.1158/1078-0432.22475403
https://doi.org/10.1158/1078-0432.22475403
Autor:
Antonio Marra, Andrea Gazzo, Pier Selenica, Xin Pei, Avantika Gupta, Fresia Pareja, Giuseppe Curigliano, Reuben Harris, Nadeem Riaz, Jorge S. Reis-Filho, Sarat Chandarlapaty
Publikováno v:
Cancer Research. 82:PD1-06
Background: Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) enzymes drive genomic instability in breast cancer (BC) characterized by specific single base substitution mutation signatures (COSMIC S2 and S13). Computational alg
Autor:
Jorge S. Reis-Filho, Pamela Drullinsky, Maksym Misyura, Liying Zhang, Vikas Rai, Edaise M da Silva, Britta Weigelt, Jinru Shia, Hong Zhang, Edi Brogi, Joshua Z. Drago, Mark E. Robson, Antonio Marra, Christopher J Schwartz, Pedram Razavi, Hannah Y Wen, Andrea Gazzo, Diana Mandelker, Pier Selenica, Timothy M. D'Alfonso, Fresia Pareja
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 2
Purpose: Lynch syndrome is defined by germline pathogenic mutations involving DNA mismatch repair (MMR) genes and linked with the development of MMR-deficient colon and endometrial cancers. Whether breast cancers developing in the context of Lynch sy