Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Andrea G Hohmann"'
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147620 (2016)
Nicotinamide mononucleotide adenylyl transferases (NMNATs) are essential neuronal maintenance factors postulated to preserve neuronal function and protect against axonal degeneration in various neurodegenerative disease states. We used in vitro and i
Externí odkaz:
https://doaj.org/article/4ece86973bbd4dea92ea6573e3a677ec
Autor:
Kelsey G. Guenther, Xiaoyan Lin, Zhili Xu, Alexandros Makriyannis, Julian Romero, Cecilia J. Hillard, Ken Mackie, Andrea G. Hohmann
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116879- (2024)
Cannabinoid CB2 agonists show therapeutic efficacy without unwanted CB1-mediated side effects. The G protein-biased CB2 receptor agonist LY2828360 attenuates the maintenance of chemotherapy-induced neuropathic nociception in male mice and blocks deve
Externí odkaz:
https://doaj.org/article/d630173bab094f5b85199ead4b49f232
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Publikováno v:
Bioactive Materials, Vol 22, Iss , Pp 482-490 (2023)
pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly und
Externí odkaz:
https://doaj.org/article/333e4ae18a1e433886dd356eb43bf637
Autor:
Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann, Craig F. Ferris
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? We hypothesized that C
Externí odkaz:
https://doaj.org/article/f485f7eb3333468a9b1e8597a6b74aad
Autor:
Maryam Omran, Elizabeth K. Belcher, Nimish A. Mohile, Shelli R. Kesler, Michelle C. Janelsins, Andrea G. Hohmann, Ian R. Kleckner
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-limiting side effect of many chemotherapy regimens yet has limited treatments due to incomplete knowledge of its pathophysiology. Research on the pathophysiology of
Externí odkaz:
https://doaj.org/article/c6727e0e42584ad6a16350f409dfb878
Autor:
Lawrence M. Carey, Ken Mackie, Zhili Xu, Xiaoyan Lin, Phillip J. Albrecht, Cecilia J. Hillard, Marilyn Dockum, Alexandros Makriyannis, George Houk, Andrea G. Hohmann, Frank L. Rice, Julián Romero, Elizabeth Ruggiero
Publikováno v:
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
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CB2 cannabinoid receptors (CB2) are a promising therapeutic target that lacks unwanted side effects of CB1 activation. However, the cell types expressing CB2 that mediate these effects remain poorly understood. We used transgenic mice with CB2 promot
Autor:
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Opioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced hyperalgesia are significantly understudied, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7fec096bd5d5e09dd522604133508c
https://doi.org/10.1101/2022.10.03.510710
https://doi.org/10.1101/2022.10.03.510710
Autor:
Lawrence M. Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G. Hohmann
Publikováno v:
Pharmacological research. 187
Painful peripheral neuropathy is a common neurological complication associated with human immunodeficiency virus (HIV) infection and anti-retroviral therapy. We characterized the impact of two CB2 cannabinoid agonists (AM1710 and LY2828360 - ligands
Autor:
Idaira Oliva, Shahin A. Saberi, Claudia Rangel‐Barajas, Vishakh Iyer, Kendra D. Bunner, Yvonne Y. Lai, Pushkar M. Kulkarni, Sumanta Garai, Ganesh A. Thakur, Jonathon D. Crystal, George V. Rebec, Andrea G. Hohmann
Publikováno v:
Addiction Biology. 27
Glutamate signalling through the N-methyl-d-aspartate receptor (NMDAR) activates the enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (NO). We hypothesized that disruption of the protein-protein interaction