Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

Autor: Raúl González-Domínguez, Pol Castellano-Escuder, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Hyunah Lee, Catherine Helmer, Mercè Pallàs, Mireia Urpi-Sarda, Alex Sánchez-Pla, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Claudine Manach, Sandrine Thuret, Cécilia Samieri, Cristina Andres-Lacueva

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Background Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia

Externí odkaz: https://doaj.org/article/fe54f7084a00400d884b9af9f92d4333

Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Autor: Sophie Lefèvre-Arbogast, Boris P Hejblum, Catherine Helmer, Christian Klose, Claudine Manach, Dorrain Y Low, Mireia Urpi-Sarda, Cristina Andres-Lacueva, Raúl González-Domínguez, Ludwig Aigner, Barbara Altendorfer, Paul J Lucassen, Silvie R Ruigrok, Chiara De Lucia, Andrea Du Preez, Cécile Proust-Lima, Sandrine Thuret, Aniko Korosi, Cécilia Samieri

Publikováno v: EBioMedicine, Vol 64, Iss , Pp 103216- (2021)

Background: Brain lipid metabolism appears critical for cognitive aging, but whether alterations in the lipidome relate to cognitive decline remains unclear at the system level. Methods: We studied participants from the Three-City study, a multicentr

Externí odkaz: https://doaj.org/article/4ee2264573804790a371533b89baef44

Increased maternal inflammation and poorer infant neurobehavioural competencies in women with a history of major depressive disorder from the psychiatry research and motherhood – Depression (PRAM-D) study

Autor: S Osborne, Susan Pawlby, Alessandra Biaggi, Andrea Du Preez, Katie Hazelgrove, Susan Conroy, Vaheshta Sethna, Patricia A. Zunszain, Carmine M. Pariante, Naghmeh Nikkheslat

Publikováno v: Osborne, S, Biaggi, A, Hazelgrove, K, Preez, A D, Nikkheslat, N, Sethna, V, Zunszain, P A, Conroy, S, Pawlby, S & Pariante, C M 2022, ' Increased maternal inflammation and poorer infant neurobehavioural competencies in women with a history of major depressive disorder from the psychiatry research and motherhood – Depression (PRAM-D) study ', Brain, Behavior, and Immunity, vol. 99, pp. 223-230 . https://doi.org/10.1016/j.bbi.2021.09.020

Introduction Stress in pregnancy is associated with adverse outcomes in offspring, and developmental programming is a potential mechanism. We have previously shown that depression in pregnancy is a valid and clearly defined stress paradigm, and both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b56780c00b8a0f2275f2f2d088c01ea
https://doi.org/10.1016/j.bbi.2021.09.020

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice

Autor: Sandrine Thuret, Andrea Du Preez, Inez Eiben, Ksenia Musaelyan, Patricia A. Zunszain, Diletta Onorato, Martin Egeland, Carmine M. Pariante, Cathy Fernandes

Publikováno v: Brain, Behavior, and Immunity. 91:24-47

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and translatable models for studying the neurobiological basis of major depression. Although the model currently has multiple advantages, it does not entirely follow th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5651fc22a929fab54545fcde21d5a968
https://doi.org/10.1016/j.bbi.2020.07.015

Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study

Autor: Andrea Du Preez, Sophie Lefèvre-Arbogast, Raúl González-Domínguez, Vikki Houghton, Chiara de Lucia, Dorrain Y. Low, Catherine Helmer, Catherine Féart, Cécile Delcourt, Cécile Proust-Lima, Mercè Pallàs, Alex Sánchez-Pla, Mireia Urpi-Sardà, Silvie R. Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Claudine Manach, Cristina Andres-Lacueva, Cécilia Samieri, Sandrine Thuret

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, In press, ⟨10.1038/s41380-022-01644-1⟩
Molecular Psychiatry, 27(8). Nature Publishing Group

Environmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with the brain via the circulatory system and interacts with hippocampal neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9113ed4c8119d5a10d02f05644663b7e
https://pubmed.ncbi.nlm.nih.gov/35794184