Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE

Autor: Gretel Buchwald, Jorge E. Galán, Alfred Wittinghofer, Klaus Scheffzek, Wolf-Dietrich Hardt, Andrea Friebel

Publikováno v: The EMBO Journal. 21:3286-3295

The bacterial enteropathogen Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f196bbf62a958b0caecfa4638a30595b
https://doi.org/10.1093/emboj/cdf329

SopE and SopE2 from Salmonella typhimurium Activate Different Sets of RhoGTPases of the Host Cell

Autor: Kristin Ehrbar, Werner Machleidt, Andrea Friebel, Martin Aepfelbacher, Heiko Ilchmann, Wolf-Dietrich Hardt

Publikováno v: Journal of Biological Chemistry. 276:34035-34040

The bacterial enteropathogen Salmonella typhimurium employs a specialized type III secretion system to inject toxins into host cells, which trigger signaling cascades leading to cell death in macrophages, secretion of pro-inflammatory cytokines, or r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852754c9ca70ffd4cad79eb21ff55e4e
https://doi.org/10.1074/jbc.m100609200

A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity

Autor: Philip J. Brown, Michael W. Wood, Wolf-Dietrich Hardt, Lowrie A. Taylor, Andrea Friebel, Mark P. Stevens, Edouard E. Galyov

Publikováno v: Stevens, M P, Friebel, A, Taylor, L A, Wood, M W, Brown, P J, Hardt, W D & Galyov, E E 2003, ' A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity ', Journal of Bacteriology, vol. 185, no. 16, pp. 4992-4996 . https://doi.org/10.1128/JB.185.16.4992-4996.2003

We report the characterization of BopE, a type III secreted protein that is encoded adjacent to the Burkholderia pseudomallei bsa locus and is homologous to Salmonella enterica SopE/SopE2. Inactivation of bopE impaired bacterial entry into HeLa cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534da1a990cc12f5f9c71ef22d2f59b1
http://ora.ox.ac.uk/objects/uuid:0890cd2e-7dc8-4d4e-979e-ef603c6cea24

Characterization of effector proteins translocated via the SPI1 type III secretion system of Salmonella typhimurium

Autor: Kristin Ehrbar, Wolf-Dietrich Hardt, Silke Stender, Susanne Mirold, Andrea Friebel

Publikováno v: International journal of medical microbiology : IJMM. 291(6-7)

Salmonella spp. employ a conserved type III secretion system encoded within the pathogenicity island 1 (SPI1; centisome 63) to translocate effector proteins into the host cytosol. The translocated effector proteins trigger diverse responses including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccb1f56bfc84f409d9cd53333b5548a
https://pubmed.ncbi.nlm.nih.gov/11890547