Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Andrea E, Prota"'
Autor:
Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307153 (2024)
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of microtubule-ta
Externí odkaz:
https://doaj.org/article/6fdecf164cea42cdbd9b349cb2345daf
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Helena Pérez-Peña, Anne-Catherine Abel, Maxim Shevelev, Andrea E. Prota, Stefano Pieraccini, Dragos Horvath
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 285 (2023)
Microtubules are highly dynamic polymers of α,β-tubulin dimers which play an essential role in numerous cellular processes such as cell proliferation and intracellular transport, making them an attractive target for cancer and neurodegeneration res
Externí odkaz:
https://doaj.org/article/d4f593ddf054481a8b5d47b16c72ba32
Autor:
Xiansha Xiao, Joost Willemse, Patrick Voskamp, Xinmeng Li, Andrea E. Prota, Meindert Lamers, Navraj Pannu, Jan Pieter Abrahams, Gilles P. van Wezel
Publikováno v:
Open Biology, Vol 11, Iss 2 (2021)
In most bacteria, cell division begins with the polymerization of the GTPase FtsZ at mid-cell, which recruits the division machinery to initiate cell constriction. In the filamentous bacterium Streptomyces, cell division is positively controlled by S
Externí odkaz:
https://doaj.org/article/500f1311253148e884490861868b1058
Autor:
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
Externí odkaz:
https://doaj.org/article/25fe86c26b2f41b2afb5b7ee20b13b6c
Autor:
Juan Estévez-Gallego, Fernando Josa-Prado, Siou Ku, Ruben M Buey, Francisco A Balaguer, Andrea E Prota, Daniel Lucena-Agell, Christina Kamma-Lorger, Toshiki Yagi, Hiroyuki Iwamoto, Laurence Duchesne, Isabel Barasoain, Michel O Steinmetz, Denis Chrétien, Shinji Kamimura, J Fernando Díaz, Maria A Oliva
Publikováno v:
eLife, Vol 9 (2020)
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural changes in the lattice, which
Externí odkaz:
https://doaj.org/article/eb49d1e2fe6445b783e2a3c85b0c7bbb
Autor:
Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly d
Externí odkaz:
https://doaj.org/article/cd703e3a1db842d9bf536015c27b64dc
Autor:
Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi
Externí odkaz:
https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf
Autor:
Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S. Doré, Tian Geng, Robert M. Cooke, Mengning Liang, Andrea E. Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O. Steinmetz, Meitian Wang, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Serial crystallography was developed for protein crystal data collection with X-ray free-electron lasers. Here the authors present several examples which show that serial crystallography using high-viscosity injectors can also be routinely employed f
Externí odkaz:
https://doaj.org/article/03611f85d66b40d78ee218591843f7af
Autor:
Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Buparlisib/BKM120 is in phase 3 clinical trials as a phosphoinositide 3-kinase (PI3K) inhibitor. Here, Bohnackeret al. combine chemical biology and structural biology approaches to segregate BKM120’s biological actions, and suggest that it causes m
Externí odkaz:
https://doaj.org/article/a5212909a4a7490db4d79600c172c822