Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andrea D. van Dam"'
Autor:
Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, Katherine A. Kentistou, Peter K. Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Karpe, Katherine E. Pinnick
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111136- (2022)
Summary: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for ad
Externí odkaz:
https://doaj.org/article/d702a76facc64b9ca3d2316c0276c1b2
Autor:
Laura G.M. Janssen, Andrea D. van Dam, Mark J.W. Hanssen, Sander Kooijman, Kimberly J. Nahon, Hanneke Reinders, Ingrid M. Jazet, Wouter D. van Marken Lichtenbelt, Patrick C.N. Rensen, Natasha M. Appelman-Dijkstra, Mariëtte R. Boon
Publikováno v:
Diabetes & Metabolism Journal, Vol 44, Iss 2, Pp 326-335 (2020)
BackgroundSouth Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance. The Wnt protein family interacts with insulin signaling, and impaired Wnt signaling is associa
Externí odkaz:
https://doaj.org/article/e185adc9d6304da6bc3ca6cd353befeb
Autor:
Eline N. Kuipers, Andrea D. van Dam, Dov B. Ballak, Ellemiek A. de Wit, Charles A. Dinarello, Rinke Stienstra, Janna A. van Diepen, Patrick C.N. Rensen, Mariëtte R. Boon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2264 (2018)
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them from diet-induced obesity and associated metabolic complications including dyslipidemia, infla
Externí odkaz:
https://doaj.org/article/4dbb2c7596974308ac867267ee07ce91
Autor:
Eline N. Kuipers, Andrea D. van Dam, Ntsiki M. Held, Isabel M. Mol, Riekelt H. Houtkooper, Patrick C.N. Rensen, Mariëtte R. Boon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1786 (2018)
Obesity and dyslipidemia are major risk factors for the development of cardiovascular diseases (CVD). Quercetin, a natural flavonoid, lowers plasma triglycerides (TG) in human intervention studies, and its intake is associated with lower CVD risk. Th
Externí odkaz:
https://doaj.org/article/1e960c3f6f0e425192bc720c089e8f51
Autor:
Natasha M. Appelman-Dijkstra, Kimberly J. Nahon, Mark J. W. Hanssen, Mariëtte R. Boon, Ingrid M. Jazet, Laura G.M. Janssen, Patrick C.N. Rensen, Hanneke Reinders, Wouter D. van Marken Lichtenbelt, Sander Kooijman, Andrea D. van Dam
Publikováno v:
Diabetes & Metabolism Journal, Vol 44, Iss 2, Pp 326-335 (2020)
Diabetes & Metabolism Journal
Diabetes and Metabolism Journal, 44(2), 326-335. KOREAN DIABETES ASSOC
Diabetes and Metabolism Journal, 44(2):e54, 326-335. Korean Diabetes Association
Diabetes & Metabolism Journal
Diabetes and Metabolism Journal, 44(2), 326-335. KOREAN DIABETES ASSOC
Diabetes and Metabolism Journal, 44(2):e54, 326-335. Korean Diabetes Association
BACKGROUND: South Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance. The Wnt protein family interacts with insulin signaling, and impaired Wnt signaling is assoc
Autor:
Manu Verma, Nellie Y. Loh, Rugivan Sabaratnam, Senthil K. Vasan, Andrea D. van Dam, Marijana Todorčević, Matthew J. Neville, Enrique Toledo, Fredrik Karpe, Constantinos Christodoulides
Publikováno v:
Metabolism. 133:155240
Introduction Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo stu
Autor:
Constantinos Christodoulides, Hetty C M Sips, Andrea D. van Dam, Sander Kooijman, Mariëtte R. Boon, Eline N. Kuipers, Jia Liu, Fredrik Karpe, Patrick C.N. Rensen, Guangqian Zhou, Jennifa C. Dorleijn, Antoine A.F. de Vries
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. Elsevier
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1864(12). ELSEVIER
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1864(12). ELSEVIER
Brown adipose tissue (BAT) is a potential target to treat cardiometabolic disorders because of its capacity to combust glucose and fatty acids for thermoregulation. Its cellular and molecular investigation in humans is hampered by the limited availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69aca2a190beab7dc6a04faa280604b6
https://doi.org/10.1016/j.bbalip.2019.08.007
https://doi.org/10.1016/j.bbalip.2019.08.007
Autor:
Tom H. M. Ottenhoff, Mark J. W. Hanssen, Patrick C.N. Rensen, Hetty C M Sips, Andrea D. van Dam, Mariëlle C. Haks, Cindy J. M. Hülsman, Ingrid M. Jazet, Wouter D. van Marken Lichtenbelt, Robin van Eenige, Edwin Quinten, Mariëtte R. Boon
Publikováno v:
Diabetologia, 60(12), 2525-2528
Diabetologia, 60(12), 2525-2528. Springer, Cham
Diabetologia, 60(12), 2525-2528. Springer, Cham
Autor:
Vanessa van Harmelen, J. Sjef Verbeek, Sander Kooijman, Patrick C.N. Rensen, Ko Willems van Dijk, Saeed Katiraei, Frits Koning, Irene O.C.M. Vroegrijk, Lianne van Beek, Mattijs M. Heemskerk, Andrea D. van Dam
Publikováno v:
Obesity. 23:2435-2444
Objective Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the mechanisms by which these antibodies affect IR are largely unknown. This study investigated
Autor:
Andrea D. van Dam, Joanne Verheij, Louis M. Havekes, José W.A. van der Hoorn, Lars Verschuren, Wen Liang, Petra Mulder, Robert Kleemann, Anita M. van den Hoek, Hans M.G. Princen, Mariëtte R. Boon
Publikováno v:
British Journal of Pharmacology. 172:5293-5305
BACKGROUND AND PURPOSE: Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and management of a wide rang