Výsledky vyhledávání - "Andrea E. Hafeman"

BAX326 (recombinant coagulation factor IX) for the treatment and prophylaxis of hemophilia B

Autor: Andrea E. Hafeman, Jerzy Windyga, Brigitt E. Abbuehl

Publikováno v: Expert Review of Hematology. 7:333-342

Individuals with hemophilia B experience frequent and spontaneous bleeding episodes into joints and muscles that can lead to severe arthropathy, chronic pain, disability, and diminished quality of life (QoL). Prophylaxis with factor nine (FIX) concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93aff8dffe3037b80d01d66322ac8049
https://doi.org/10.1586/17474086.2014.903153

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Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora

Autor: Gloria Gutierrez, Atsushi Okawa, Scott A. Guelcher, Javier Esparza, Toshitaka Yoshii, Andrea E. Hafeman

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 8:589-595

Statins, a class of naturally-occurring compounds that inhibit HMG-CoA reductase, are known to increase endogenous bone morphogenetic protein-2 (BMP-2) expression. Local administration of statins has been shown to stimulate fracture repair in in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dabf6b794a181d6b659757ac33216e8f
https://doi.org/10.1002/term.1547

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Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds

Autor: Scott A. Guelcher, Andrea E. Hafeman, Katarz Yna J. Zienkiewicz, Hak-Joon Sung, Lillian B. Nanney, Angela L. Zachman, Jeffrey M. Davidson

Publikováno v: Biomaterials. 32:419-429

Characterization of the degradation mechanism of polymeric scaffolds and delivery systems for regenerative medicine is essential to assess their clinical applicability. Key performance criteria include induction of a minimal, transient inflammatory r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3371a8e2dc98228900d34a339c189e6b
https://doi.org/10.1016/j.biomaterials.2010.08.108

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Local Delivery of Tobramycin from Injectable Biodegradable Polyurethane Scaffolds

Autor: Scott A. Guelcher, Joseph C. Wenke, Brandon Litzner, Andrea E. Hafeman, Erin Carney, Charles W. Stratton, Katarzyna J. Zienkiewicz

Publikováno v: Journal of Biomaterials Science, Polymer Edition. 21:95-112

Infections often compromise the healing of open fractures. While local antibiotic delivery from PMMA beads is an established clinical treatment of infected fractures, surgical removal of the beads is required before implanting a bone graft. A more id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba0ac08306ea240372e4bc33e5a1170
https://doi.org/10.1163/156856209x410256

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The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora

Autor: Scott A. Guelcher, Toshitaka Yoshii, Jeffrey S. Nyman, Andrea E. Hafeman, Bing Li, Joseph C. Wenke

Publikováno v: Biomaterials. 30:6768-6779

Scaffolds prepared from biodegradable polyurethanes (PUR) have been investigated as a supportive matrix and delivery system for skin, cardiovascular, and bone tissue engineering. While previous studies have suggested that PUR scaffolds are biocompati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e31359c75a9a76f32f48512af95d499
https://doi.org/10.1016/j.biomaterials.2009.08.038

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Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

Autor: Jeffrey M. Davidson, Bing Li, Toshitaka Yoshii, Andrea E. Hafeman, Katarzyna J. Zienkiewicz, Scott A. Guelcher

Publikováno v: Pharmaceutical Research. 25:2387-2399

The purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering.Scaffolds were synthesized using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d36076b7d3280583bc82a798ac6971
https://doi.org/10.1007/s11095-008-9618-z

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Solid-State Stabilization of α-Chymotrypsin and Catalase with Carbohydrates

Autor: Brian A. Pethica, Pablo G. Debenedetti, Sau Lawrence Lee, Andrea E. Hafeman, David J. Moore

Publikováno v: Industrial & Engineering Chemistry Research. 45:5134-5147

We report a systematic investigation of the effects of five carbohydrates (fructose, sucrose, trehalose, maltotriose, and dextran), freeze-drying, and subsequent heat treatment (up to 8 days at 80 °C) on the structure and enzymatic activity of α-ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fc257e7bd1ed531113e3cb5bfbc9759
https://doi.org/10.1021/ie0513503

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BAX326 (RIXUBIS): a novel recombinant factor IX for the control and prevention of bleeding episodes in adults and children with hemophilia B

Autor: Jerzy Windyga, Maria Helena Solano Trujillo, Andrea E. Hafeman

Publikováno v: Repositorio Digital Institucional ReDi
Fundación Universitaria de Ciencias de la Salud-FUCS
instacron:Fundación Universitaria de Ciencias de la Salud-FUCS

Hemophilia B management has improved considerably since the introduction of high-purity plasma-derived factor IX (pdFIX) products in the early 1990s. Recombinant FIX (rFIX) was introduced more recently and has potential safety advantages over the old

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f085432b359099606e13f6c401c079
https://pubmed.ncbi.nlm.nih.gov/25324957

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