Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

Autor: Raúl González-Domínguez, Pol Castellano-Escuder, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Hyunah Lee, Catherine Helmer, Mercè Pallàs, Mireia Urpi-Sarda, Alex Sánchez-Pla, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Claudine Manach, Sandrine Thuret, Cécilia Samieri, Cristina Andres-Lacueva

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Background Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia

Externí odkaz: https://doaj.org/article/fe54f7084a00400d884b9af9f92d4333

Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Autor: Sophie Lefèvre-Arbogast, Boris P Hejblum, Catherine Helmer, Christian Klose, Claudine Manach, Dorrain Y Low, Mireia Urpi-Sarda, Cristina Andres-Lacueva, Raúl González-Domínguez, Ludwig Aigner, Barbara Altendorfer, Paul J Lucassen, Silvie R Ruigrok, Chiara De Lucia, Andrea Du Preez, Cécile Proust-Lima, Sandrine Thuret, Aniko Korosi, Cécilia Samieri

Publikováno v: EBioMedicine, Vol 64, Iss , Pp 103216- (2021)

Background: Brain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to cognitive decline remains unclear at the system level. Methods: We studied participants from the Three-City study, a multicentr

Externí odkaz: https://doaj.org/article/4ee2264573804790a371533b89baef44

Increased maternal inflammation and poorer infant neurobehavioural competencies in women with a history of major depressive disorder from the psychiatry research and motherhood – Depression (PRAM-D) study

Autor: S Osborne, Susan Pawlby, Alessandra Biaggi, Andrea Du Preez, Katie Hazelgrove, Susan Conroy, Vaheshta Sethna, Patricia A. Zunszain, Carmine M. Pariante, Naghmeh Nikkheslat

Publikováno v: Osborne, S, Biaggi, A, Hazelgrove, K, Preez, A D, Nikkheslat, N, Sethna, V, Zunszain, P A, Conroy, S, Pawlby, S & Pariante, C M 2022, ' Increased maternal inflammation and poorer infant neurobehavioural competencies in women with a history of major depressive disorder from the psychiatry research and motherhood – Depression (PRAM-D) study ', Brain, Behavior, and Immunity, vol. 99, pp. 223-230 . https://doi.org/10.1016/j.bbi.2021.09.020

Introduction Stress in pregnancy is associated with adverse outcomes in offspring, and developmental programming is a potential mechanism. We have previously shown that depression in pregnancy is a valid and clearly defined stress paradigm, and both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b56780c00b8a0f2275f2f2d088c01ea
https://doi.org/10.1016/j.bbi.2021.09.020

The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia

Autor: Claudine Manach, Cristina Andres-Lacueva, Cécile Proust-Lima, Cécile Delcourt, Vikki Houghton, Barbara Altendorfer, Cécilia Samieri, Alex Sánchez-Pla, Ludwig Aigner, Chiara De Lucia, Sandrine Thuret, Aniko Korosi, Paul J. Lucassen, Dorrain Y Low, Mireia Urpi-Sarda, Andrea Du Preez, Sophie Lefèvre-Arbogast, Raúl González-Domínguez, Catherine Féart, Mercè Pallàs, Catherine Helmer, Silvie R. Ruigrok

Publikováno v: Alzheimer's & Dementia, 18(4), 654-675. Elsevier
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, ⟨10.1002/alz.12428⟩
Alzheimer's and Dementia
Alzheimer's and Dementia, Elsevier, 2021, ⟨10.1002/alz.12428⟩

International audience; Introduction: Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7895470274a607a4c803e65f8e8b67
https://dare.uva.nl/personal/pure/en/publications/the-serum-metabolome-mediates-the-concert-of-diet-exercise-and-neurogenesis-determining-the-risk-for-cognitive-decline-and-dementia(7df8a80a-ddbd-491d-bf4f-8aed733948c7).html

Mother–infant interaction in women with depression in pregnancy and in women with a history of depression: the Psychiatry Research and Motherhood – Depression (PRAM-D) study

Autor: Paola Dazzan, Freddie Waites, Carmine M. Pariante, Rebecca Bind, Katie Hazelgrove, Susan Conroy, Alessandra Biaggi, Vaheshta Sethna, Aoife Bairead, Andrea Du Preez, S Osborne, Susan Pawlby

Publikováno v: BJPsych Open

Background Little is known about the effects of depression before birth on the quality of the mother–infant interaction. Aims To understand whether depression, either in pregnancy or in lifetime before pregnancy, disrupts postnatal mother–infant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63895e90b4786c256e922271a9403f13
https://doi.org/10.1192/bjo.2021.52