Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Andrea Ebert"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 8, Iss , Pp 100269- (2024)
MDCK/Caco-2 assays serve as essential in vitro tools for evaluating membrane permeability and active transport, especially mediated by P-glycoprotein (P-gp). Despite their utility, challenges remain in quantifying active transport and using the efflu
Externí odkaz:
https://doaj.org/article/54e3945b07424f23ac3a6324ac9b6296
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 132 (2024)
The efflux ratio (ER), determined by Caco-2/MDCK assays, is the standard in vitro metric to establish qualitatively whether a compound is a substrate of an efflux transporter. However, others have also enabled the utilisation of this metric quantitat
Externí odkaz:
https://doaj.org/article/aad6f2d8c1d947fd91a5720ae14b21f5
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-10 (2021)
Deep neural networks are potent tools for computational chemistry, but experimental feed data can limit their reach. Here the authors develop deep neural network data augmentation models to predict octanol–water partition coefficients (log P) of a
Externí odkaz:
https://doaj.org/article/9d61fbcad06746a6a19e36cf2342853f
Autor:
Thomas Barta, Walter Sandtner, Johann Wachlmayr, Christof Hannesschlaeger, Andrea Ebert, Armin Speletz, Andreas Horner
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions
Externí odkaz:
https://doaj.org/article/d26860ce12304738a2f4f5b20bbc02ca
Publikováno v:
Environmental Science and Pollution Research. 30:50257-50268
Bioconcentration tests using the freshwater amphipod Hyalella azteca as an alternative to conventional fish tests have recently received much attention. An appropriate computational model of H. azteca could help in understanding the mechanisms behind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137c98ebd8f54da2eff9948b50f36263
https://doi.org/10.1007/s11356-023-25827-7
https://doi.org/10.1007/s11356-023-25827-7
Autor:
Andrea Ebert, Kai-Uwe Goss
Publikováno v:
Toxicological Sciences. 185:208-219
Protonophoric uncoupling of phosphorylation is an important factor when assessing chemicals for their toxicity, and has recently moved into focus in pharmaceutical research with respect to the treatment of diseases such as cancer, diabetes, or obesit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5476ec9996d80c5b4b38d82a547248e4
https://doi.org/10.1093/toxsci/kfab139
https://doi.org/10.1093/toxsci/kfab139
Autor:
Maria G. Winter, Thorben Schramm, Sylwia Kierszniowska, Andrea Ebert-Jung, Sebastian E. Winter, Gottfried Unden, Hannes Link, Christopher Schubert, Kerstin Nagel-Wolfrum
Publikováno v:
Environmental Microbiology. 23:2564-2577
C4-dicarboxylates, such as fumarate, L-malate and L-aspartate represent substrates for anaerobic growth of Escherichia coli by fumarate respiration. Here, we determined whether C4-dicarboxylate metabolism as well as fumarate respiration contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636b628d3dc512257b9ee65b7e46134b
https://doi.org/10.1111/1462-2920.15478
https://doi.org/10.1111/1462-2920.15478
Autor:
Andrea Ebert, Kai-Uwe Goss
Publikováno v:
Chemical Research in Toxicology. 33:1835-1844
We present a purely mechanistic model to predict protonophoric uncoupling activity ECw of organic acids. All required input information can be derived from their chemical structure. This makes it a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508f314b8a31895bfee2e3f31d0049ed
https://doi.org/10.1021/acs.chemrestox.0c00063
https://doi.org/10.1021/acs.chemrestox.0c00063
Publikováno v:
Environmental Science & Technology. 54:5051-5061
The search for alternatives to bioaccumulative perfluoroalkyl acids (PFAAs) is ongoing. New, still highly fluorinated alternatives are produced in hopes of reducing bioaccumulation. To better estimate this bioaccumulative behavior, we performed dialy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea4edfbfddd0ad9cfbe10b929c99626
https://doi.org/10.1021/acs.est.0c00175
https://doi.org/10.1021/acs.est.0c00175
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1864:183953
Transwell experiments with Caco-2 or MDCK cells are the gold standard for determining the intestinal permeability of chemicals. The intrinsic membrane permeability (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cacde3931e653bca70a80bdfe479070
https://doi.org/10.1016/j.bbamem.2022.183953
https://doi.org/10.1016/j.bbamem.2022.183953