Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Andrea G. Cochran"'
Autor:
Mariano Oppikofer, Meredith Sagolla, Benjamin Haley, Hui-Min Zhang, Sarah K. Kummerfeld, Jawahar Sudhamsu, E. Megan Flynn, Tianyi Bai, Jennifer Zhang, Claudio Ciferri, Andrea G. Cochran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromod
Externí odkaz:
https://doaj.org/article/ba2fcffc416342099321e94a0269cffd
Autor:
Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 65(16)
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent an
Publikováno v:
Nature Reviews Drug Discovery. 18:609-628
Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader' modules found in proteins with varied functions, were highly tractable small-molecule targets. This is an unusual property for protein-protein or protein-peptide interacti
Autor:
Yutian Gan, Peter Liu, Tianyi Bai, Claudio Ciferri, Mariano Oppikofer, Benjamin Haley, Andrea G. Cochran, Wendy Sandoval
Publikováno v:
EMBO reports. 18:1697-1706
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two highly similar ATPases. However, we find that each endogenously expressed ATPase co-purifies w
Autor:
Shumei Wang, Peter Sandy, Christopher G. Nasveschuk, Terry Crawford, Brian K. Albrecht, Andrea G. Cochran, Steffan Vartanian, Hon-Ren Huang, Vickie Tsui, David Stokoe, Steve Bellon, Yong Tang, E. Megan Flynn, Jian Wang, James R. Kiefer, Jeremy Murray, F. Anthony Romero, Laura Zawadzke, Michael C. Hewitt, Martin Duplessis, Alexander M. Taylor, Eneida Pardo, Alexandre Côté, Steven Magnuson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3534-3541
Bromodomain-containing protein 9 (BRD9), an epigenetic "reader" of acetylated lysines on post-translationally modified histone proteins, is upregulated in multiple cancer cell lines. To assess the functional role of BRD9 in cancer cell lines, we iden
Autor:
Arianne Neiss, Martin Duplessis, Hariharan Jayaram, Shumei Wang, F. Anthony Romero, Christopher G. Nasveschuk, Daniel J. Burdick, James E. Audia, Terry Crawford, Steve Bellon, Hon-Ren Huang, Zhaowu Xu, Yongyun Wang, Ying Jiang, Michael C. Hewitt, Jeremy Murray, Andrea G. Cochran, Peter Sandy, Yong Tang, Brian K. Albrecht, E. Megan Flynn, James R. Kiefer, Archana Bommi-Reddy, Jian Wang, Laura Zawadzke, Shivangi Joshi, Vickie Tsui, Xiaoqin Zhu, Alexander M. Taylor, Robert J. Sims, Eneida Pardo, Alexandre Côté, Steven Magnuson, Richard T. Cummings
Publikováno v:
ACS Medicinal Chemistry Letters. 8:737-741
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region can
Autor:
Shumei Wang, Vickie Tsui, Terry D. Crawford, James E. Audia, Daniel J. Burdick, Maureen H. Beresini, Alexandre Côté, Richard Cummings, Martin Duplessis, E. Megan Flynn, Michael C. Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, Jeremy Murray, Christopher G. Nasveschuk, Eneida Pardo, Florence Poy, F. Anthony Romero, Yong Tang, Alexander M. Taylor, Jian Wang, Zhaowu Xu, Laura E. Zawadzke, Xiaoyu Zhu, Brian K. Albrecht, Steven R. Magnuson, Steve Bellon, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 61(20)
The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a
Autor:
Jennifer Zhang, Sarah K. Kummerfeld, Mariano Oppikofer, Benjamin Haley, Andrea G. Cochran, Jawahar Sudhamsu, E. Megan Flynn, Meredith Sagolla, Tianyi Bai, Claudio Ciferri, Hui-Min Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage. However, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BA
Autor:
Kim Newton, Jennie R. Lill, Mark Vasser, Zora Modrusan, Jason DeVoss, Rajkumar Noubade, Oscar W. Huang, Donald S. Kirkpatrick, Vishva M. Dixit, Qui T. Phung, Joshua D. Webster, Andrea G. Cochran, Benjamin Fauber, Justin Lesch, Rongze Lu, Lauri Diehl, Xiaoting Wang, Sascha Rutz, Nobuhiko Kayagaki, Celine Eidenschenk, Wenjun Ouyang
Publikováno v:
Nature. 518:417-421
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases. The differentiation of TH17 cells is regulated by transcription factors such as RORγt, bu
Autor:
Jonathan Maher, F. Anthony Romero, Samir Kharbanda, Mark Merchant, Ivana Yen, Yingjie Li, Edna F. Choo, Jiangpeng Liao, Xiaocang Wei, Kwong Wah Lai, Karen E. Gascoigne, Richard D. Cummings, Hariharan Jayaram, Thomas Hunsaker, Steven F. Bellon, Jian Wang, Cameron L. Noland, Brian K. Albrecht, Ying Jiang, Jeremy Murray, Susan Kaufman, Kerry L. Spillane, Florence Poy, Zhaowu Xu, Fei Wang, James R. Kiefer, Laura Zawadzke, Zhongguo Chen, Alexander M. Taylor, Andrew R. Conery, Xiaoyu Zhu, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Andrea G. Cochran, Vickie Tsui, Steven Magnuson, Terry Crawford, Maureen Beresini, Emily Chan, Kevin X. Chen, Gladys de Leon Boenig, Justin Ly, Tracy Kleinheinz, Zhongya Xu
Publikováno v:
Journal of medicinal chemistry. 59(23)
The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target of much recent interest in cancer and immune system regulation. A co-crystal structure of a ligand-efficient screening hit and the CBP bromodomain guided i