Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrea Desmond"'
Autor:
Ravindra Mylavagnanam, Sridhar Ramaswamy, Elena Zarcaro, Srinivas Vinod Saladi, Andrea Desmond, Murat Yildirim, Varunika Vivekanandan, Michael S. Lawrence, Kenneth N. Ross, Mihriban Karaayvaz-Yildirim, Rebecca E. Silberman, Adam Langenbucher, Leif W. Ellisen, Angelika Amon, Michelle C. Specht, Hiranmayi Ravichandran
Publikováno v:
Science Advances. 6
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly understood. To reveal early steps in BRCA2-associated carcinogenesis, we analyzed sorted cell
Autor:
Michelle C. Specht, Murat Yildirim, Michael S. Lawrence, Mihriban Karaayvaz, Srinivas Vinod Saladi, Angelika Amon, Adam Langenbucher, Rebecca E. Silberman, Varunika Vivekanandan, Andrea Desmond, Leif W. Ellisen, Sridhar Ramaswamy, Kenneth N. Ross, Ravindra Mylavagnanam, Elena Zarcaro, Hiranmayi Ravichandran
Women harboring heterozygous germline mutations of BRCA2 have a 50-80% risk of developing breast cancer, yet the early pathogenesis of these cancers is poorly understood. We sought to reveal early steps in BRCA2-associated carcinogenesis through anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aca1536bb1e9698d683f92a1ea1e17
https://doi.org/10.1101/729301
https://doi.org/10.1101/729301
Autor:
Mihriban, Karaayvaz-Yildirim, Rebecca E, Silberman, Adam, Langenbucher, Srinivas Vinod, Saladi, Kenneth N, Ross, Elena, Zarcaro, Andrea, Desmond, Murat, Yildirim, Varunika, Vivekanandan, Hiranmayi, Ravichandran, Ravindra, Mylavagnanam, Michelle C, Specht, Sridhar, Ramaswamy, Michael, Lawrence, Angelika, Amon, Leif W, Ellisen
Publikováno v:
Science Advances
Normal breast epithelia from BRCA2 mutation carriers display DNA damage and attenuated checkpoint responses.
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of thes
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of thes
Autor:
Allison W. Kurian, Yuya Kobayashi, Federico A. Monzon, Michael J. Anderson, Andrea Desmond, Leif W. Ellisen, Geoffrey B. Nilsen, Stephen E Lincoln, Kevin B. Jacobs, Shan Yang, Meredith A. Mills, James M. Ford
Publikováno v:
The Journal of Molecular Diagnostics. 17:533-544
Gene panels for hereditary breast and ovarian cancer risk assessment are gaining acceptance, even though the clinical utility of these panels is not yet fully defined. Technical questions remain, however, about the performance and clinical interpreta
Abstract P4-12-04: Clinical evaluation of multigene testing for hereditary breast and ovarian cancer
Autor:
Meredith A. Mills, Michelle Gabree, Leif W. Ellisen, Kristen M. Shannon, James M. Ford, Federico A. Monzon, Allison W. Kurian, Andrea Desmond, Michael Anderson, Yuya Kobayashi, Stephen E Lincoln
Publikováno v:
Cancer Research. 75:P4-12
Background: Advances in DNA sequencing technology have fueled the development of multigene panels for hereditary cancer testing. While such assays are potentially both practical and affordable for routine clinical genetic testing, there remains uncer
Autor:
Stephen Lincoln, Allison Kurian, Andrea Desmond, Geoffrey Nilsen, Kevin Jacobs, Shan Yang, Reece Hart, Federico Monzon, Leif Ellisen, James Ford
Publikováno v:
Cancer Research. 75:P4-12
Introduction: Next Generation Sequencing, or NGS technology is gaining acceptance in diagnostic laboratories for multigene panel testing. However questions remain about the sensitivity, specificity and clinical implications of this new technology and
Autor:
Meredith A. Mills, Michele Gabree, Kristen M. Shannon, Andrea Desmond, Nora Horick, Michael J. Anderson, Nadine Tung, James M. Ford, Allison W. Kurian, Shan Yang, Leif W. Ellisen, Yuya Kobayashi, Stephen E Lincoln
Publikováno v:
JAMA oncology. 1(7)
Importance The practice of genetic testing for hereditary breast and/or ovarian cancer (HBOC) is rapidly evolving owing to the recent introduction of multigene panels. While these tests may identify 40% to 50% more individuals with hereditary cancer
Autor:
James M. Ford, Meredith A. Mills, Federico A. Monzon, Stephen E Lincoln, Yuya Kobayashi, Leif W. Ellisen, Andrea Desmond, Allison W. Kurian, Shan Yang
Publikováno v:
Journal of Medical Genetics. 52:A6.1-A6
Background The practice of genetic testing is rapidly evolving with the recent introduction of multi-gene panels. While the prevalence of non-BRCA1/2 mutations in HBOC patients is now well documented, the clinical impact of these findings is not yet
Clinical impact of multi-gene panel testing for hereditary breast and ovarian cancer risk assessment
Autor:
Nadine Tung, Michele Gabree, Andrea Desmond, Allison W. Kurian, James M. Ford, Meredith A. Mills, Stephen E Lincoln, Leif W. Ellisen, Kristen M. Shannon
Publikováno v:
Journal of Clinical Oncology. 33:1513-1513
1513 Background: Genetic testing for hereditary breast and ovarian cancer is evolving with the recent introduction of multi-gene panels, although the clinical impact of such panels is as yet poorly...