Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Andrea G. Hohmann"'
Autor:
Kelsey G. Guenther, Xiaoyan Lin, Zhili Xu, Alexandros Makriyannis, Julian Romero, Cecilia J. Hillard, Ken Mackie, Andrea G. Hohmann
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116879- (2024)
Cannabinoid CB2 agonists show therapeutic efficacy without unwanted CB1-mediated side effects. The G protein-biased CB2 receptor agonist LY2828360 attenuates the maintenance of chemotherapy-induced neuropathic nociception in male mice and blocks deve
Externí odkaz:
https://doaj.org/article/d630173bab094f5b85199ead4b49f232
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Publikováno v:
Bioactive Materials, Vol 22, Iss , Pp 482-490 (2023)
pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly und
Externí odkaz:
https://doaj.org/article/333e4ae18a1e433886dd356eb43bf637
Autor:
Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann, Craig F. Ferris
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? We hypothesized that C
Externí odkaz:
https://doaj.org/article/f485f7eb3333468a9b1e8597a6b74aad
Autor:
Ai-Ling Li, Jonathon D. Crystal, Yvonne Y. Lai, Tammy J. Sajdyk, Jamie L. Renbarger, Andrea G. Hohmann
Publikováno v:
Neurobiology of Pain, Vol 10, Iss , Pp 100077- (2021)
Childhood acute lymphoblastic leukemia (ALL) is a significant clinical problem that can be effectively treated with vincristine, a vinca alkaloid-based chemotherapeutic agent. However, nearly all children receiving vincristine treatment develop vincr
Externí odkaz:
https://doaj.org/article/29e345b034294985b0e4b26dc6a669bd
Autor:
Maryam Omran, Elizabeth K. Belcher, Nimish A. Mohile, Shelli R. Kesler, Michelle C. Janelsins, Andrea G. Hohmann, Ian R. Kleckner
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-limiting side effect of many chemotherapy regimens yet has limited treatments due to incomplete knowledge of its pathophysiology. Research on the pathophysiology of
Externí odkaz:
https://doaj.org/article/c6727e0e42584ad6a16350f409dfb878
Autor:
Richard A. Slivicki, Vishakh Iyer, Sonali S. Mali, Sumanta Garai, Ganesh A. Thakur, Jonathon D. Crystal, Andrea G. Hohmann
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in a number of unwanted side-effects including incomplete efficacy, constipation, physical depen
Externí odkaz:
https://doaj.org/article/fdca151317774c32b3e7e90819757de9
Autor:
Lawrence M. Carey, Tannia Gutierrez, Liting Deng, Wan-Hung Lee, Ken Mackie, Andrea G. Hohmann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The G-protein coupled receptor GPR55 has been postulated to serve as a novel cannabinoid receptor. A previous report indicated that GPR55 knockout mice fail to develop mechanical hyperalgesia, suggesting a pro-nociceptive role for GPR55 in t
Externí odkaz:
https://doaj.org/article/4b5b7f6227954b9f86d12bdebdc63a59
Autor:
Nadia Soliman, Andrea G. Hohmann, Simon Haroutounian, Kimberley Wever, Andrew S.C. Rice, David P. Finn
Publikováno v:
PAIN Reports, Vol 4, Iss 4, p e766 (2019)
Abstract. Introduction:. The International Association for the Study of Pain has established a global task force to comprehensively investigate the use of cannabinoids and cannabis-based medicines for pain management. This systematic review, the firs
Externí odkaz:
https://doaj.org/article/3197cc164dc246189154ae96c08a1f9c
Autor:
Lawrence M. Carey, Ken Mackie, Zhili Xu, Xiaoyan Lin, Phillip J. Albrecht, Cecilia J. Hillard, Marilyn Dockum, Alexandros Makriyannis, George Houk, Andrea G. Hohmann, Frank L. Rice, Julián Romero, Elizabeth Ruggiero
Publikováno v:
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
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CB2 cannabinoid receptors (CB2) are a promising therapeutic target that lacks unwanted side effects of CB1 activation. However, the cell types expressing CB2 that mediate these effects remain poorly understood. We used transgenic mice with CB2 promot