Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Andrea Danani"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0010545 (2023)
Chagas' disease is a neglected tropical disease caused by the kinetoplastid protozoan Trypanosoma cruzi. The only therapies are the nitroheterocyclic chemicals nifurtimox and benznidazole that cause various adverse effects. The need to create safe an
Externí odkaz:
https://doaj.org/article/0abe6a01cc204a61baced8f759d0fab2
Publikováno v:
ACS Omega, Vol 5, Iss 6, Pp 2978-2986 (2020)
Externí odkaz:
https://doaj.org/article/a066446ea80a47a9924b4e081f6d25f8
Autor:
Evgeniya Trofimenko, Gianvito Grasso, Mathieu Heulot, Nadja Chevalier, Marco A Deriu, Gilles Dubuis, Yoan Arribat, Marc Serulla, Sebastien Michel, Gil Vantomme, Florine Ory, Linh Chi Dam, Julien Puyal, Francesca Amati, Anita Lüthi, Andrea Danani, Christian Widmann
Publikováno v:
eLife, Vol 10 (2021)
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channel
Externí odkaz:
https://doaj.org/article/98b234728cca409a8a4e7ab3072baed6
Autor:
Franck Marquet, Filip Stojceski, Gianvito Grasso, Viorica Patrulea, Andrea Danani, Gerrit Borchard
Publikováno v:
Polymers, Vol 14, Iss 20, p 4409 (2022)
The simulation of large molecular systems remains a daunting challenge, which justifies the exploration of novel methodologies to keep computers as an ideal companion tool for everyday laboratory work. Whole micelles, bigger than 20 nm in size, forme
Externí odkaz:
https://doaj.org/article/741977ce54a845289263fd7719e5f593
Autor:
Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A. Deriu, Andrea Danani, Sandrine Bourdoulous, Francesca Re
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-7 (2019)
Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubic
Externí odkaz:
https://doaj.org/article/921623da95d24c5087a2b97d5ba2f340
Autor:
Gianvito Grasso, Andrea Danani
Publikováno v:
Advances in Physics: X, Vol 5, Iss 1 (2020)
Several neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain areas. In case of Alzheimer Disease, the accumulation of the Amyloi
Externí odkaz:
https://doaj.org/article/38fcfa77787f4257a066b1d0780a52f8
Autor:
Roberta Dal Magro, Sara Simonelli, Alysia Cox, Beatrice Formicola, Roberta Corti, Valeria Cassina, Luca Nardo, Francesco Mantegazza, Domenico Salerno, Gianvito Grasso, Marco Agostino Deriu, Andrea Danani, Laura Calabresi, Francesca Re
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Much evidence suggests a protective role of high-density lipoprotein (HDL) and its major apolipoprotein apoA-I, in Alzheimer’s disease (AD). The biogenesis of nascent HDL derived from a first lipidation of apoA-I, which is synthesized by the liver
Externí odkaz:
https://doaj.org/article/169eedbe7a254a25a58614386321f8bb
Autor:
Gianvito Grasso, Martina Rebella, Umberto Morbiducci, Jack A. Tuszynski, Andrea Danani, Marco A. Deriu
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Alzheimer's Disease (AD) is related with the abnormal aggregation of amyloid β-peptides Aβ1−40 and Aβ1−42, the latter having a polymorphic character which gives rise to U- or S-shaped fibrils. Elucidating the role played by the nanoscale-mater
Externí odkaz:
https://doaj.org/article/63f7907eb76f4ed08e48656e66f9fd4c
Autor:
Stefano Muscat, Lorenzo Pallante, Filip Stojceski, Andrea Danani, Gianvito Grasso, Marco Agostino Deriu
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2017 (2020)
The pursuit for effective strategies inhibiting the amyloidogenic process in neurodegenerative disorders, such as Alzheimer’s disease (AD), remains one of the main unsolved issues, and only a few drugs have demonstrated to delay the degeneration of
Externí odkaz:
https://doaj.org/article/88587c071cd941169d16b8a65a5cc25e
Autor:
Francesco Gentile, Marco A. Deriu, Ginevra Licandro, Alessio Prunotto, Andrea Danani, Jack A. Tuszynski
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 8316-8340 (2015)
Toll-Like Receptors (TLR) are a large family of proteins involved in the immune system response. Both the activation and the inhibition of these receptors can have positive effects on several diseases, including viral pathologies and cancer, therefor
Externí odkaz:
https://doaj.org/article/0809d6115fe146a58ec21128248dec82