Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrea E. Doak"'
Autor:
Andrea E. Doak, Kevin J. Cheung
Publikováno v:
Cancer Research. 83:P6-14
An early step in breast cancer progression is invasion of tumor cells into surrounding tissues. In many breast cancers, particularly ductal carcinomas, this invasion is accomplished by tumor cells migrating as a cohesive group. This often involves ce
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 18:231-256
Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells while maintaining contacts with one another. Collective metastasis enabl
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Representation of tarloxotinib conversion to its irreversible EGFR/HER2 inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fb642c5c8e27d132f13b95faa65d12
https://doi.org/10.1158/1078-0432.22478582.v1
https://doi.org/10.1158/1078-0432.22478582.v1
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Supplemental table 2. Tarloxotinib-E inhibition of the ErbB family using biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801ef129db5c6e8a2e344c4aa005933a
https://doi.org/10.1158/1078-0432.22478555.v1
https://doi.org/10.1158/1078-0432.22478555.v1
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Cell lines used in the paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074d8cdf8db9af8b47df7b7efc1c9dfc
https://doi.org/10.1158/1078-0432.22478558
https://doi.org/10.1158/1078-0432.22478558
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Purpose:Approved therapies for EGFR exon 20, ERBB2 mutations, and NRG1 fusions are currently lacking for non–small cell lung cancer and other cancers. Tarloxotinib is a prodrug that harnesses tumor hypoxia to generate high levels of a potent, coval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4145bef00d56c6f51b6718a98baed3fb
https://doi.org/10.1158/1078-0432.c.6529985
https://doi.org/10.1158/1078-0432.c.6529985
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Tarloxotinib (prodrug) is less effective against WT and mutant forms of EGFR and HER2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bfc56790c836178a7e8fc84b60279f
https://doi.org/10.1158/1078-0432.22478573
https://doi.org/10.1158/1078-0432.22478573
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Body weight changes in tumor xenograft and PDX-bearing nude mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2509c402bfec93471d16bad11ca9eb88
https://doi.org/10.1158/1078-0432.22478561
https://doi.org/10.1158/1078-0432.22478561
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Tarloxotinib-E inhibits ErbB family members phosphorylation and downstream signaling in EGFR, HER2 and NRG1 driven cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abda475d63be69607e11cc9c380144c
https://doi.org/10.1158/1078-0432.22478576
https://doi.org/10.1158/1078-0432.22478576
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Estimation of human equivalent dose of afatinib in nude mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a0b48a6526e1b3eab934a4855f598e
https://doi.org/10.1158/1078-0432.22478567.v1
https://doi.org/10.1158/1078-0432.22478567.v1