Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Andrea Gamir-Morralla"'
1
Akademický článek
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Autor: Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián-Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero, Teresa Iglesias
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its act
Externí odkaz: https://doaj.org/article/cb128c406cd844578138ccf113906e62
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2
Akademický článek
Author Correction: Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Autor: Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián-Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero, Teresa Iglesias
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the spelling of the author Álvaro Sebastián-Serrano, which was incorrectly given as Álvaro Sebastián Serrano. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz: https://doaj.org/article/60592296656942d89b1afe3ede1df2f3
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3
Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes
Autor: Andrea Gamir-Morralla, Teresa Iglesias, Rafael Luján, Naoki Mochizuki, Celia López-Menéndez, Ana Simón-García, Julia Pose-Utrilla, Margarita Díaz-Guerra
Publikováno v: Cell Death and Disease, Vol 10, Iss 7, Pp 1-19 (2019)
RUIdeRA. Repositorio Institucional de la UCLM
instname
Cell Death & Disease
Digital.CSIC. Repositorio Institucional del CSIC
© The Author(s) 2019.
Excitotoxic neuronal death induced by high concentrations of glutamate is a pathological event common to multiple acute or chronic neurodegenerative diseases. Excitotoxicity is mediated through overactivation of the N-Meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c802a5338de72edb649dc4a1023bb3c
http://link.springer.com/article/10.1038/s41419-019-1766-z
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4
Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a
Autor: Andrea, Gamir-Morralla, Sandra, Sacristán, Miguel, Medina, Teresa, Iglesias
Publikováno v: Journal of Alzheimer's Disease Reports
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to study lifespan and aging, protein aggregation, and neurodegeneration, as well as to carry out drug screenings. The C. elegans strain aex-3/T337 expresses human pathogeni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbfd5185077120556cceef55b7e3ae30
https://pubmed.ncbi.nlm.nih.gov/30842997
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5
Effects of thioflavin T and GSK-3 inhibition on lifespan and motility in a Caenorhabditis elegans model of tauopathy
Autor: Miguel Medina, Andrea Gamir-Morralla, Teresa Iglesias, Sandra Sacristán
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to study lifespan and aging, protein aggregation, and neurodegeneration, as well as to carry out drug screenings. The C. elegans strain aex-3/T337 expresses human pathogeni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9c9d63938d5c899e04efaf29932d97
http://hdl.handle.net/10261/219271
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6
Kidins220 Correlates with Tau in Alzheimer’s Disease Brain and Cerebrospinal Fluid
Autor: Isidro Ferrer, Andrea Gamir-Morralla, Teresa Iglesias, Daniel Alcolea, A. Lleo, Juan Fortea, Olivia Belbin
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
JOURNAL OF ALZHEIMERS DISEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrosp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9b866f40bde72ec74e95ddb42ca4de
https://doi.org/10.3233/jad-160639
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8
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Autor: Andrea Gamir-Morralla, Christofer Ireson, Abraham Martín, Teresa Iglesias, Mª José Pérez-Álvarez, Isidro Ferrer, Miguel R. Campanero, Noelia S. de León-Reyes, Jerónimo Jurado-Arjona, Lucía García-Guerra, Félix Hernández, Ana del Puerto, Julia Pose-Utrilla, Mónica García-Gallo, Marina Lasa, Jesús Avila, Jens Fielitz, Leonor Kremer, Álvaro Sebastián-Serrano
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03b042cd30d28a39a087ea507dc78a7
https://zenodo.org/record/1153781
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9
A novel neuroprotection target with distinct regulation in stroke and Alzheimer’s disease
Autor: Andrea Gamir-Morralla, Teresa Iglesias, Celia López-Menéndez, Miguel Medina
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Stroke and Alzheimer’s disease (AD) share a common mechanism of neuronal death known as excitotoxicity. Therapeutic approaches blocking excitotoxic responses, with agents, such as the NMDA receptor antagonist memantine, inhibitors of the protease c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1b07e5c89ee91aa5ddf04f90132936
http://hdl.handle.net/10261/191197
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10
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance
Autor: Jerónimo Jurado-Arjona, Félix Hernández, Teresa Iglesias, Alonso M. Higuero, Jesús Avila, Margarita Díaz-Guerra, Miguel R. Campanero, Isidro Ferrer, Celia López-Menéndez, Andrea Gamir-Morralla
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Failures in neurotrophic support and signalling play key roles in Alzheimer's disease (AD) pathogenesis. We previously demonstrated that downregulation of the neurotrophin effector Kinase D interacting substrate (Kidins220) by excitotoxicity and cere
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39264c0ddd710f3fce2593d0cd8f5799
https://doi.org/10.1093/hmg/dds446
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