Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Andrea Gaedigk"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundCYP2D6 testing is increasingly used to guide drug therapy and thus, reliable methods are needed to test this complex and polymorphic gene locus. A particular challenge arises from the detection and interpretation of structural variants (SVs
Externí odkaz:
https://doaj.org/article/af9f484293b1485e8c106e6b13488163
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/5b86d78c843c43108c539809f2da76de
Autor:
Kathryn E. Kyler, Andrea Gaedigk, Susan Abdel‐Rahman, Vincent S. Staggs, Robin E. Pearce, Paul Toren, J. Steven Leeder, Valentina Shakhnovich
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype (CYP2C:TG) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has been proposed to be associated with increased CY
Externí odkaz:
https://doaj.org/article/8b9ea8205bc84afc9605d87167a8d7ec
Autor:
Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, Andrea Gaedigk
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract The DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefor
Externí odkaz:
https://doaj.org/article/5ba0596362e44f6ea49932ac67879e47
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 2, Pp 269-278 (2023)
Abstract The goal of this study was to determine whether CYP2D6 metabolizer status within the ondansetron‐treated pediatric tonsillectomy population is associated with risk of postoperative nausea and vomiting (PONV) in the post‐anesthesia care u
Externí odkaz:
https://doaj.org/article/712ce31a96b04aaeb38118a38cf6f444
Autor:
Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney Nolte, Kim Gibson, J. Steven Leeder, Tamorah Lewis
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 1, Pp 110-121 (2023)
Abstract Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care un
Externí odkaz:
https://doaj.org/article/e4398aef648645be846a29c340059eaf
Autor:
Jonathan B. Wagner, Susan Abdel-Rahman, Geetha Raghuveer, Andrea Gaedigk, Erin C. Boone, Roger Gaedigk, Vincent S. Staggs, Gregory A. Reed, Na Zhang, J. Steven Leeder
Publikováno v:
Genes, Vol 15, Iss 1, p 99 (2024)
This clinical study examined the influence of SLCO1B1 c.521T>C (rs4149056) on plasma atorvastatin concentrations in pediatric hypercholesterolemia. The participants (8–21 years), including heterozygous (c.521T/C, n = 13), homozygous (c.521C/C, n =
Externí odkaz:
https://doaj.org/article/198ec000aedc4f7db50ff50e1be3f3f2
Autor:
Amy J. Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David B. Gregornik, Keith Brown, Ulrich Broeckel, Gunter Scharer
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Complex regions in the human genome such as repeat motifs, pseudogenes and structural (SVs) and copy number variations (CNVs) present ongoing challenges to accurate genetic analysis, particularly for short-read Next-Generation-Sequencing (NGS) techno
Externí odkaz:
https://doaj.org/article/6fa0fec7755a47f89cb10893ddece312
Autor:
J. Steven Leeder, Andrea Gaedigk, Krista J. Wright, Vincent S. Staggs, Sarah E. Soden, Yvonne S. Lin, Robin E. Pearce
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2514-2527 (2022)
Abstract CYP2D6 substrates are among the most highly prescribed medications in teenagers and also commonly associated with serious adverse events. To investigate the relative contributions of genetic variation, growth, and development on CYP2D6 activ
Externí odkaz:
https://doaj.org/article/db29e85ec5c14e4484a7143f40dac3f8
Autor:
Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, Sara L. Van Driest
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1787-1795 (2022)
Abstract Propafenone is an antiarrhythmic drug metabolized primarily by cytochrome P450 2D6 (CYP2D6). In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking. Subjects were t
Externí odkaz:
https://doaj.org/article/6026c7e303044f3babf4a37c9394b561